Details for: TRAJ34

Gene ID: 28721

Symbol: TRAJ34

Ensembl ID: ENSG00000211855

Description: T cell receptor alpha joining 34

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0274
    Cell Significance Index: 0.3100
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0177
    Cell Significance Index: 0.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0006
    Cell Significance Index: 0.0300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0046
    Cell Significance Index: -0.0800
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0064
    Cell Significance Index: -0.0500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0072
    Cell Significance Index: -0.0900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0165
    Cell Significance Index: -0.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0193
    Cell Significance Index: -0.2300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0206
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0209
    Cell Significance Index: -0.1900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0237
    Cell Significance Index: -0.3100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0245
    Cell Significance Index: -0.2100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0252
    Cell Significance Index: -0.3400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0262
    Cell Significance Index: -0.2900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0274
    Cell Significance Index: -0.2800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0296
    Cell Significance Index: -0.3000
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0302
    Cell Significance Index: -0.3500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0304
    Cell Significance Index: -0.3500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0314
    Cell Significance Index: -0.3800
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0318
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0321
    Cell Significance Index: -0.3000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0327
    Cell Significance Index: -0.3300
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0330
    Cell Significance Index: -0.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0338
    Cell Significance Index: -0.3300
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0351
    Cell Significance Index: -0.3500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0359
    Cell Significance Index: -0.3100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0360
    Cell Significance Index: -0.2800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0365
    Cell Significance Index: -0.3700
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0389
    Cell Significance Index: -0.3400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0391
    Cell Significance Index: -0.3600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0393
    Cell Significance Index: -0.3500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0400
    Cell Significance Index: -0.4500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0403
    Cell Significance Index: -0.3400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0413
    Cell Significance Index: -0.4500
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0419
    Cell Significance Index: -0.3500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0421
    Cell Significance Index: -0.8300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0429
    Cell Significance Index: -0.4800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0432
    Cell Significance Index: -0.3500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0439
    Cell Significance Index: -0.4700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0443
    Cell Significance Index: -0.4300
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0461
    Cell Significance Index: -0.4100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0463
    Cell Significance Index: -0.3700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0470
    Cell Significance Index: -0.3500
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0480
    Cell Significance Index: -0.3300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0482
    Cell Significance Index: -0.6200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0487
    Cell Significance Index: -0.4500
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0553
    Cell Significance Index: -0.5500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0573
    Cell Significance Index: -0.7600
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0595
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0637
    Cell Significance Index: -0.6000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0639
    Cell Significance Index: -0.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ34 is a gene that belongs to the TRAJ family of genes, which are involved in the assembly of the T cell receptor complex. The TRAJ34 gene is specifically expressed in T cells, with a broad tissue distribution including CD8-positive, alpha-beta T cells, innate lymphoid cells, and mature alpha-beta T cells. The expression of TRAJ34 is tightly regulated during T cell development, with significant expression observed in thymocytes and mature T cells. The protein product of TRAJ34, TCR alpha joining 34, plays a critical role in the joining of the T cell receptor alpha chain to the T cell receptor beta chain, a process that is essential for the formation of the T cell receptor complex. **Pathways and Functions:** The TRAJ34 gene is involved in the following pathways and functions: 1. **T cell receptor complex assembly:** TRAJ34 plays a critical role in the assembly of the T cell receptor complex, which is essential for the recognition of antigens and the activation of T cells. 2. **T cell development:** TRAJ34 is expressed during T cell development, including in thymocytes and mature T cells, and is involved in the regulation of T cell development and maturation. 3. **T cell activation:** TRAJ34 is involved in the activation of T cells, including the activation of CD8-positive, alpha-beta T cells and innate lymphoid cells. 4. **Immune regulation:** TRAJ34 is involved in the regulation of immune responses, including the regulation of T cell-mediated immunity and the prevention of autoimmune disease. **Clinical Significance:** The TRAJ34 gene has significant clinical implications, including: 1. **Immunodeficiency:** Mutations in the TRAJ34 gene have been associated with immunodeficiency disorders, including severe combined immunodeficiency (SCID). 2. **Cancer:** TRAJ34 has been implicated in the development and progression of certain types of cancer, including T cell lymphoma. 3. **Autoimmune disease:** TRAJ34 has been implicated in the regulation of autoimmune disease, including rheumatoid arthritis and multiple sclerosis. 4. **Immunotherapy:** Understanding the role of TRAJ34 in T cell development and function is crucial for the development of novel immunotherapeutic strategies, including cancer immunotherapy and vaccine development. In conclusion, TRAJ34 is a critical gene that plays a pivotal role in the development and function of T cells. Understanding the role of TRAJ34 in T cell development and function is essential for the development of novel immunotherapeutic strategies and the treatment of immunodeficiency disorders, cancer, and autoimmune disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.