Details for: OR7C2

Gene ID: 26658

Symbol: OR7C2

Ensembl ID: ENSG00000127529

Description: olfactory receptor family 7 subfamily C member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.8056
    Cell Significance Index: 147.9100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 4.1890
    Cell Significance Index: 67.8500
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.6204
    Cell Significance Index: 21.3200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.0786
    Cell Significance Index: 13.9600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.5991
    Cell Significance Index: 10.2400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.5516
    Cell Significance Index: 5.8600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3383
    Cell Significance Index: 4.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0922
    Cell Significance Index: 1.3200
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0494
    Cell Significance Index: 0.5300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0289
    Cell Significance Index: 0.3800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0032
    Cell Significance Index: 0.0300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0028
    Cell Significance Index: 0.0200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0033
    Cell Significance Index: -0.0300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0116
    Cell Significance Index: -0.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0495
    Cell Significance Index: -0.9900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0498
    Cell Significance Index: -0.7200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0598
    Cell Significance Index: -0.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0619
    Cell Significance Index: -1.6500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1150
    Cell Significance Index: -1.4100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1167
    Cell Significance Index: -1.3700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1314
    Cell Significance Index: -1.3000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1332
    Cell Significance Index: -1.4300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1365
    Cell Significance Index: -1.6100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1627
    Cell Significance Index: -1.9500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1652
    Cell Significance Index: -1.5500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1716
    Cell Significance Index: -2.0300
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1744
    Cell Significance Index: -1.8500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1910
    Cell Significance Index: -1.1300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2048
    Cell Significance Index: -2.1600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.2234
    Cell Significance Index: -2.6500
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.2517
    Cell Significance Index: -2.8000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2636
    Cell Significance Index: -3.4600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2859
    Cell Significance Index: -1.7800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3403
    Cell Significance Index: -3.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3424
    Cell Significance Index: -3.7300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5169
    Cell Significance Index: -11.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.8291
    Cell Significance Index: -16.2100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.2917
    Cell Significance Index: -16.3000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -1.4916
    Cell Significance Index: -16.3400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -1.4995
    Cell Significance Index: -16.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -1.5884
    Cell Significance Index: -15.2700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -1.6044
    Cell Significance Index: -16.2800
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -2.1313
    Cell Significance Index: -17.5900
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -2.3528
    Cell Significance Index: -20.5800
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -2.4039
    Cell Significance Index: -16.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR7C2 is a functional olfactory receptor that binds to specific odorants, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **G Protein-Coupled Receptor (GPCR) Family:** As a GPCR, OR7C2 is part of a large family of receptors that respond to external signals by activating G proteins, which in turn modulate downstream signaling pathways. 3. **Wide Tissue Expression:** OR7C2 is expressed in various cell types, including hematopoietic stem cells, mast cells, and cardiac endothelial cells, indicating its involvement in multiple physiological processes. 4. **Signaling Pathways:** OR7C2 is involved in multiple signaling pathways, including the detection of chemical stimuli, expression and translocation of olfactory receptors, and signal transduction. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR7C2 plays a critical role in detecting chemical stimuli involved in sensory perception of smell. Upon binding to an odorant, OR7C2 triggers a signaling cascade that activates downstream pathways, leading to the perception of smell. 2. **Expression and Translocation of Olfactory Receptors:** OR7C2 is involved in the expression and translocation of olfactory receptors, which is essential for the development and maintenance of the olfactory system. 3. **G Protein-Coupled Receptor Activity:** As a GPCR, OR7C2 activates G proteins, which modulate downstream signaling pathways, including the detection of chemical stimuli and signal transduction. 4. **Olfactory Signaling Pathway:** OR7C2 is part of the olfactory signaling pathway, which involves the coordination of multiple olfactory receptors to detect and distinguish various smells. 5. **Signal Transduction:** OR7C2 is involved in signal transduction, which is the process by which a cell responds to a stimulus, in this case, the binding of an odorant to the receptor. **Clinical Significance:** 1. **Olfactory Disorders:** Mutations in the OR7C2 gene have been associated with olfactory disorders, such as anosmia and hyposmia, which can have significant impacts on quality of life. 2. **Neurological Disorders:** OR7C2 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where olfactory dysfunction is a common feature. 3. **Cancer Research:** OR7C2 has been identified as a potential biomarker for cancer, as its expression is altered in various types of cancer, including lung, breast, and colon cancer. 4. **Immunological Disorders:** OR7C2 has been implicated in immunological disorders, such as asthma and allergic rhinitis, where olfactory dysfunction is a common feature. In conclusion, the OR7C2 gene plays a critical role in the detection of chemical stimuli involved in sensory perception of smell and is involved in various signaling pathways, including the expression and translocation of olfactory receptors and signal transduction. Its clinical significance extends to olfactory disorders, neurological disorders, cancer research, and immunological disorders, highlighting the importance of OR7C2 in maintaining normal physiological function and its potential as a biomarker for various diseases.

Genular Protein ID: 874094093

Symbol: OR7C2_HUMAN

Name: Olfactory receptor 7C2

UniProtKB Accession Codes:

O60412 O43881 Q6IFP9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 Ensembl 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 9500546

Title: Distribution of olfactory receptor genes in the human genome.

PubMed ID: 9500546

DOI: 10.1038/ng0398-243

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 319
  • Mass: 35323
  • Checksum: 1FAF5A196B2B566C
  • Sequence:
    • MERGNQTEVG NFLLLGFAED SDMQLLLHGL FLSMYLVTII GNLLIILTIS SDSHLHTPMY 
FFLSNLSFAD ICFTSTTVPK MLVNIQTQSK MITFAGCLTQ IFFFIAFGCL DNLLLTMTAY 
DRFVAICYPL HYTVIMNPRL CGLLVLGSWC ISVMGSLLET LTILRLSFCT NMEIPHFFCD 
PSEVLKLACS DTFINNIVMY FVTIVLGVFP LCGILFSYSQ IFSSVLRVSA RGQHKAFSTC 
GSHLSVVSLF YGTGLGVYLS SAVTPPSRTS LAASVMYTMV TPMLNPFIYS LRNKDMKGSL 
GRLLLRATSL KEGTIAKLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.