Details for: TRAJ20

Gene ID: 28735

Symbol: TRAJ20

Ensembl ID: ENSG00000211869

Description: T cell receptor alpha joining 20

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 6.2759
    Cell Significance Index: 79.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1359
    Cell Significance Index: 2.9800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0023
    Cell Significance Index: -0.4600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0081
    Cell Significance Index: -0.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0084
    Cell Significance Index: -0.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0119
    Cell Significance Index: -0.4500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0143
    Cell Significance Index: -0.1800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0158
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0193
    Cell Significance Index: -0.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0260
    Cell Significance Index: -0.4800
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0263
    Cell Significance Index: -0.3200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0264
    Cell Significance Index: -0.2500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0278
    Cell Significance Index: -0.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0285
    Cell Significance Index: -0.3400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0323
    Cell Significance Index: -0.4000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0352
    Cell Significance Index: -0.4200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0357
    Cell Significance Index: -0.4100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0360
    Cell Significance Index: -0.4500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0371
    Cell Significance Index: -0.5000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0402
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0422
    Cell Significance Index: -0.3900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0422
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0432
    Cell Significance Index: -0.4200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0440
    Cell Significance Index: -0.5100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0442
    Cell Significance Index: -0.4900
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0443
    Cell Significance Index: -0.5100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0449
    Cell Significance Index: -0.5300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0451
    Cell Significance Index: -0.5900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0452
    Cell Significance Index: -0.5600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0454
    Cell Significance Index: -0.4300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0454
    Cell Significance Index: -0.4900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0468
    Cell Significance Index: -0.5400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0474
    Cell Significance Index: -0.5300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0492
    Cell Significance Index: -0.4600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0506
    Cell Significance Index: -0.5100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0514
    Cell Significance Index: -0.6100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0523
    Cell Significance Index: -0.5600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0525
    Cell Significance Index: -0.5300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0533
    Cell Significance Index: -0.5400
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0541
    Cell Significance Index: -0.6100
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0544
    Cell Significance Index: -0.5300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0560
    Cell Significance Index: -0.4900
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0562
    Cell Significance Index: -0.6100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0585
    Cell Significance Index: -0.3700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0590
    Cell Significance Index: -0.5200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0591
    Cell Significance Index: -0.5100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0655
    Cell Significance Index: -0.5300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0665
    Cell Significance Index: -0.7600
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0681
    Cell Significance Index: -0.5300
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0683
    Cell Significance Index: -0.5900
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0712
    Cell Significance Index: -0.5300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0720
    Cell Significance Index: -0.5000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0807
    Cell Significance Index: -0.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Structure:** The TRAJ20 gene is located on chromosome 11q13.1 and consists of 10 exons, which encode a 230-amino acid protein. 2. **Expression Patterns:** TRAJ20 is expressed in a wide range of immune cells, including innate lymphoid cells, CD4-positive and CD8-positive T cells, B cells, and thymocytes. 3. **Evolutionary Conservation:** TRAJ20 exhibits high sequence similarity to other TCR-associated genes, suggesting its evolutionary conservation and importance in T cell biology. 4. **Regulatory Functions:** TRAJ20 is involved in the regulation of TCR signaling, which is critical for the activation and differentiation of T cells. **Pathways and Functions:** 1. **TCR Signaling:** TRAJ20 is a crucial component of the TCR complex, which is essential for the recognition of antigens by T cells. The TRAJ20 protein interacts with other TCR-associated molecules, such as CD3γ, to regulate TCR signaling. 2. **T Cell Activation:** TRAJ20 plays a critical role in the activation of T cells, which is essential for the initiation of an immune response. The protein is involved in the regulation of T cell receptor-mediated signaling, which leads to the activation of downstream signaling pathways. 3. **T Cell Differentiation:** TRAJ20 is also involved in the regulation of T cell differentiation, which is the process by which T cells acquire specific functions and properties. The protein is required for the proper development of effector T cells, which are essential for the elimination of pathogens and tumor cells. 4. **Immune Homeostasis:** TRAJ20 is also involved in maintaining immune homeostasis, which is the delicate balance between immune activation and tolerance. The protein is required for the regulation of T cell populations, which is essential for preventing excessive immune responses and autoimmune diseases. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of TRAJ20 has been implicated in various autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. The protein's role in T cell activation and differentiation suggests that it may be a therapeutic target for the treatment of these diseases. 2. **Cancer Immunotherapy:** TRAJ20 has been identified as a potential biomarker for cancer immunotherapy. The protein's expression patterns in tumor-infiltrating T cells suggest that it may be involved in the regulation of T cell function and tumor immunity. 3. **Vaccine Development:** TRAJ20 has been identified as a potential target for vaccine development, particularly for the treatment of infectious diseases such as HIV and influenza. The protein's role in T cell activation and differentiation suggests that it may be involved in the regulation of immune responses to vaccine antigens. In conclusion, TRAJ20 is a critical gene that plays a pivotal role in the regulation of T cell receptor signaling, activation, and differentiation. Its broad expression patterns and regulatory functions suggest that it is essential for maintaining immune homeostasis and function. Further research is needed to fully elucidate the role of TRAJ20 in immune biology and to explore its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.