Details for: IGLV2 33

Gene ID: 28811

Symbol: IGLV2 33

Ensembl ID: ENSG00000211656

Description: immunoglobulin lambda variable 2-33 (non-functional)

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.63
    Marker Score: 10,811
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.25
    Marker Score: 7,576
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3,656
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32,728
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,406
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,347
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 742
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.38
    Marker Score: 365
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 378
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 50
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.04
    Marker Score: 10
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.02
    Marker Score: 14
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 24
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 16

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional gene**: IGLV2 33 is a non-functional gene, meaning it does not produce a functional protein that can bind to antigens. 2. **Immunoglobulin lambda variable gene**: IGLV2 33 belongs to the immunoglobulin lambda variable gene family, which encodes the variable region of the lambda light chain of immunoglobulins. 3. **Significant expression in various cell types**: IGLV2 33 is expressed in goblet cells, neoplastic cells, and intestinal epithelial cells, among others. 4. **Adaptive immune response**: IGLV2 33 is involved in the adaptive immune response, which is a specific and targeted response to pathogens. **Pathways and Functions:** 1. **Adaptive immune response**: IGLV2 33 contributes to the adaptive immune response by regulating the activity of B cells and other immune cells. 2. **Immune regulation**: IGLV2 33 may play a role in regulating the immune response, particularly in the context of tolerance and homeostasis. 3. **Tissue homeostasis**: IGLV2 33 is expressed in intestinal epithelial cells, suggesting that it may contribute to tissue homeostasis and the maintenance of the gut barrier. 4. **Immunoglobulin production**: Although IGLV2 33 is non-functional, it may still influence the production of immunoglobulins by regulating the expression of other genes involved in the immune response. **Clinical Significance:** 1. **Immune-related disorders**: Abnormal expression of IGLV2 33 has been linked to immune-related disorders, such as autoimmune diseases and cancer. 2. **Gastrointestinal diseases**: IGLV2 33 expression in intestinal epithelial cells may contribute to the pathogenesis of gastrointestinal diseases, such as inflammatory bowel disease (IBD). 3. **Cancer**: Non-functional IGLV2 33 may still influence the development and progression of cancer by regulating the immune response and tissue homeostasis. 4. **Immunotherapy**: Understanding the role of IGLV2 33 in the adaptive immune response may provide insights into the development of immunotherapies for cancer and other immune-related disorders. In conclusion, IGLV2 33 is a non-functional gene that plays a crucial role in the adaptive immune response and tissue homeostasis. Its significant expression in various cell types and involvement in immune regulation and disease suggest that it is a key player in the immune system. Further studies are needed to fully elucidate the role of IGLV2 33 in immune-related disorders and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.