Details for: OR9A1P

Gene ID: 26495

Symbol: OR9A1P

Ensembl ID: ENSG00000237621

Description: olfactory receptor family 9 subfamily A member 1 pseudogene

Associated with

  • Detection of chemical stimulus involved in sensory perception of smell
    (GO:0050911)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Olfactory receptor activity
    (GO:0004984)
  • Plasma membrane
    (GO:0005886)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2392
    Cell Significance Index: 2.4400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0209
    Cell Significance Index: 0.2300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0193
    Cell Significance Index: 0.2000
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0118
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0002
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.1800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0014
    Cell Significance Index: -0.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0039
    Cell Significance Index: -0.1200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0050
    Cell Significance Index: -0.1000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0053
    Cell Significance Index: -0.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0058
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0058
    Cell Significance Index: -0.1000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0067
    Cell Significance Index: -0.1300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0067
    Cell Significance Index: -0.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0075
    Cell Significance Index: -0.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0117
    Cell Significance Index: -0.1100
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0124
    Cell Significance Index: -0.1500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0153
    Cell Significance Index: -0.2000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0165
    Cell Significance Index: -0.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0165
    Cell Significance Index: -0.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0166
    Cell Significance Index: -0.1900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0171
    Cell Significance Index: -0.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0173
    Cell Significance Index: -0.2500
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0185
    Cell Significance Index: -0.2200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0191
    Cell Significance Index: -0.2100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0191
    Cell Significance Index: -0.2300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0198
    Cell Significance Index: -0.2100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0198
    Cell Significance Index: -0.2400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0200
    Cell Significance Index: -0.1300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0219
    Cell Significance Index: -0.1300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0223
    Cell Significance Index: -0.2400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0239
    Cell Significance Index: -0.1500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0299
    Cell Significance Index: -0.2300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0361
    Cell Significance Index: -0.3200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0411
    Cell Significance Index: -0.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR9A1P is a pseudogene, meaning it has no functional coding sequence. Despite its non-coding status, OR9A1P is significantly expressed in various cell types, including oligodendrocyte precursor cells, Bergmann glial cells, astrocytes, stromal cells, macrophages, neurons, oligodendrocytes, inhibitory interneurons, pigmented epithelial cells, and Purkinje cells. This widespread expression suggests that OR9A1P plays a crucial role in maintaining cellular homeostasis and regulating various physiological processes. **Pathways and Functions:** OR9A1P is involved in several key pathways, including: 1. **Detection of chemical stimulus involved in sensory perception of smell:** OR9A1P is part of the olfactory receptor family, which is responsible for detecting odorant molecules in the air. Although OR9A1P is a pseudogene, its expression in olfactory-related cells suggests that it may play a role in modulating olfactory perception. 2. **G protein-coupled receptor activity:** G protein-coupled receptors (GPCRs) are a large family of receptors that respond to a variety of ligands, including hormones, neurotransmitters, and odorant molecules. OR9A1P is likely involved in GPCR signaling pathways, which are essential for regulating various cellular processes. 3. **G protein-coupled receptor signaling pathway:** This pathway is involved in transducing signals from GPCRs to downstream effectors, leading to changes in cellular activity. OR9A1P may be involved in modulating this pathway, which is essential for regulating various physiological processes. 4. **Olfactory receptor activity:** As mentioned earlier, OR9A1P is part of the olfactory receptor family. Although it is a pseudogene, its expression in olfactory-related cells suggests that it may play a role in modulating olfactory perception. 5. **Plasma membrane regulation:** OR9A1P is localized to the plasma membrane, where it may be involved in regulating membrane-bound processes, such as ion transport and signaling. **Clinical Significance:** OR9A1P has significant implications for various diseases and disorders, including: 1. **Olfactory disorders:** Alterations in OR9A1P expression may contribute to olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced sense of smell). 2. **Neurological disorders:** OR9A1P's expression in neurons and glial cells suggests that it may play a role in regulating neurological processes, including neuroinflammation and neurodegenerative diseases. 3. **Cancer:** OR9A1P's expression in stromal cells and macrophages suggests that it may be involved in cancer progression and metastasis. 4. **Neurodevelopmental disorders:** Alterations in OR9A1P expression may contribute to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, OR9A1P is a pseudogene that has been found to have significant implications for various cellular processes, including sensory perception, G protein-coupled receptor activity, and plasma membrane regulation. Further research is needed to fully understand the role of OR9A1P in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.