Details for: SLC2A11

Gene ID: 66035

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SLC2A11

Ensembl ID: ENSG00000133460

Description: solute carrier family 2 member 11

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • choroid plexus epithelial cell CL0000706
    CSI 8.02
    rCSI 13.13%
    PRS 83.95
  • GABAergic neuron CL0000617
    CSI 6.18
    rCSI 20.72%
    PRS 77.67
  • retinal cone cell CL0000573
    CSI 5.91
    rCSI 9.51%
    PRS 83.19
  • epithelial cell of lung CL0000082
    CSI 3.57
    rCSI 2.96%
    PRS 91.61
  • retinal rod cell CL0000604
    CSI 3.44
    rCSI 6.07%
    PRS 86.83
  • cardiac muscle cell CL0000746
    CSI 3.42
    rCSI 4.91%
    PRS 83.1
  • precursor B cell CL0000817
    CSI 3.32
    rCSI 2.91%
    PRS 94.28
  • plasmablast CL0000980
    CSI 3.18
    rCSI 2.5%
    PRS 92.9
  • rod bipolar cell CL0000751
    CSI 3.18
    rCSI 5.71%
    PRS 85.97
  • ON-bipolar cell CL0000749
    CSI 3.1
    rCSI 4.6%
    PRS 89.73
  • immature B cell CL0000816
    CSI 2.96
    rCSI 2.2%
    PRS 95.97
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.92
    rCSI 2.04%
    PRS 93.6
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.71
    rCSI 3.85%
    PRS 88.65
  • group 3 innate lymphoid cell CL0001071
    CSI 2.61
    rCSI 1.96%
    PRS 93.84
  • epithelial cell of proximal tubule CL0002306
    CSI 2.55
    rCSI 6.23%
    PRS 84.33
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.51
    rCSI 3%
    PRS 78.12
  • extravillous trophoblast CL0008036
    CSI 2.51
    rCSI 3.1%
    PRS 89.2
  • retinal bipolar neuron CL0000748
    CSI 2.45
    rCSI 4.58%
    PRS 82.63
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.4
    rCSI 2.98%
    PRS 75.93
  • mature B cell CL0000785
    CSI 2.16
    rCSI 1.88%
    PRS 95.93
  • sncg GABAergic cortical interneuron CL4023015
    CSI 2.13
    rCSI 3.43%
    PRS 79.04
  • retina horizontal cell CL0000745
    CSI 2.12
    rCSI 3.23%
    PRS 87.71
  • L6b glutamatergic cortical neuron CL4023038
    CSI 1.99
    rCSI 6.22%
    PRS 79.42
  • parietal epithelial cell CL1000452
    CSI 1.82
    rCSI 4.88%
    PRS 85.6
  • peripheral nervous system neuron CL2000032
    CSI 1.79
    rCSI 2.44%
    PRS 84.66
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.76
    rCSI 4.47%
    PRS 84.72
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.75
    rCSI 6.31%
    PRS 76.09
  • IgG plasma cell CL0000985
    CSI 1.74
    rCSI 2.08%
    PRS 94.28
  • astrocyte of the cerebral cortex CL0002605
    CSI 1.69
    rCSI 3.78%
    PRS 78.57
  • S cone cell CL0003050
    CSI 1.57
    rCSI 6.91%
    PRS 86.18
  • basket cell CL0000118
    CSI 1.5
    rCSI 9.42%
    PRS 71.39
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.45
    rCSI 2.57%
    PRS 77.5
  • smooth muscle cell CL0000192
    CSI 1.43
    rCSI 3.42%
    PRS 84.96
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.33
    rCSI 4.16%
    PRS 81.07
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.31
    rCSI 3.18%
    PRS 75.88
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.26
    rCSI 4.77%
    PRS 78.3
  • amacrine cell CL0000561
    CSI 1.07
    rCSI 3.1%
    PRS 82.56
  • dopaminergic neuron CL0000700
    CSI 1.04
    rCSI 5.89%
    PRS 80.32
  • serotonergic neuron CL0000850
    CSI 1.03
    rCSI 4.62%
    PRS 76.78
  • retinal ganglion cell CL0000740
    CSI 1
    rCSI 2.21%
    PRS 80.49
  • direct pathway medium spiny neuron CL4023026
    CSI 0.99
    rCSI 23.65%
    PRS 75.87
  • eye photoreceptor cell CL0000287
    CSI 0.89
    rCSI 10.03%
    PRS 92.86
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.89
    rCSI 21.38%
    PRS 76.02
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.77
    rCSI 4.56%
    PRS 78.53
  • ON midget ganglion cell CL4033046
    CSI 0.27
    rCSI 5.55%
    PRS 82.39

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SLC2A11](/details-gene/66035), or Solute Carrier Family 2 Member 11, is a protein-coding gene located on chromosome 22q11.23. It functions as a facilitative hexose transporter with a notable capacity for transporting both glucose and fructose across the plasma membrane. Its expression is particularly significant in a diverse range of metabolically active and specialized cell types. **Overall**, its most prominent expression is observed in [choroid plexus epithelial cell](/details-cell/CL0000706), [GABAergic neuron](/details-cell/CL0000617), and various retinal cells, including [retinal cone cell](/details-cell/CL0000573), suggesting a crucial role in nutrient supply and energy homeostasis within the central nervous system and the eye. ## Cellular Roles and Expression Landscape The expression profile of [SLC2A11](/details-gene/66035) indicates its importance in tissues with high energy demands or specialized transport functions. **Overall**, the gene shows the highest significance in cells of the central nervous system and sensory organs, including [choroid plexus epithelial cell](/details-cell/CL0000706) (CSI: 8.02), [GABAergic neuron](/details-cell/CL0000617) (CSI: 6.18), [retinal cone cell](/details-cell/CL0000573) (CSI: 5.91), and [retinal rod cell](/details-cell/CL0000604) (CSI: 3.44). This pattern suggests a vital role in fueling neuronal activity and maintaining the unique metabolic environment of the brain and retina. Beyond the nervous system, [SLC2A11](/details-gene/66035) is also significantly expressed in other metabolically demanding or transport-oriented cells. These include [cardiac muscle cell](/details-cell/CL0000746) (CSI: 3.42), highlighting a potential role in cardiac energy metabolism, as well as various epithelial cells involved in secretion and reabsorption, such as [epithelial cell of lung](/details-cell/CL0000082) (CSI: 3.57) and [epithelial cell of proximal tubule](/details-cell/CL0002306) in the kidney (CSI: 2.55). Furthermore, a distinct expression signature is evident within the immune system, particularly in the B-cell lineage, with significant expression in [precursor B cell](/details-cell/CL0000817) (CSI: 3.32), [immature B cell](/details-cell/CL0000816) (CSI: 2.96), and the highly active [plasmablast](/details-cell/CL0000980) (CSI: 3.18). This suggests that [SLC2A11](/details-gene/66035) may be involved in supplying the necessary energy for B-cell development, maturation, and antibody production. ## Pathways and Molecular Function The function of [SLC2A11](/details-gene/66035) is well-defined by its involvement in monosaccharide transport. Functional annotation reveals its participation in biological processes such as [D-glucose transmembrane transport](/details-go/GO:1904659), [fructose transmembrane transport](/details-go/GO:0015755), and more broadly, [hexose transmembrane transport](/details-go/GO:0008645). Its molecular functions are classified as [D-glucose transmembrane transporter activity](/details-go/GO:0055056) and [fructose transmembrane transporter activity](/details-go/GO:0005353). These activities were first described in studies that cloned and characterized the transporter, identifying it as a novel member of the facilitative glucose transporter family ([Link](https://doi.org/10.1006/bbrc.2001.6101), [Link](https://doi.org/10.1016/s1096-7192(02)00018-5)). Consistent with its role as a transmembrane protein, [SLC2A11](/details-gene/66035) is localized to the [plasma membrane](/details-go/GO:0005886). Its activity contributes to major metabolic pathways, as reflected by its inclusion in Reactome pathways such as [Cellular hexose transport](/details-reactome/R-HSA-189200) and [Slc-mediated transmembrane transport](/details-reactome/R-HSA-425407). This functional profile aligns perfectly with its high expression in cells requiring a constant and substantial supply of sugar for energy production, such as neurons and muscle cells. ## Research Directions The specific and diverse expression pattern of [SLC2A11](/details-gene/66035) points to several testable hypotheses regarding its physiological and pathological roles. 1. **Hypothesis 1: Role in Neuro-sensory Homeostasis:** The prominent expression of [SLC2A11](/details-gene/66035) in the choroid plexus, neurons, and retinal cells suggests it is critical for maintaining glucose and fructose homeostasis in the central nervous system and eye. Its dysfunction could lead to impaired cerebrospinal fluid composition, reduced neuronal energy supply, or photoreceptor degeneration, potentially contributing to metabolic neuropathies or retinopathies. 2. **Hypothesis 2: Involvement in Humoral Immunity:** The consistent expression of [SLC2A11](/details-gene/66035) across the B-cell developmental lineage, peaking in metabolically active [plasmablast](/details-cell/CL0000980) cells, implies a specialized role in fueling B-cell activation, proliferation, and antibody synthesis. Loss of [SLC2A11](/details-gene/66035) function may compromise the humoral immune response, leading to immunodeficiency. 3. **Hypothesis 3: Contribution to Cardiac Metabolism:** The high expression in [cardiac muscle cell](/details-cell/CL0000746) suggests that [SLC2A11](/details-gene/66035) is an important contributor to cardiac energy substrate uptake. Under conditions of metabolic stress, such as ischemia or heart failure, alterations in [SLC2A11](/details-gene/66035) expression or activity could impact the heart's ability to adapt its fuel utilization, potentially exacerbating cardiac dysfunction. * **Proposed Experimental Approach:** To test the role of [SLC2A11](/details-gene/66035) in B-cell function (Hypothesis 2), a conditional knockout mouse model could be established by crossing a floxed *Slc2a11* mouse with a CD19-Cre driver, ensuring B-cell-specific deletion. Following immunization with a T-cell dependent antigen, key aspects of the humoral response, including germinal center formation (via histology and flow cytometry), antigen-specific antibody titers (via ELISA), and the generation of memory B cells and plasma cells, would be compared between knockout and wild-type mice. In parallel, metabolic analyses (e.g., Seahorse flux analysis) on B cells isolated from these mice and activated in vitro would directly assess the impact of [SLC2A11](/details-gene/66035) deletion on glucose uptake and glycolysis. * **Therapeutic Potential:** As a solute carrier, [SLC2A11](/details-gene/66035) is a potentially druggable target. However, its widespread expression in critical tissues like the brain, retina, and heart suggests that systemic inhibition could lead to severe off-target toxicity. A more viable strategy would be to target [SLC2A11](/details-gene/66035) in pathologies where specific cell types become pathologically dependent on it, such as in B-cell malignancies (e.g., lymphomas, multiple myeloma) that exhibit high metabolic rates. In this context, targeted inhibition of [SLC2A11](/details-gene/66035) could represent a therapeutic approach to selectively starve and eliminate cancerous B-lineage cells.

Genular Protein ID: 3967360103

Symbol: GTR11_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BYW1 E9PH55 Q542Y4 Q6ICJ5 Q8WXF9 Q8WYM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 10 Ensembl 6 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11741323

Title: Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants.

PubMed ID: 11741323

DOI: 10.1006/bbrc.2001.6101

PubMed ID: 12175779

Title: Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues.

PubMed ID: 12175779

DOI: 10.1016/s1096-7192(02)00018-5

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 496
  • Mass: 53703
  • Checksum: 55FFEA82C7007D6D
  • Sequence:
    • MRALRRLIQG RILLLTICAA GIGGTFQFGY NLSIINAPTL HIQEFTNETW QARTGEPLPD 
HLVLLMWSLI VSLYPLGGLF GALLAGPLAI TLGRKKSLLV NNIFVVSAAI LFGFSRKAGS 
FEMIMLGRLL VGVNAGVSMN IQPMYLGESA PKELRGAVAM SSAIFTALGI VMGQVVGLRE 
LLGGPQAWPL LLASCLVPGA LQLASLPLLP ESPRYLLIDC GDTEACLAAL RRLRGSGDLA 
GELEELEEER AACQGCRARR PWELFQHRAL RRQVTSLVVL GSAMELCGND SVYAYASSVF 
RKAGVPEAKI QYAIIGTGSC ELLTAVVSCV VIERVGRRVL LIGGYSLMTC WGSIFTVALC 
LQSSFPWTLY LAMACIFAFI LSFGIGPAGV TGILATELFD QMARPAACMV CGALMWIMLI 
LVGLGFPFIM EALSHFLYVP FLGVCVCGAI YTGLFLPETK GKTFQEISKE LHRLNFPRRA 
QGPTWRSLEV IQSTEL

Genular Protein ID: 1040753419

Symbol: A0A087X018_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X018

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18477386

Title: Finishing the finished human chromosome 22 sequence.

PubMed ID: 18477386

DOI: 10.1186/gb-2008-9-5-r78

Sequence Information:

  • Length: 535
  • Mass: 57142
  • Checksum: 15941F837FE9F9FE
  • Sequence:
    • MEDELEPSLR PRTQIQGRIL LLTICAAGIG GTFQFGYNLS IINAPTLHIQ EFTNETWQAR 
TGEPLPDHLV LLMWSLIVSL YPLGGLFGAL LAGPLAITLG RKKSLLVNNI FVVSAAILFG 
FSRKAGSFEM IMLGRLLVGV NAGVSMNIQP MYLGESAPKE LRGAVAMSSA IFTALGIVMG 
QVVGLRELLG GPQAWPLLLA SCLVPGALQL ASLPLLPESP RYLLIDCGDT EACLAALRRL 
RGSGDLAGEL EELEEERAAC QGCRARRPWE LFQHRALRRQ VTSLVVLGSA MELCGNDSVY 
AYASSVFRKA GVPEAKIQYA IIGTGSCELL TAVVSVAGVD EGWGVQAGLT STSPPPRPRQ 
SSFPWTLYLA MACIFAFILS FGIGPAGVTG ILATELFDQM ARPAACMVCG ALMWIMLILV 
GLGFPFIMVL GSFLIRRRPC PTSSMSLSLV SVSVGPSTLA CSFLRPKARP SKRSPRNYTD 
STSPGGPRAP RGGAWRLSSQ QNSSPKGVAR AKASYCPVLC FLPGPWSSLP PAFLI

Genular Protein ID: 2948385382

Symbol: B7Z6F0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6F0

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 463
  • Mass: 49614
  • Checksum: C537236FE3BADFB8
  • Sequence:
    • MEDELEPSLR PRTQIQGRIL LLTICAAGIG GTFQFGYNLS IINAPTLHIQ EFTNETWQAR 
TGEPLPDHLV LLMWSLIVSL YPLGGLFGAL LAGPLAMTLG RKKSLLVNNI FVVSAAILFG 
FSRKAGSFEM IMLGRLLVGV NAGVSMNIQP MYLGESAPKE LRGAVAMSSA IFTALGIVMG 
QVVGLRELLG GPQAWPLLLA SCLVPGALQL ASLPLLPESP RYLLIDCGDT EACLAALRRL 
RGSGDLAGEL EELEEERAAC QGCRARRPWE LFQHRALRRQ VTSLVVLGSA MELCGNDSVY 
AYASSVFRKA GVPEAKIQYA IIGTGSCELL TAVVSVAGVD EGWGVQAGLT STSPPPRPRQ 
SSFPWTLYLA MACIFAFILS FGIGPAGVTG ILATELFDQM ARPAACMVCG ALMWIMLILV 
GLGFPFIMVL GSFLIAGGLV PLPLCPFPWC LCLWGHLHWP VPS

Genular Protein ID: 3914382198

Symbol: Q6PJ99_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PJ99

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 Pfam 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 104
  • Mass: 11507
  • Checksum: 9CA82755CB9CCF26
  • Sequence:
    • GVLGEQRGGQ MPPHDLSWAF CLGVDGDTPG LGVFFNPQEA LSHFLYVPFL GVCVCGAIYT 
GLFLPETKGK TFQEISKELH RLNFPRRAQG PTWRSLEVIQ STEL