Gene EMX2 - ENSG00000170370 | NCBI Gene ID: 2018

Details for: EMX2

Gene ID: 2018

Symbol: EMX2

Ensembl ID: ENSG00000170370

Description: empty spiracles homeobox 2

Associated with

Developmental biology
(R-HSA-1266738)
Formation of the nephric duct
(R-HSA-9830364)
Kidney development
(R-HSA-9830369)
Anterior/posterior pattern specification
(GO:0009952)
Axon
(GO:0030424)
Brain development
(GO:0007420)
Cell proliferation in forebrain
(GO:0021846)
Central nervous system development
(GO:0007417)
Cerebral cortex regionalization
(GO:0021796)
Chromatin
(GO:0000785)
Dentate gyrus development
(GO:0021542)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Forebrain cell migration
(GO:0021885)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific double-stranded dna binding
(GO:1990837)
Ureter morphogenesis
(GO:0072197)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: taste receptor cell (CL0000209)
Fold Change: 3.43
Marker Score: 2965
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.05
Marker Score: 3977
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.89
Marker Score: 7283
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.73
Marker Score: 1591
Cell Name: mature astrocyte (CL0002627)
Fold Change: 2.62
Marker Score: 1725
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.4
Marker Score: 6535
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.34
Marker Score: 3310
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.31
Marker Score: 1216
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.27
Marker Score: 22797
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.1
Marker Score: 5158
Cell Name: supporting cell (CL0000630)
Fold Change: 2.01
Marker Score: 3768
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2
Marker Score: 5356
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.99
Marker Score: 7719
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.99
Marker Score: 3297
Cell Name: decidual cell (CL2000002)
Fold Change: 1.98
Marker Score: 8558
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.88
Marker Score: 1992
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.86
Marker Score: 20895
Cell Name: kidney cell (CL1000497)
Fold Change: 1.85
Marker Score: 1238
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.83
Marker Score: 6487
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.75
Marker Score: 1858
Cell Name: epithelial cell (CL0000066)
Fold Change: 1.74
Marker Score: 2760
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.73
Marker Score: 406
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 1.7
Marker Score: 334
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.68
Marker Score: 35815
Cell Name: Unknown (CL0002371)
Fold Change: 1.66
Marker Score: 1765
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1168
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.58
Marker Score: 54576
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.52
Marker Score: 3346
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167925
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.4
Marker Score: 1415
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 869
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 854
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 487
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.14
Marker Score: 2675
Cell Name: goblet cell (CL0000160)
Fold Change: 1.13
Marker Score: 7530.5
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.06
Marker Score: 6864
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 1.06
Marker Score: 482
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251784
Cell Name: radial glial cell (CL0000681)
Fold Change: 1
Marker Score: 370
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71804
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48028
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 462
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.97
Marker Score: 391
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.97
Marker Score: 499
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5316
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.93
Marker Score: 426
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.92
Marker Score: 185
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2742
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327
Cell Name: reticular cell (CL0000432)
Fold Change: 0.9
Marker Score: 329
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.89
Marker Score: 1689
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5282
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.85
Marker Score: 2088
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.83
Marker Score: 635.5
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.79
Marker Score: 1651
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.78
Marker Score: 963
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.78
Marker Score: 841
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1266
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.77
Marker Score: 507
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: B cell (CL0000236)
Fold Change: 0.76
Marker Score: 720
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3113
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 462
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.72
Marker Score: 552
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: keratocyte (CL0002363)
Fold Change: 0.67
Marker Score: 155
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.67
Marker Score: 1356
Cell Name: mast cell (CL0000097)
Fold Change: 0.65
Marker Score: 379
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.62
Marker Score: 160
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.61
Marker Score: 9503
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.58
Marker Score: 311
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 463
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.57
Marker Score: 240
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.55
Marker Score: 528
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175
Cell Name: muscle cell (CL0000187)
Fold Change: 0.54
Marker Score: 154
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.54
Marker Score: 197
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.51
Marker Score: 362
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.51
Marker Score: 267
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.5
Marker Score: 768
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.48
Marker Score: 321
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.46
Marker Score: 106
Cell Name: astrocyte (CL0000127)
Fold Change: 0.45
Marker Score: 393
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.45
Marker Score: 120
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.45
Marker Score: 661
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.43
Marker Score: 280
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.42
Marker Score: 254
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.42
Marker Score: 404.5
Cell Name: germ cell (CL0000586)
Fold Change: 0.41
Marker Score: 717
Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.4
Marker Score: 172
Cell Name: leukocyte (CL0000738)
Fold Change: 0.4
Marker Score: 229
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.39
Marker Score: 247
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.38
Marker Score: 96
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 373
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.37
Marker Score: 175

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**Key characteristics:** * EMX2 is a homeobox gene, a family of transcription factors that are essential for the early stages of CNS development. * It is expressed in a broad range of neural and glial cells throughout the brain. * It is a key regulator of neural tube formation and migration. * It is also involved in the specification of the cerebral cortex and the development of the kidney. **Pathways and functions:** * EMX2 is a key regulator of the AP axis, a developmental process that gives rise to the left and right sides of the brain. * It is required for the migration and survival of neural stem cells in the developing brain. * It is also involved in the differentiation of neural cells into specific types of neurons and glial cells. * EMX2 is also involved in the development of the kidney. * It is a key regulator of the nephric duct, which develops from the neural tube. **Clinical significance:** * Mutations in the EMX2 gene have been linked to several human diseases, including cerebral palsy, schizophrenia, and kidney disorders. * These diseases are characterized by abnormal brain development and function. * Understanding the role of EMX2 in CNS development could lead to the development of new treatments for these diseases. **Additional notes:** * EMX2 is a highly conserved gene, with a similar gene called HOX1 in mice. * It is a multi-exon gene, with multiple protein products. * It is regulated by a complex network of transcription factors, including Nkx2.2 and Sox1.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Homeobox protein EMX2

Genular Protein ID: 2009939942

Symbol: EMX2_HUMAN

Name: Homeobox protein EMX2

UniProtKB Accession Codes:

Q04743 G3V305 Q96NN8 Q9BQF4

Database IDs:

Citations:

PubMed ID: 11549315

Title: Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis and a search for mutations in endometrial cancers.

PubMed ID: 11549315

DOI: 10.1006/geno.2001.6590

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 1352754

Title: Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex.

PubMed ID: 1352754

DOI: 10.1002/j.1460-2075.1992.tb05319.x

PubMed ID: 8528262

Title: Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly.

PubMed ID: 8528262

DOI: 10.1038/ng0196-94

Sequence Information:

Length: 252
Mass: 28303
Checksum: 90DAEFFC893A971C
Sequence:

MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAG 
RGVYSNPDLV FAEAVSHPPN PAVPVHPVPP PHALAAHPLP SSHSPHPLFA SQQRDPSTFY 
PWLIHRYRYL GHRFQGNDTS PESFLLHNAL ARKPKRIRTA FSPSQLLRLE HAFEKNHYVV 
GAERKQLAHS LSLTETQVKV WFQNRRTKFK RQKLEEEGSD SQQKKKGTHH INRWRIATKQ 
ASPEEIDVTS DD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: EMX2

Associated with

Cells (max top 100)

Other Information

Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis and a search for mutations in endometrial cancers. PubMed ID: 11549315

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. PubMed ID: 1352754