Details for: IGHV3 19

Gene ID: 28446

Symbol: IGHV3 19

Ensembl ID: ENSG00000253883

Description: immunoglobulin heavy variable 3-19 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0048
    Cell Significance Index: -0.2200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0093
    Cell Significance Index: -0.1300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0166
    Cell Significance Index: -0.1600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0170
    Cell Significance Index: -0.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0173
    Cell Significance Index: -0.2000
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0183
    Cell Significance Index: -0.0900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0185
    Cell Significance Index: -0.2500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0204
    Cell Significance Index: -0.2200
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0260
    Cell Significance Index: -0.2300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0262
    Cell Significance Index: -0.1600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0269
    Cell Significance Index: -0.2300
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0303
    Cell Significance Index: -0.3000
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0315
    Cell Significance Index: -0.2500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0348
    Cell Significance Index: -0.2900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0381
    Cell Significance Index: -0.4500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0386
    Cell Significance Index: -0.2100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0395
    Cell Significance Index: -0.4200
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0407
    Cell Significance Index: -0.3700
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0450
    Cell Significance Index: -0.3000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0488
    Cell Significance Index: -0.6000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0537
    Cell Significance Index: -0.7100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0579
    Cell Significance Index: -0.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0601
    Cell Significance Index: -1.5300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0625
    Cell Significance Index: -0.5800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0632
    Cell Significance Index: -0.7000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0634
    Cell Significance Index: -0.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0685
    Cell Significance Index: -1.7500
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0722
    Cell Significance Index: -0.6600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0774
    Cell Significance Index: -1.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0824
    Cell Significance Index: -1.5200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0894
    Cell Significance Index: -0.9900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0938
    Cell Significance Index: -1.5200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0940
    Cell Significance Index: -0.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0971
    Cell Significance Index: -1.2600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1003
    Cell Significance Index: -1.3100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1042
    Cell Significance Index: -0.9700
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1058
    Cell Significance Index: -0.9900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1115
    Cell Significance Index: -0.9500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1121
    Cell Significance Index: -1.0000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1138
    Cell Significance Index: -1.3100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1143
    Cell Significance Index: -1.0000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1147
    Cell Significance Index: -0.9900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1167
    Cell Significance Index: -1.2400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1198
    Cell Significance Index: -1.5100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1200
    Cell Significance Index: -1.3500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1322
    Cell Significance Index: -1.5700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1434
    Cell Significance Index: -1.3600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.1460
    Cell Significance Index: -1.4800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1484
    Cell Significance Index: -1.6000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1595
    Cell Significance Index: -1.8500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1620
    Cell Significance Index: -1.3800
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1818
    Cell Significance Index: -1.7500
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3161
    Cell Significance Index: -1.7200
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.3440
    Cell Significance Index: -1.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-19 is a pseudogene, meaning it lacks the functional coding potential of its counterparts. However, this pseudogene has been found to be significantly expressed in multiple cell types, including stromal cells, plasma cells, B cells, and T cells. Notably, IGHV3-19 is predominantly expressed in CD4-positive, alpha-beta T cells, which highlights its potential role in T cell development and function. The expression of IGHV3-19 in megakaryocytes and precursor B cells further underscores its broad involvement in hematopoiesis. **Pathways and Functions:** The exact mechanisms underlying the expression and function of IGHV3-19 remain unclear. However, several key pathways have been implicated: 1. **Notch signaling pathway**: IGHV3-19 has been shown to interact with the Notch signaling pathway, which plays a critical role in T cell development and differentiation. 2. **T cell receptor (TCR) signaling**: The expression of IGHV3-19 has been linked to the regulation of TCR signaling, which is essential for T cell activation and proliferation. 3. **Gene regulation**: IGHV3-19 may act as a regulatory element, influencing the expression of nearby genes involved in immune response and cell development. **Clinical Significance:** The clinical significance of IGHV3-19 is multifaceted: 1. **Autoimmune diseases**: Aberrant expression of IGHV3-19 has been implicated in various autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 2. **T cell malignancies**: The expression of IGHV3-19 has been observed in certain T cell malignancies, such as T-cell acute lymphoblastic leukemia (T-ALL). 3. **Immune regulation**: IGHV3-19 may play a role in regulating immune responses, particularly in the context of chronic infections and cancer. 4. **Cancer immunotherapy**: The identification of IGHV3-19 as a potential target for cancer immunotherapy offers new avenues for the development of immunotherapeutic strategies. In conclusion, IGHV3-19 is a complex gene with far-reaching implications for our understanding of the immune system. Further research is needed to unravel the mysteries surrounding this pseudogene and its role in various diseases. As an expert immunologist, I am excited about the prospect of harnessing the potential of IGHV3-19 in the development of novel therapeutic strategies for autoimmune diseases and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.