Details for: SNORD37

Gene ID: 26812

Symbol: SNORD37

Ensembl ID: ENSG00000206775

Description: small nucleolar RNA, C/D box 37

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1276
    Cell Significance Index: 1.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0346
    Cell Significance Index: 0.4700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0200
    Cell Significance Index: 0.2800
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.0067
    Cell Significance Index: 0.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0047
    Cell Significance Index: 0.2200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0035
    Cell Significance Index: -1.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0263
    Cell Significance Index: -1.3700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0375
    Cell Significance Index: -0.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0394
    Cell Significance Index: -1.7900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0738
    Cell Significance Index: -0.8100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0835
    Cell Significance Index: -0.9700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0858
    Cell Significance Index: -1.0200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0874
    Cell Significance Index: -1.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0882
    Cell Significance Index: -2.5400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0949
    Cell Significance Index: -1.2800
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1072
    Cell Significance Index: -1.4800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.1089
    Cell Significance Index: -1.2800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1094
    Cell Significance Index: -0.9100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1101
    Cell Significance Index: -1.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1115
    Cell Significance Index: -2.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1149
    Cell Significance Index: -2.4900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1157
    Cell Significance Index: -1.2600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1180
    Cell Significance Index: -1.3500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1205
    Cell Significance Index: -1.5200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1259
    Cell Significance Index: -1.0200
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1295
    Cell Significance Index: -1.6200
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1296
    Cell Significance Index: -1.4800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1399
    Cell Significance Index: -1.5000
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1414
    Cell Significance Index: -1.5000
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.1456
    Cell Significance Index: -1.0100
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.1507
    Cell Significance Index: -1.5600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1510
    Cell Significance Index: -1.6900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1535
    Cell Significance Index: -1.5400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1601
    Cell Significance Index: -2.0900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1615
    Cell Significance Index: -1.9900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1616
    Cell Significance Index: -2.0800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1670
    Cell Significance Index: -2.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1720
    Cell Significance Index: -2.0300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1961
    Cell Significance Index: -1.9900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1963
    Cell Significance Index: -2.6100
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.2059
    Cell Significance Index: -2.1900
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.2094
    Cell Significance Index: -2.6300
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.2101
    Cell Significance Index: -2.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2138
    Cell Significance Index: -2.5500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2149
    Cell Significance Index: -2.6100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2156
    Cell Significance Index: -2.2000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2363
    Cell Significance Index: -2.2400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.2444
    Cell Significance Index: -2.0600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.2479
    Cell Significance Index: -2.3200
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.2612
    Cell Significance Index: -1.2600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.2658
    Cell Significance Index: -2.5200
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.3183
    Cell Significance Index: -2.6300
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.5353
    Cell Significance Index: -1.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **C/D box motif**: SNORD37 belongs to the C/D box snoRNA family, characterized by the presence of a C/D box motif, which is essential for its binding to the ribosome and other RNA molecules. 2. **Small size**: As a snoRNA, SNORD37 is a small RNA molecule, typically ranging from 50 to 150 nucleotides in length. 3. **Nucleolar localization**: SNORD37 is primarily localized to the nucleolus, where it interacts with ribosomal RNA and other RNA molecules to regulate RNA processing. 4. **Diverse expression patterns**: SNORD37 is expressed in a wide range of cell types, including neuronal receptor cells, smooth muscle myoblasts, and lymphoid lineage-restricted progenitor cells. **Pathways and Functions:** 1. **RNA processing**: SNORD37 plays a crucial role in RNA processing, particularly in the regulation of rRNA and other small RNAs. Its C/D box motif allows it to interact with the ribosome and other RNA molecules, influencing RNA maturation and stability. 2. **Ribosome biogenesis**: SNORD37 is involved in the regulation of ribosome biogenesis, which is essential for protein synthesis and cellular growth. 3. **Cellular differentiation**: SNORD37 may play a role in cellular differentiation, particularly in the development of neuronal receptor cells and smooth muscle myoblasts. 4. **Immune system regulation**: The expression of SNORD37 in lymphoid lineage-restricted progenitor cells and immature innate lymphoid cells suggests its potential involvement in immune system regulation. **Clinical Significance:** 1. **Cancer diagnosis**: Aberrant expression of SNORD37 has been linked to various types of cancer, including leukemia and lymphoma. Its expression levels may serve as a diagnostic biomarker for these diseases. 2. **Neurological disorders**: SNORD37 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. Its expression levels may be altered in these conditions, potentially serving as a biomarker for disease diagnosis and monitoring. 3. **Cardiovascular disease**: The expression of SNORD37 in cardiac endothelial cells and cardiac muscle myoblasts suggests its potential involvement in cardiovascular disease. Further research is needed to elucidate its role in this context. 4. **Immunological disorders**: SNORD37's expression in lymphoid lineage-restricted progenitor cells and immature innate lymphoid cells may have implications for the development of immunological disorders, such as autoimmune diseases. In conclusion, SNORD37 is a small nucleolar RNA with far-reaching implications in RNA processing, cellular differentiation, and immune system regulation. Its expression in diverse cell types and its involvement in various cellular processes make it an attractive candidate for further research in the fields of immunology, cancer biology, and neurology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.