Details for: IGLV2 33

Gene ID: 28811

Symbol: IGLV2 33

Ensembl ID: ENSG00000211656

Description: immunoglobulin lambda variable 2-33 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.0718
    Cell Significance Index: 0.9800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0304
    Cell Significance Index: -0.3400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0405
    Cell Significance Index: -0.2700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0485
    Cell Significance Index: -0.6300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0569
    Cell Significance Index: -1.4500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0586
    Cell Significance Index: -0.7300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0700
    Cell Significance Index: -0.9600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0767
    Cell Significance Index: -0.7200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0773
    Cell Significance Index: -0.7900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0803
    Cell Significance Index: -0.7800
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0806
    Cell Significance Index: -0.8500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0810
    Cell Significance Index: -1.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0844
    Cell Significance Index: -2.0500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0867
    Cell Significance Index: -0.9000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0881
    Cell Significance Index: -1.0400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0904
    Cell Significance Index: -1.1900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1043
    Cell Significance Index: -1.1100
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.1044
    Cell Significance Index: -0.5000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1095
    Cell Significance Index: -1.2600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1132
    Cell Significance Index: -0.7000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.1147
    Cell Significance Index: -1.1000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1257
    Cell Significance Index: -1.3300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1276
    Cell Significance Index: -0.9300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1292
    Cell Significance Index: -1.3700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1300
    Cell Significance Index: -1.4400
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.1364
    Cell Significance Index: -1.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1376
    Cell Significance Index: -2.6900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1391
    Cell Significance Index: -1.4700
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.1404
    Cell Significance Index: -1.2500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1479
    Cell Significance Index: -1.4900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1506
    Cell Significance Index: -0.9800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1562
    Cell Significance Index: -1.4500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1572
    Cell Significance Index: -1.4900
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1748
    Cell Significance Index: -1.4900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.1840
    Cell Significance Index: -1.4900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1905
    Cell Significance Index: -1.0200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.2196
    Cell Significance Index: -2.6000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.2251
    Cell Significance Index: -2.5900
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2373
    Cell Significance Index: -2.1700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.2475
    Cell Significance Index: -3.0400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2523
    Cell Significance Index: -2.5600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.2554
    Cell Significance Index: -2.5800
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.2579
    Cell Significance Index: -2.3000
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.2615
    Cell Significance Index: -2.6900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.2705
    Cell Significance Index: -2.7000
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.2750
    Cell Significance Index: -2.2100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2769
    Cell Significance Index: -2.5900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2790
    Cell Significance Index: -2.6000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2901
    Cell Significance Index: -2.4500
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.2932
    Cell Significance Index: -2.4200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2961
    Cell Significance Index: -2.5900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.3497
    Cell Significance Index: -3.0200
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.3542
    Cell Significance Index: -2.7200
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.4179
    Cell Significance Index: -2.7200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.5367
    Cell Significance Index: -2.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-functional gene**: IGLV2 33 is a non-functional gene, meaning it does not produce a functional protein that can bind to antigens. 2. **Immunoglobulin lambda variable gene**: IGLV2 33 belongs to the immunoglobulin lambda variable gene family, which encodes the variable region of the lambda light chain of immunoglobulins. 3. **Significant expression in various cell types**: IGLV2 33 is expressed in goblet cells, neoplastic cells, and intestinal epithelial cells, among others. 4. **Adaptive immune response**: IGLV2 33 is involved in the adaptive immune response, which is a specific and targeted response to pathogens. **Pathways and Functions:** 1. **Adaptive immune response**: IGLV2 33 contributes to the adaptive immune response by regulating the activity of B cells and other immune cells. 2. **Immune regulation**: IGLV2 33 may play a role in regulating the immune response, particularly in the context of tolerance and homeostasis. 3. **Tissue homeostasis**: IGLV2 33 is expressed in intestinal epithelial cells, suggesting that it may contribute to tissue homeostasis and the maintenance of the gut barrier. 4. **Immunoglobulin production**: Although IGLV2 33 is non-functional, it may still influence the production of immunoglobulins by regulating the expression of other genes involved in the immune response. **Clinical Significance:** 1. **Immune-related disorders**: Abnormal expression of IGLV2 33 has been linked to immune-related disorders, such as autoimmune diseases and cancer. 2. **Gastrointestinal diseases**: IGLV2 33 expression in intestinal epithelial cells may contribute to the pathogenesis of gastrointestinal diseases, such as inflammatory bowel disease (IBD). 3. **Cancer**: Non-functional IGLV2 33 may still influence the development and progression of cancer by regulating the immune response and tissue homeostasis. 4. **Immunotherapy**: Understanding the role of IGLV2 33 in the adaptive immune response may provide insights into the development of immunotherapies for cancer and other immune-related disorders. In conclusion, IGLV2 33 is a non-functional gene that plays a crucial role in the adaptive immune response and tissue homeostasis. Its significant expression in various cell types and involvement in immune regulation and disease suggest that it is a key player in the immune system. Further studies are needed to fully elucidate the role of IGLV2 33 in immune-related disorders and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.