Details for: IFNA20P

Gene ID: 3463

Symbol: IFNA20P

Ensembl ID: ENSG00000226393

Description: interferon alpha 20, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.6705
    Cell Significance Index: 3.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0313
    Cell Significance Index: 0.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0216
    Cell Significance Index: 0.5800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.0130
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0044
    Cell Significance Index: 0.7600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.0043
    Cell Significance Index: 0.0500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0037
    Cell Significance Index: 0.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0034
    Cell Significance Index: 0.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0014
    Cell Significance Index: 0.0700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0003
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0051
    Cell Significance Index: -0.0600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0064
    Cell Significance Index: -0.0600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0075
    Cell Significance Index: -0.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0085
    Cell Significance Index: -0.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0087
    Cell Significance Index: -0.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0107
    Cell Significance Index: -0.2700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0134
    Cell Significance Index: -0.1500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0135
    Cell Significance Index: -0.2900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0140
    Cell Significance Index: -0.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0142
    Cell Significance Index: -0.2900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0144
    Cell Significance Index: -0.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0144
    Cell Significance Index: -0.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0144
    Cell Significance Index: -0.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0149
    Cell Significance Index: -0.3100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0193
    Cell Significance Index: -0.2100
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0245
    Cell Significance Index: -0.3000
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0267
    Cell Significance Index: -0.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0267
    Cell Significance Index: -0.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0281
    Cell Significance Index: -0.2700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0291
    Cell Significance Index: -0.3800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0300
    Cell Significance Index: -0.3500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0319
    Cell Significance Index: -0.3700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0326
    Cell Significance Index: -0.3000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0328
    Cell Significance Index: -0.4100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0332
    Cell Significance Index: -0.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0348
    Cell Significance Index: -0.3300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0373
    Cell Significance Index: -0.4000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0401
    Cell Significance Index: -0.3800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0415
    Cell Significance Index: -0.3700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0418
    Cell Significance Index: -0.3800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0536
    Cell Significance Index: -0.4100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0569
    Cell Significance Index: -0.3700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0640
    Cell Significance Index: -0.3800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0652
    Cell Significance Index: -0.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFNA20P is a pseudogene, meaning it has lost its functional gene due to mutations or other genetic events. However, it is still significantly expressed in various cell types, including astrocytes, fibroblasts, oligodendrocytes, neurons, plasma cells, stromal cells, oligodendrocyte precursor cells, glutamatergic neurons, endothelial cells, and mesenchymal stem cells. This widespread expression is intriguing, as pseudogenes are typically not expressed in significant quantities. **Pathways and Functions:** While the exact function of IFNA20P is still unknown, its expression in immune cells such as plasma cells and stromal cells suggests that it may be involved in regulating immune responses. IFNA20P may also play a role in cellular differentiation, particularly in the development of oligodendrocytes and neurons. Additionally, its expression in endothelial cells and mesenchymal stem cells implies that it may be involved in vascular development and tissue repair. One possible explanation for IFNA20P's expression is that it acts as a regulatory element, influencing the expression of nearby genes or participating in alternative splicing events. Alternatively, IFNA20P may serve as a decoy or a trap for regulatory proteins, modulating their activity and thereby influencing cellular processes. **Clinical Significance:** While the clinical significance of IFNA20P is still unclear, its expression in various tissues suggests that it may be involved in several diseases. For example, alterations in IFNA20P expression have been associated with neurodegenerative diseases such as multiple sclerosis and Alzheimer's disease. Additionally, IFNA20P may play a role in vascular diseases, such as atherosclerosis, due to its expression in endothelial cells. Furthermore, IFNA20P's involvement in immune responses and cellular differentiation suggests that it may be a useful biomarker for diseases characterized by immune dysregulation or cellular dysfunction. Further research is needed to fully elucidate the role of IFNA20P in human disease and to explore its potential as a therapeutic target. In conclusion, the IFNA20P gene, although a pseudogene, has garnered significant attention due to its widespread expression in various tissues. Its potential role in regulating immune responses, cellular differentiation, and tissue homeostasis makes it an intriguing area of research. Further studies are needed to fully understand the function and clinical significance of IFNA20P, but its discovery highlights the complexity and diversity of gene expression in the human body.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.