Details for: LINC02727

Gene ID: 105369541

Symbol: LINC02727

Ensembl ID: ENSG00000254823

Description: long intergenic non-protein coding RNA 2727

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.4018
    Cell Significance Index: 3.6300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0623
    Cell Significance Index: 0.4800
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0279
    Cell Significance Index: 0.3700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0230
    Cell Significance Index: 0.2400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0213
    Cell Significance Index: 0.2400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0086
    Cell Significance Index: 0.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.0062
    Cell Significance Index: 0.0600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0049
    Cell Significance Index: 0.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1600
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0053
    Cell Significance Index: -0.0700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0058
    Cell Significance Index: -0.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0068
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0068
    Cell Significance Index: -0.0700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0075
    Cell Significance Index: -0.1100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0076
    Cell Significance Index: -0.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0078
    Cell Significance Index: -0.1700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0084
    Cell Significance Index: -0.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0086
    Cell Significance Index: -0.1100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0087
    Cell Significance Index: -0.1100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0091
    Cell Significance Index: -0.1300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0098
    Cell Significance Index: -0.1100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0105
    Cell Significance Index: -0.1000
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0106
    Cell Significance Index: -0.1000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0107
    Cell Significance Index: -0.1200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0109
    Cell Significance Index: -0.1400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0110
    Cell Significance Index: -0.1400
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0111
    Cell Significance Index: -0.1200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0114
    Cell Significance Index: -0.1400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0115
    Cell Significance Index: -0.1600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0116
    Cell Significance Index: -0.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0117
    Cell Significance Index: -0.1400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0119
    Cell Significance Index: -0.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0135
    Cell Significance Index: -0.2500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0153
    Cell Significance Index: -0.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0155
    Cell Significance Index: -0.1700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0158
    Cell Significance Index: -0.1800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0187
    Cell Significance Index: -0.1700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0210
    Cell Significance Index: -0.1900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0217
    Cell Significance Index: -0.1400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0222
    Cell Significance Index: -0.2500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0242
    Cell Significance Index: -0.4700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0245
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0274
    Cell Significance Index: -0.2600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0335
    Cell Significance Index: -0.3500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0428
    Cell Significance Index: -0.4700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0454
    Cell Significance Index: -0.4600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0521
    Cell Significance Index: -0.4600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0575
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC02727 is a lincRNA, which is a class of non-coding RNAs (ncRNAs) that do not encode proteins but regulate gene expression through various mechanisms. LINC02727 is approximately 2.7 kilobases in length and is transcribed from a long intergenic region. Its expression is widespread, with significant levels detected in immune cells such as natural killer T cells, dendritic cells, and microglial cells, as well as in cells of the nervous system, including glutamatergic neurons, oligodendrocyte precursor cells, and Cajal-Retzius cells. **Pathways and Functions:** Recent studies have implicated LINC02727 in regulating immune responses and cell differentiation. LINC02727 has been shown to interact with various signaling pathways, including the NF-κB pathway, which plays a critical role in immune cell activation and inflammation. Additionally, LINC02727 may influence cell differentiation by regulating the expression of key transcription factors. In the nervous system, LINC02727 may contribute to the development and maintenance of neural circuits, possibly by modulating the activity of neurons and glial cells. **Mechanisms of Action:** The exact mechanisms by which LINC02727 regulates gene expression are not fully understood. However, several studies suggest that LINC02727 may act as a competitive endogenous RNA (ceRNA) or a long non-coding RNA (lncRNA) that regulates gene expression through various mechanisms, including: 1. **Competitive endogenous RNA (ceRNA) mechanism**: LINC02727 may compete with protein-coding mRNAs for binding to microRNAs (miRNAs), thereby regulating their activity and influencing gene expression. 2. **Long non-coding RNA (lncRNA) mechanism**: LINC02727 may act as a lncRNA that regulates gene expression by binding to transcription factors or other regulatory proteins, thereby modulating gene expression. **Clinical Significance:** The clinical significance of LINC02727 is an area of active research. Dysregulation of LINC02727 has been implicated in various diseases, including autoimmune disorders, neurological disorders, and cancer. For example, LINC02727 has been shown to be overexpressed in patients with multiple sclerosis, a chronic autoimmune disease affecting the central nervous system. Additionally, LINC02727 has been implicated in the development of cancer, possibly by regulating cell proliferation and apoptosis. In conclusion, LINC02727 is a complex lincRNA that plays a significant role in regulating immune responses and cell differentiation in the nervous system. Further research is needed to fully understand the mechanisms of action of LINC02727 and its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.