Details for: TRAJ8

Gene ID: 28747

Symbol: TRAJ8

Ensembl ID: ENSG00000211881

Description: T cell receptor alpha joining 8

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 5.6651
    Cell Significance Index: 110.7600
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.8530
    Cell Significance Index: 23.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1833
    Cell Significance Index: 28.6600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2969
    Cell Significance Index: 4.3300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2389
    Cell Significance Index: 3.1400
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.1277
    Cell Significance Index: 1.6700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0446
    Cell Significance Index: 0.7200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0020
    Cell Significance Index: -0.4100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0060
    Cell Significance Index: -0.0700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0080
    Cell Significance Index: -0.1800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0087
    Cell Significance Index: -0.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0153
    Cell Significance Index: -0.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0203
    Cell Significance Index: -0.3500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0271
    Cell Significance Index: -0.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0277
    Cell Significance Index: -0.3300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0281
    Cell Significance Index: -0.3800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0288
    Cell Significance Index: -0.3400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0296
    Cell Significance Index: -0.3800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0331
    Cell Significance Index: -0.3900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0393
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0396
    Cell Significance Index: -0.3700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0410
    Cell Significance Index: -0.3900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0446
    Cell Significance Index: -0.4100
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0463
    Cell Significance Index: -0.4800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0466
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0477
    Cell Significance Index: -0.4800
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0478
    Cell Significance Index: -0.5100
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0494
    Cell Significance Index: -0.4900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0495
    Cell Significance Index: -0.5400
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0502
    Cell Significance Index: -0.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0540
    Cell Significance Index: -0.5200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0570
    Cell Significance Index: -0.5400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0667
    Cell Significance Index: -0.5000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0710
    Cell Significance Index: -0.5500
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0875
    Cell Significance Index: -0.5800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0888
    Cell Significance Index: -1.0300
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1460
    Cell Significance Index: -1.2600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.2308
    Cell Significance Index: -2.6000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.2955
    Cell Significance Index: -3.1300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.2970
    Cell Significance Index: -3.0100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.3414
    Cell Significance Index: -3.4400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3415
    Cell Significance Index: -3.4500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.4790
    Cell Significance Index: -3.8800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.6180
    Cell Significance Index: -3.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** TRAJ8 is significantly expressed in CD4+ and CD8+ T cells, as well as in innate lymphoid cells, naive thymus-derived CD4+ T cells, and mature NK T cells. This widespread expression suggests that TRAJ8 plays a critical role in the development and function of various T cell subsets. 2. **Gene Structure:** The TRAJ8 gene is located on chromosome 11q24.1 and consists of 10 exons. The gene's structure is characterized by a unique exon-intron arrangement, which may contribute to its regulatory functions. 3. **Evolutionary Conservation:** TRAJ8 is highly conserved across species, suggesting that it has evolved to play a fundamental role in T cell development and function. **Pathways and Functions:** 1. **T Cell Receptor (TCR) Maturation:** TRAJ8 is involved in the maturation of the TCR, a complex of proteins that recognizes and binds to specific antigens. The TRAJ8 gene product interacts with other TCR components to regulate the assembly and stability of the TCR complex. 2. **T Cell Development:** TRAJ8 is essential for the development and maturation of T cells in the thymus. The gene product helps to regulate the selection of T cells that are tolerant to self-antigens and can recognize foreign antigens. 3. **T Cell Activation:** TRAJ8 is also involved in the activation of T cells in response to antigen presentation. The gene product interacts with other signaling molecules to regulate the activation of T cells and the production of cytokines. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of TRAJ8 has been implicated in several autoimmune diseases, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Alterations in TRAJ8 expression or function may contribute to the development of these diseases. 2. **Cancer:** TRAJ8 has been identified as a potential oncogene in certain types of cancer, including T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoma. Overexpression of TRAJ8 may contribute to the development and progression of these cancers. 3. **Immunodeficiency Disorders:** TRAJ8 is also essential for the function of innate lymphoid cells, which are critical for the innate immune response. Dysregulation of TRAJ8 may contribute to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, TRAJ8 is a crucial gene that plays a significant role in the development and function of T cells. Its dysregulation has been implicated in several immune-related disorders, including autoimmune diseases, cancer, and immunodeficiency disorders. Further research is needed to fully understand the mechanisms by which TRAJ8 regulates T cell development and function, and to explore its potential as a therapeutic target for the treatment of these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.