Details for: RBMS3 AS3

Gene ID: 100873979

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: RBMS3 AS3

Ensembl ID: ENSG00000235904

Description: RBMS3 antisense RNA 3

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • fibroblast of lung CL0002553
    CSI 13.66
    rCSI 12.71%
    PRS 92.9
  • inhibitory interneuron CL0000498
    CSI 11.08
    rCSI 25.58%
    PRS 83.23
  • adipocyte CL0000136
    CSI 6.69
    rCSI 8.59%
    PRS 84.22
  • smooth muscle cell CL0000192
    CSI 6.66
    rCSI 15.88%
    PRS 86.03
  • hepatic stellate cell CL0000632
    CSI 6.21
    rCSI 23.27%
    PRS 87.65
  • epicardial adipocyte CL1000309
    CSI 5.99
    rCSI 19.51%
    PRS 89.12
  • cardiac muscle cell CL0000746
    CSI 5.87
    rCSI 8.42%
    PRS 84.19
  • alveolar adventitial fibroblast CL4028006
    CSI 5.83
    rCSI 9.2%
    PRS 92.49
  • Kupffer cell CL0000091
    CSI 5.33
    rCSI 12.2%
    PRS 92.5
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 5.33
    rCSI 6.63%
    PRS 77.45
  • subcutaneous adipocyte CL0002521
    CSI 4.91
    rCSI 25.14%
    PRS 93.39
  • blood vessel endothelial cell CL0000071
    CSI 4.72
    rCSI 9.8%
    PRS 90.02
  • endocardial cell CL0002350
    CSI 4.55
    rCSI 21.78%
    PRS 88.41
  • pericyte CL0000669
    CSI 4.16
    rCSI 11.08%
    PRS 69.7
  • alveolar type 1 fibroblast cell CL4028004
    CSI 4.13
    rCSI 4.52%
    PRS 93.08
  • respiratory basal cell CL0002633
    CSI 3.66
    rCSI 3.79%
    PRS 93
  • bronchus fibroblast of lung CL2000093
    CSI 3.56
    rCSI 2.9%
    PRS 90.98
  • regular atrial cardiac myocyte CL0002129
    CSI 3.49
    rCSI 11.23%
    PRS 88.21
  • melanocyte CL0000148
    CSI 3.45
    rCSI 2.55%
    PRS 88.33
  • cardiac neuron CL0010022
    CSI 3.34
    rCSI 10.7%
    PRS 90.44
  • contractile cell CL0000183
    CSI 3.33
    rCSI 9.83%
    PRS 91
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 3.31
    rCSI 5.56%
    PRS 79.65
  • basal cell CL0000646
    CSI 3.16
    rCSI 4.23%
    PRS 89.13
  • Schwann cell CL0002573
    CSI 2.93
    rCSI 8.32%
    PRS 88.36
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.76
    rCSI 3.55%
    PRS 80.76
  • mural cell CL0008034
    CSI 2.66
    rCSI 9.03%
    PRS 88.12
  • mesothelial cell CL0000077
    CSI 2.63
    rCSI 10.3%
    PRS 76.33
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.42
    rCSI 4.39%
    PRS 85.64
  • vascular leptomeningeal cell CL4023051
    CSI 2.41
    rCSI 4.23%
    PRS 88.35
  • cardiac endothelial cell CL0010008
    CSI 2.05
    rCSI 8.28%
    PRS 92.19
  • airway submucosal gland duct basal cell CL4033024
    CSI 2.04
    rCSI 13.06%
    PRS 92.8
  • chondrocyte CL0000138
    CSI 1.96
    rCSI 3.12%
    PRS 87.37
  • lung pericyte CL0009089
    CSI 1.79
    rCSI 4.72%
    PRS 94.86
  • pulmonary artery endothelial cell CL1001568
    CSI 1.72
    rCSI 2.34%
    PRS 95.36
  • fibroblast of cardiac tissue CL0002548
    CSI 1.68
    rCSI 8.03%
    PRS 92.46
  • tracheobronchial smooth muscle cell CL0019019
    CSI 1.57
    rCSI 2.77%
    PRS 93.95
  • endothelial cell of vascular tree CL0002139
    CSI 1.38
    rCSI 7.56%
    PRS 87.76
  • pulmonary alveolar type 1 cell CL0002062
    CSI 1.2
    rCSI 6.91%
    PRS 89.01
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.14
    rCSI 2.02%
    PRS 79.08
  • retinal ganglion cell CL0000740
    CSI 1.04
    rCSI 2.29%
    PRS 81.99
  • blood vessel smooth muscle cell CL0019018
    CSI 0.97
    rCSI 7.86%
    PRS 89.37
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.9
    rCSI 2.82%
    PRS 82.65
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.63
    rCSI 3.94%
    PRS 85.77
  • ON parasol ganglion cell CL4033052
    CSI 0.43
    rCSI 6.07%
    PRS 84.75
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.36
    rCSI 8.68%
    PRS 77.64
  • ON midget ganglion cell CL4033046
    CSI 0.34
    rCSI 7.03%
    PRS 83.67
  • OFF midget ganglion cell CL4033047
    CSI 0.31
    rCSI 6.28%
    PRS 84.31
  • direct pathway medium spiny neuron CL4023026
    CSI 0.25
    rCSI 5.93%
    PRS 77.48

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary `[RBMS3 AS3](/details-gene/100873979)` is a non-coding antisense RNA located on chromosome 3p24.1. Its expression profile suggests a primary role in defining the identity and function of various mesenchymal and stromal cell types. **Overall**, it is most significantly expressed in `[fibroblast of lung](/details-cell/CL0002553)`, `[inhibitory interneuron](/details-cell/CL0000498)`, `[adipocyte](/details-cell/CL0000136)`, and `[smooth muscle cell](/details-cell/CL0000192)`. This pattern indicates potential involvement in tissue structure, metabolic regulation, and specialized neural functions, likely through the regulation of its sense-strand counterpart, `[RBMS3](/details-gene/27303)`. ## Cellular Roles and Expression Landscape The expression landscape of `[RBMS3 AS3](/details-gene/100873979)` highlights its prominence in cells of mesenchymal origin. It serves as a top marker in `[fibroblast of lung](/details-cell/CL0002553)` (CSI: 13.66), with significant expression also observed in other fibroblast subtypes such as `[alveolar adventitial fibroblast](/details-cell/CL4028006)` and `[alveolar type 1 fibroblast cell](/details-cell/CL4028004)`. This strong association with fibroblasts suggests a role in maintaining connective tissue homeostasis and response to injury. Beyond fibroblasts, `[RBMS3 AS3](/details-gene/100873979)` shows high significance in multiple types of fat cells, including general `[adipocyte](/details-cell/CL0000136)`, `[epicardial adipocyte](/details-cell/CL1000309)`, and `[subcutaneous adipocyte](/details-cell/CL0002521)`, pointing towards a potential function in adipogenesis or lipid metabolism. The gene is also highly expressed in contractile and vascular cells, such as `[smooth muscle cell](/details-cell/CL0000192)`, `[cardiac muscle cell](/details-cell/CL0000746)`, `[blood vessel endothelial cell](/details-cell/CL0000071)`, and `[pericyte](/details-cell/CL0000669)`, indicating a broad role in the cardiovascular system. Interestingly, `[RBMS3 AS3](/details-gene/100873979)` also exhibits high specificity in a non-mesenchymal lineage: `[inhibitory interneuron](/details-cell/CL0000498)` (CSI: 11.08), including `[pvalb GABAergic cortical interneuron](/details-cell/CL4023018)`. This suggests a specialized, and as yet uncharacterized, role in the regulation of neuronal function, possibly related to specifying the identity or activity of this particular neuronal subtype. ## Pathways and Molecular Function As an antisense non-coding RNA, the primary molecular function of `[RBMS3 AS3](/details-gene/100873979)` is predicted to be the post-transcriptional or transcriptional regulation of its sense-strand counterpart, `[RBMS3](/details-gene/27303)` (RNA Binding Motif Single Stranded Interacting Protein 3). This regulation could occur through mechanisms such as mRNA masking, translational repression, or directing epigenetic modifications. While specific pathway annotations for `[RBMS3 AS3](/details-gene/100873979)` are limited, its cellular expression profile allows for functional inference. Its high levels in fibroblasts, smooth muscle cells, and cardiac muscle cells suggest a potential role in pathways related to extracellular matrix organization, cell adhesion, and tissue development. Its expression in adipocytes is consistent with involvement in metabolic pathways, such as triglyceride metabolism and insulin signaling. In inhibitory neurons, it may modulate pathways governing synaptic transmission and neuronal plasticity. The precise molecular consequences of its regulatory activity on `[RBMS3](/details-gene/27303)` within these cellular contexts remain to be elucidated. ## Research Directions The highly specific expression pattern of `[RBMS3 AS3](/details-gene/100873979)` provides a strong foundation for investigating its role in both normal physiology and disease. **Proposed Hypotheses:** 1. Given its top-ranking significance in multiple fibroblast populations, `[RBMS3 AS3](/details-gene/100873979)` may function as a master regulator of fibroblast activation and fibrogenesis. Dysregulation of this lncRNA could be a key event in the pathogenesis of fibrotic diseases like idiopathic pulmonary fibrosis (IPF). 2. The high expression of `[RBMS3 AS3](/details-gene/100873979)` across various adipocyte subtypes suggests it is involved in adipocyte differentiation or metabolic homeostasis. Its modulation could impact lipid storage and sensitivity to metabolic hormones. 3. Its specific and high expression in `[inhibitory interneuron](/details-cell/CL0000498)` indicates a potential role in establishing or maintaining the functional identity of this neuronal class, possibly by fine-tuning the expression of genes essential for GABAergic signaling. **Suggested Experimental Approach:** To test the hypothesis that `[RBMS3 AS3](/details-gene/100873979)` is a key regulator of fibroblast function (Hypothesis 1), a loss-of-function study could be performed. Primary human lung fibroblasts could be treated with antisense oligonucleotides (ASOs) specifically targeting `[RBMS3 AS3](/details-gene/100873979)`. The effects of its knockdown on fibroblast activation could be assessed by measuring changes in the expression of alpha-smooth muscle actin (α-SMA) and collagen type I upon TGF-β stimulation. Furthermore, RNA-sequencing could be performed on knockdown cells to identify downstream targets, including the `[RBMS3](/details-gene/27303)` sense transcript, and to reveal the broader gene regulatory networks it controls. **Therapeutic Potential:** As a long non-coding RNA, `[RBMS3 AS3](/details-gene/100873979)` represents a novel class of therapeutic targets. Its high and specific expression in fibroblasts makes it an attractive candidate for therapies aimed at mitigating fibrosis. An **inhibitory** strategy using ASO-based therapeutics could potentially reduce the pathological activation of fibroblasts in diseases like IPF or systemic sclerosis. However, its significant expression in other critical cell types, such as cardiac muscle and neurons, necessitates a thorough evaluation of potential off-target effects before clinical consideration.