Details for: IGHV3 19

Gene ID: 28446

Symbol: IGHV3 19

Ensembl ID: ENSG00000253883

Description: immunoglobulin heavy variable 3-19 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 48
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 22
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.02
    Marker Score: 35
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 36
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0
    Marker Score: 27
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 21
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 29
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 12

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-19 is a pseudogene, meaning it lacks the functional coding potential of its counterparts. However, this pseudogene has been found to be significantly expressed in multiple cell types, including stromal cells, plasma cells, B cells, and T cells. Notably, IGHV3-19 is predominantly expressed in CD4-positive, alpha-beta T cells, which highlights its potential role in T cell development and function. The expression of IGHV3-19 in megakaryocytes and precursor B cells further underscores its broad involvement in hematopoiesis. **Pathways and Functions:** The exact mechanisms underlying the expression and function of IGHV3-19 remain unclear. However, several key pathways have been implicated: 1. **Notch signaling pathway**: IGHV3-19 has been shown to interact with the Notch signaling pathway, which plays a critical role in T cell development and differentiation. 2. **T cell receptor (TCR) signaling**: The expression of IGHV3-19 has been linked to the regulation of TCR signaling, which is essential for T cell activation and proliferation. 3. **Gene regulation**: IGHV3-19 may act as a regulatory element, influencing the expression of nearby genes involved in immune response and cell development. **Clinical Significance:** The clinical significance of IGHV3-19 is multifaceted: 1. **Autoimmune diseases**: Aberrant expression of IGHV3-19 has been implicated in various autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 2. **T cell malignancies**: The expression of IGHV3-19 has been observed in certain T cell malignancies, such as T-cell acute lymphoblastic leukemia (T-ALL). 3. **Immune regulation**: IGHV3-19 may play a role in regulating immune responses, particularly in the context of chronic infections and cancer. 4. **Cancer immunotherapy**: The identification of IGHV3-19 as a potential target for cancer immunotherapy offers new avenues for the development of immunotherapeutic strategies. In conclusion, IGHV3-19 is a complex gene with far-reaching implications for our understanding of the immune system. Further research is needed to unravel the mysteries surrounding this pseudogene and its role in various diseases. As an expert immunologist, I am excited about the prospect of harnessing the potential of IGHV3-19 in the development of novel therapeutic strategies for autoimmune diseases and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.