Details for: OR5AP2

Gene ID: 338675

Symbol: OR5AP2

Ensembl ID: ENSG00000172464

Description: olfactory receptor family 5 subfamily AP member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.5733
    Cell Significance Index: 25.4800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.1943
    Cell Significance Index: 30.4300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.2773
    Cell Significance Index: 3.5900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.1918
    Cell Significance Index: 2.0400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1068
    Cell Significance Index: 1.8300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.1008
    Cell Significance Index: 1.3800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0757
    Cell Significance Index: 1.0400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0317
    Cell Significance Index: 0.1900
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0212
    Cell Significance Index: 0.2200
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.0115
    Cell Significance Index: 0.0800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0079
    Cell Significance Index: 0.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0074
    Cell Significance Index: -0.1000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0124
    Cell Significance Index: -0.1100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0165
    Cell Significance Index: -0.1700
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0181
    Cell Significance Index: -0.2100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0187
    Cell Significance Index: -0.1200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0327
    Cell Significance Index: -0.3500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0371
    Cell Significance Index: -0.5400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0401
    Cell Significance Index: -0.3800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0412
    Cell Significance Index: -0.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0446
    Cell Significance Index: -2.3200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0451
    Cell Significance Index: -0.5400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0458
    Cell Significance Index: -0.6000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0839
    Cell Significance Index: -0.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0867
    Cell Significance Index: -2.1000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0965
    Cell Significance Index: -0.8200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1002
    Cell Significance Index: -1.9600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.1365
    Cell Significance Index: -1.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1473
    Cell Significance Index: -2.9400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1521
    Cell Significance Index: -1.8700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1807
    Cell Significance Index: -2.4400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2005
    Cell Significance Index: -2.5300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.2023
    Cell Significance Index: -2.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2033
    Cell Significance Index: -2.9100
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.2094
    Cell Significance Index: -1.8300
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.2127
    Cell Significance Index: -2.4700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2300
    Cell Significance Index: -2.7100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2345
    Cell Significance Index: -2.7600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2397
    Cell Significance Index: -2.5700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2409
    Cell Significance Index: -3.2100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2797
    Cell Significance Index: -2.9700
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2816
    Cell Significance Index: -2.3300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2940
    Cell Significance Index: -3.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3269
    Cell Significance Index: -5.5100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.3624
    Cell Significance Index: -4.1400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3644
    Cell Significance Index: -4.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3896
    Cell Significance Index: -4.2500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.7375
    Cell Significance Index: -5.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Function:** OR5AP2 is a member of the olfactory receptor family, which is responsible for detecting odorant molecules in the air. The gene encodes a G protein-coupled receptor that interacts with odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **Broad Tissue Expression:** OR5AP2 is expressed in various cell types, including renal beta-intercalated cells, erythrocytes, ciliated epithelial cells, and neuronal receptor cells, suggesting its involvement in multiple physiological processes. 3. **G Protein-Coupled Receptor Activity:** OR5AP2 exhibits G protein-coupled receptor activity, which enables it to interact with G proteins and modulate downstream signaling pathways. 4. **Sensory Perception:** OR5AP2 is involved in the sensory perception of smell, which is essential for detecting and responding to chemical stimuli in the environment. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR5AP2 detects odorant molecules, triggering a signaling cascade that ultimately leads to the perception of smell. 2. **G Protein-Coupled Receptor Signaling:** OR5AP2 interacts with G proteins, modulating downstream signaling pathways that regulate various cellular processes. 3. **Olfactory Receptor Activity:** OR5AP2 exhibits olfactory receptor activity, enabling it to interact with odorant molecules and trigger the perception of smell. 4. **Sensory Perception of Smell:** OR5AP2 is involved in the sensory perception of smell, which is essential for detecting and responding to chemical stimuli in the environment. **Clinical Significance:** 1. **Olfactory Disorders:** OR5AP2 has been implicated in various olfactory disorders, including anosmia (loss of smell) and hyposmia (reduced sense of smell). Dysregulation of OR5AP2 may contribute to the development of these disorders. 2. **Therapeutic Targeting:** OR5AP2 may serve as a therapeutic target for the diagnosis and treatment of olfactory disorders. Inhibitors or agonists of OR5AP2 could potentially modulate olfactory receptor activity, improving olfactory function. 3. **Hematopoietic System:** OR5AP2 is expressed in megakaryocyte-erythroid progenitor cells, suggesting its involvement in hematopoiesis. Further studies may reveal the role of OR5AP2 in the development and function of the hematopoietic system. 4. **Gastrointestinal System:** OR5AP2 is expressed in goblet cells, suggesting its involvement in the gastrointestinal system. OR5AP2 may play a role in regulating gut motility, secretion, or immune responses. In conclusion, OR5AP2 is a critical component of the olfactory system, involved in the detection of chemical stimuli and sensory perception of smell. Its expression in various cell types and involvement in G protein-coupled receptor activity underscore its significance in modulating sensory responses. Further research is needed to fully elucidate the functions and clinical significance of OR5AP2, but its potential as a therapeutic target for olfactory disorders makes it an exciting area of investigation.

Genular Protein ID: 1643748667

Symbol: O5AP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8NGF4 B2RNM8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 3 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 316
  • Mass: 35508
  • Checksum: 5C2A3D9B7482400C
  • Sequence:
    • MRLMKEVRGR NQTEVTEFLL LGLSDNPDLQ GVLFALFLLI YMANMVGNLG MIVLIKIDLC 
LHTPMYFFLS SLSFVDASYS SSVTPKMLVN LMAENKAISF HGCAAQFYFF GSFLGTECFL 
LAMMAYDRYA AIWNPLLYPV LVSGRICFLL IATSFLAGCG NAAIHTGMTF RLSFCGSNRI 
NHFYCDTPPL LKLSCSDTHF NGIVIMAFSS FIVISCVMIV LISYLCIFIA VLKMPSLEGR 
HKAFSTCASY LMAVTIFFGT ILFMYLRPTS SYSMEQDKVV SVFYTVIIPV LNPLIYSLKN 
KDVKKALKKI LWKHIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.