Details for: TRAJ28

Gene ID: 28727

Symbol: TRAJ28

Ensembl ID: ENSG00000211861

Description: T cell receptor alpha joining 28

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.0903
    Cell Significance Index: 0.7500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0319
    Cell Significance Index: 0.3600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0034
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0007
    Cell Significance Index: 0.2500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0020
    Cell Significance Index: -0.0900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0039
    Cell Significance Index: -0.0800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0051
    Cell Significance Index: -0.0600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0056
    Cell Significance Index: -0.1100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0064
    Cell Significance Index: -0.0500
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0075
    Cell Significance Index: -0.0800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0089
    Cell Significance Index: -0.1200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0093
    Cell Significance Index: -0.1100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0096
    Cell Significance Index: -0.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0101
    Cell Significance Index: -0.1200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0103
    Cell Significance Index: -0.1300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0108
    Cell Significance Index: -0.0900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0127
    Cell Significance Index: -0.1200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0135
    Cell Significance Index: -0.1500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0138
    Cell Significance Index: -0.1600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0144
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0146
    Cell Significance Index: -0.1400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0148
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0148
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0150
    Cell Significance Index: -0.1700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0151
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0155
    Cell Significance Index: -0.1500
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0158
    Cell Significance Index: -0.1600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0159
    Cell Significance Index: -0.1600
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0160
    Cell Significance Index: -0.1600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0161
    Cell Significance Index: -0.1700
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0163
    Cell Significance Index: -0.1900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0170
    Cell Significance Index: -0.1600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0171
    Cell Significance Index: -0.1500
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0172
    Cell Significance Index: -0.1500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0174
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0183
    Cell Significance Index: -0.1900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0186
    Cell Significance Index: -0.2200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0187
    Cell Significance Index: -0.1700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0194
    Cell Significance Index: -0.2000
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0195
    Cell Significance Index: -0.1600
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0198
    Cell Significance Index: -0.1600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0202
    Cell Significance Index: -0.1100
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0215
    Cell Significance Index: -0.1600
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0224
    Cell Significance Index: -0.2000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0233
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0244
    Cell Significance Index: -0.2200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0260
    Cell Significance Index: -0.3200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0281
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0282
    Cell Significance Index: -0.2200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0525
    Cell Significance Index: -0.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ28 is a member of the TRAJ family of genes, which are known to contribute to the development and function of T cells. The TRAJ28 gene encodes a protein that is predicted to interact with the T cell receptor (TCR) complex, specifically the alpha chain of the TCR. This interaction is crucial for the proper assembly and function of the TCR, which is essential for the activation and regulation of immune responses. TRAJ28 is highly expressed in various immune cells, including CD8+ T cells, alpha-beta T cells, innate lymphoid cells, and CD4+ T cells, suggesting its widespread involvement in immune regulation. **Pathways and Functions:** TRAJ28 is involved in several key signaling pathways that regulate immune responses. These include: 1. **TCR signaling pathway:** TRAJ28 interacts with the TCR complex, facilitating the activation of T cells in response to antigen presentation. 2. **Notch signaling pathway:** TRAJ28 has been shown to interact with the Notch signaling pathway, which is crucial for the development and differentiation of T cells. 3. **JAK/STAT signaling pathway:** TRAJ28 has been implicated in the regulation of the JAK/STAT signaling pathway, which is involved in the production of cytokines and the regulation of immune responses. The functions of TRAJ28 are multifaceted, including: 1. **T cell development and differentiation:** TRAJ28 plays a crucial role in the development and differentiation of T cells, particularly in the context of CD4+ and CD8+ T cell development. 2. **Immune activation and regulation:** TRAJ28 is involved in the activation and regulation of immune responses, particularly in the context of T cell activation and cytokine production. 3. **Immune tolerance and homeostasis:** TRAJ28 has been implicated in the regulation of immune tolerance and homeostasis, particularly in the context of the maintenance of peripheral tolerance. **Clinical Significance:** Dysregulation of TRAJ28 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** TRAJ28 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer:** TRAJ28 has been implicated in the regulation of immune responses in the context of cancer, particularly in the context of tumor immune evasion. 3. **Infectious diseases:** TRAJ28 has been implicated in the regulation of immune responses in the context of infectious diseases, particularly in the context of viral infections. In conclusion, TRAJ28 is a critical gene that plays a pivotal role in the development and function of various immune cells. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of further research into the mechanisms of TRAJ28 and its role in immune regulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.