Details for: OR10G8

Gene ID: 219869

Symbol: OR10G8

Ensembl ID: ENSG00000234560

Description: olfactory receptor family 10 subfamily G member 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0230
    Cell Significance Index: 0.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0063
    Cell Significance Index: 0.1600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0043
    Cell Significance Index: 0.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0017
    Cell Significance Index: 0.0700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0005
    Cell Significance Index: 0.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0018
    Cell Significance Index: -0.0100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0036
    Cell Significance Index: -0.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0036
    Cell Significance Index: -0.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0040
    Cell Significance Index: -0.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0046
    Cell Significance Index: -0.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0048
    Cell Significance Index: -0.3200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0064
    Cell Significance Index: -0.2100
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0067
    Cell Significance Index: -0.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0072
    Cell Significance Index: -0.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0078
    Cell Significance Index: -0.2000
  • Cell Name: obsolete somatic cell (CL0002371)
    Fold Change: -0.0080
    Cell Significance Index: -0.0600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0089
    Cell Significance Index: -0.1700
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0090
    Cell Significance Index: -0.1000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0097
    Cell Significance Index: -0.1900
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0099
    Cell Significance Index: -0.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0105
    Cell Significance Index: -0.2100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0114
    Cell Significance Index: -0.1400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0114
    Cell Significance Index: -0.1400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0116
    Cell Significance Index: -0.2300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0117
    Cell Significance Index: -0.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0119
    Cell Significance Index: -0.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0125
    Cell Significance Index: -0.2700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0132
    Cell Significance Index: -0.2900
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0132
    Cell Significance Index: -0.1600
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0134
    Cell Significance Index: -0.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0138
    Cell Significance Index: -0.3300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0140
    Cell Significance Index: -0.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0156
    Cell Significance Index: -0.1900
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0157
    Cell Significance Index: -0.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0158
    Cell Significance Index: -0.3300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0164
    Cell Significance Index: -0.2100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0177
    Cell Significance Index: -0.1100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0182
    Cell Significance Index: -0.1100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0183
    Cell Significance Index: -0.1900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0197
    Cell Significance Index: -0.1900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0201
    Cell Significance Index: -0.2300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0203
    Cell Significance Index: -0.1800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0207
    Cell Significance Index: -0.2800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0208
    Cell Significance Index: -0.2200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0217
    Cell Significance Index: -0.2300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0217
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0242
    Cell Significance Index: -0.2300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0262
    Cell Significance Index: -0.3300
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0278
    Cell Significance Index: -0.3000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0296
    Cell Significance Index: -0.2600
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0336
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0347
    Cell Significance Index: -0.2700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0354
    Cell Significance Index: -0.2100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0361
    Cell Significance Index: -0.3300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0362
    Cell Significance Index: -0.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR10G8 is a GPCR that recognizes and binds to odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Expression in Non-Olfactory Tissues:** OR10G8 is expressed in various non-olfactory tissues, including the intestinal epithelium, goblet cells, and pericytes, suggesting a broader functional role beyond olfaction. 3. **G Protein-Coupled Receptor Activity:** OR10G8 is a GPCR that activates G proteins, leading to the activation of downstream signaling pathways. 4. **Sensory Perception Pathways:** OR10G8 is involved in the detection of chemical stimuli involved in sensory perception of smell, as well as in the expression and translocation of olfactory receptors. **Pathways and Functions:** 1. **Olfactory Signaling Pathway:** OR10G8 mediates the binding of odorant molecules to its extracellular ligand-binding pocket, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **G Protein-Coupled Receptor Signaling Pathway:** OR10G8 activates G proteins, leading to the activation of downstream signaling pathways that regulate various cellular processes. 3. **Expression and Translocation of Olfactory Receptors:** OR10G8 is involved in the expression and translocation of olfactory receptors, ensuring proper olfactory function. 4. **Intestinal Epithelial Cell Signaling:** OR10G8 may contribute to the detection of bacterial metabolites and other chemical cues in the intestinal epithelium, influencing gut homeostasis and immune function. **Clinical Significance:** 1. **Olfactory Dysfunction:** Alterations in OR10G8 expression or function may contribute to olfactory dysfunction, such as anosmia or hyposmia, which can have significant impacts on quality of life. 2. **Intestinal Health:** OR10G8 may play a role in the detection of bacterial metabolites and other chemical cues in the intestinal epithelium, influencing gut homeostasis and immune function. Dysregulation of OR10G8 may contribute to intestinal disorders, such as inflammatory bowel disease. 3. **Cancer and Immune Suppression:** OR10G8 has been implicated in the suppression of immune responses in cancer cells, suggesting its potential as a therapeutic target for cancer immunotherapy. 4. **Neurological Disorders:** OR10G8 may also be involved in the pathophysiology of neurological disorders, such as Parkinson's disease and Alzheimer's disease, where olfactory dysfunction is a common feature. In conclusion, OR10G8 is a key player in the detection of chemical stimuli involved in sensory perception of smell, and its expression and function extend beyond olfaction to influence gut health, immune function, and cancer progression. Further research is needed to fully elucidate the role of OR10G8 in human health and disease.

Genular Protein ID: 4239870674

Symbol: O10G8_HUMAN

Name: Olfactory receptor 10G8

UniProtKB Accession Codes:

Q8NGN5 B2RNJ3 Q6IEV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 311
  • Mass: 34519
  • Checksum: 1F3214FD463A7CFD
  • Sequence:
    • MSNASLLTAF ILMGLPHAPA LDAPLFGVFL VVYVLTVLGN LLILLVIRVD SHLHTTMYYF 
LTNLSFIDMW FSTVTVPKLL MTLVFPSGRA ISFHSCMAQL YFFHFLGGTE CFLYRVMSCD 
RYLAISYPLR YTSMMTGRSC TLLATSTWLS GSLHSAVQAI LTFHLPYCGP NWIQHYLCDA 
PPILKLACAD TSAIETVIFV TVGIVASGCF VLIVLSYVSI VCSILRIRTS EGKHRAFQTC 
ASHCIVVLCF FGPGLFIYLR PGSRKAVDGV VAVFYTVLTP LLNPVVYTLR NKEVKKALLK 
LKDKVAHSQS K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.