Details for: EMX2

Gene ID: 2018

Symbol: EMX2

Ensembl ID: ENSG00000170370

Description: empty spiracles homeobox 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 225.7221
    Cell Significance Index: -35.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.0284
    Cell Significance Index: -35.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.8976
    Cell Significance Index: -30.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.8975
    Cell Significance Index: -35.1100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.8029
    Cell Significance Index: 62.3000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.9982
    Cell Significance Index: 58.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.2743
    Cell Significance Index: 98.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.1855
    Cell Significance Index: 87.6100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 4.0094
    Cell Significance Index: 19.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9937
    Cell Significance Index: -9.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.8660
    Cell Significance Index: 75.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1076
    Cell Significance Index: 604.8900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0920
    Cell Significance Index: 16.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8995
    Cell Significance Index: 28.8100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.8283
    Cell Significance Index: 5.6100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.8117
    Cell Significance Index: 1.8300
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.7892
    Cell Significance Index: 8.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5282
    Cell Significance Index: 72.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3160
    Cell Significance Index: 7.9000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.2412
    Cell Significance Index: 3.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2258
    Cell Significance Index: 42.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1053
    Cell Significance Index: 0.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0906
    Cell Significance Index: 16.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0880
    Cell Significance Index: 38.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0750
    Cell Significance Index: 54.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0514
    Cell Significance Index: 23.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0057
    Cell Significance Index: 5.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0061
    Cell Significance Index: -11.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0192
    Cell Significance Index: -12.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0262
    Cell Significance Index: -1.3600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0398
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0399
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0433
    Cell Significance Index: -32.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0440
    Cell Significance Index: -5.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0563
    Cell Significance Index: -31.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0699
    Cell Significance Index: -8.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0704
    Cell Significance Index: -20.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0948
    Cell Significance Index: -34.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1128
    Cell Significance Index: -16.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1159
    Cell Significance Index: -18.8500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1178
    Cell Significance Index: -2.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1237
    Cell Significance Index: -13.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1307
    Cell Significance Index: -3.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1321
    Cell Significance Index: -9.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1365
    Cell Significance Index: -27.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1509
    Cell Significance Index: -30.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1718
    Cell Significance Index: -29.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1852
    Cell Significance Index: -11.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2001
    Cell Significance Index: -15.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2115
    Cell Significance Index: -12.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2174
    Cell Significance Index: -7.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2179
    Cell Significance Index: -1.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2391
    Cell Significance Index: -30.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2467
    Cell Significance Index: -24.4000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2590
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2620
    Cell Significance Index: -30.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2652
    Cell Significance Index: -7.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2766
    Cell Significance Index: -19.1300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2828
    Cell Significance Index: -8.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2863
    Cell Significance Index: -12.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3040
    Cell Significance Index: -31.6600
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.3085
    Cell Significance Index: -1.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3245
    Cell Significance Index: -8.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3629
    Cell Significance Index: -9.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4011
    Cell Significance Index: -8.3200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.4139
    Cell Significance Index: -3.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4146
    Cell Significance Index: -30.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4477
    Cell Significance Index: -27.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4672
    Cell Significance Index: -5.3100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5032
    Cell Significance Index: -12.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5112
    Cell Significance Index: -39.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5192
    Cell Significance Index: -34.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5460
    Cell Significance Index: -11.8300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5500
    Cell Significance Index: -9.5100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.5650
    Cell Significance Index: -7.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5743
    Cell Significance Index: -26.9900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.6167
    Cell Significance Index: -3.6200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.6571
    Cell Significance Index: -5.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6620
    Cell Significance Index: -18.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.6719
    Cell Significance Index: -10.6600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.6770
    Cell Significance Index: -11.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.6782
    Cell Significance Index: -6.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6835
    Cell Significance Index: -23.7500
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.6837
    Cell Significance Index: -3.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6938
    Cell Significance Index: -43.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6979
    Cell Significance Index: -32.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7000
    Cell Significance Index: -39.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7046
    Cell Significance Index: -7.6600
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.7065
    Cell Significance Index: -10.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7405
    Cell Significance Index: -37.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7522
    Cell Significance Index: -14.6800
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.7899
    Cell Significance Index: -8.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7968
    Cell Significance Index: -22.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8303
    Cell Significance Index: -30.4800
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.8325
    Cell Significance Index: -3.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8435
    Cell Significance Index: -34.5600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.8487
    Cell Significance Index: -6.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8499
    Cell Significance Index: -37.6000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.8663
    Cell Significance Index: -12.0200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.8666
    Cell Significance Index: -7.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EMX2 is a highly conserved gene, with its expression and function conserved across species. It belongs to the homeobox gene family, characterized by the presence of a highly conserved homeodomain. The gene is rapidly transcribed and translated, with a high degree of expression in various tissues. EMX2 is a biallelic gene, meaning that it is expressed in both males and females, and its expression is not restricted to specific cell types or tissues. **Pathways and Functions:** EMX2 is involved in several key developmental pathways, including: 1. **Anterior/Posterior Pattern Specification:** EMX2 plays a critical role in establishing the anterior-posterior axis of the embryo, influencing the development of the central nervous system and other organs. 2. **Brain Development:** EMX2 is essential for the development and regionalization of the cerebral cortex, as well as the differentiation of neurons and glial cells in the brain. 3. **Cell Proliferation in Forebrain:** EMX2 regulates the proliferation of forebrain cells, influencing the formation of the cerebral cortex and the development of the brain. 4. **Central Nervous System Development:** EMX2 is involved in the development of the central nervous system, including the formation of the dentate gyrus and the regulation of neuron migration. 5. **Kidney Development:** EMX2 plays a crucial role in the development of the kidney, influencing the formation of the nephric duct and the differentiation of kidney cells. **Clinical Significance:** The EMX2 gene has been implicated in various human diseases, including: 1. **Neurological Disorders:** Mutations in EMX2 have been associated with neurological disorders, such as autism spectrum disorder, schizophrenia, and epilepsy. 2. **Kidney Disease:** EMX2 has been implicated in the development of kidney disease, including nephrotic syndrome and renal failure. 3. **Cancer:** EMX2 has been shown to be overexpressed in certain types of cancer, including breast cancer and prostate cancer. In conclusion, EMX2 is a crucial gene that plays a pivotal role in various developmental processes, including anterior/posterior pattern specification, brain development, and kidney development. Its significance extends beyond the central nervous system, with expression detected in various tissues. Further research is needed to fully understand the mechanisms by which EMX2 regulates gene expression and to elucidate its role in human disease.

Genular Protein ID: 2009939942

Symbol: EMX2_HUMAN

Name: Homeobox protein EMX2

UniProtKB Accession Codes:

Q04743 G3V305 Q96NN8 Q9BQF4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11549315

Title: Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis and a search for mutations in endometrial cancers.

PubMed ID: 11549315

DOI: 10.1006/geno.2001.6590

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 1352754

Title: Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

PubMed ID: 1352754

DOI: 10.1002/j.1460-2075.1992.tb05319.x

PubMed ID: 8528262

Title: Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly.

PubMed ID: 8528262

DOI: 10.1038/ng0196-94

Sequence Information:

  • Length: 252
  • Mass: 28303
  • Checksum: 90DAEFFC893A971C
  • Sequence:
    • MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAG 
RGVYSNPDLV FAEAVSHPPN PAVPVHPVPP PHALAAHPLP SSHSPHPLFA SQQRDPSTFY 
PWLIHRYRYL GHRFQGNDTS PESFLLHNAL ARKPKRIRTA FSPSQLLRLE HAFEKNHYVV 
GAERKQLAHS LSLTETQVKV WFQNRRTKFK RQKLEEEGSD SQQKKKGTHH INRWRIATKQ 
ASPEEIDVTS DD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.