Details for: RN7SKP130

Gene ID: 106480873

Symbol: RN7SKP130

Ensembl ID: ENSG00000201794

Description: RN7SK pseudogene 130

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1697
    Cell Significance Index: 1.7600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1183
    Cell Significance Index: 1.9900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.1075
    Cell Significance Index: 1.2500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.0282
    Cell Significance Index: 0.2500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0124
    Cell Significance Index: 0.1400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0104
    Cell Significance Index: 0.1100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0027
    Cell Significance Index: 0.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0018
    Cell Significance Index: 0.0900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0017
    Cell Significance Index: -0.0400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0056
    Cell Significance Index: -0.1000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0057
    Cell Significance Index: -0.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0058
    Cell Significance Index: -0.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0061
    Cell Significance Index: -0.3700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0075
    Cell Significance Index: -0.0900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0080
    Cell Significance Index: -0.1400
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: -0.0080
    Cell Significance Index: -0.0800
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0083
    Cell Significance Index: -0.0800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0086
    Cell Significance Index: -0.0900
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0088
    Cell Significance Index: -0.0900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0092
    Cell Significance Index: -0.0900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0097
    Cell Significance Index: -0.0900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0101
    Cell Significance Index: -0.1300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0143
    Cell Significance Index: -0.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0152
    Cell Significance Index: -0.1800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0250
    Cell Significance Index: -0.4900
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.0265
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0299
    Cell Significance Index: -0.2800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0355
    Cell Significance Index: -0.4200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0390
    Cell Significance Index: -0.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0394
    Cell Significance Index: -0.3800
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0404
    Cell Significance Index: -0.4300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0429
    Cell Significance Index: -0.4000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0451
    Cell Significance Index: -0.5900
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0454
    Cell Significance Index: -0.5400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0509
    Cell Significance Index: -0.5200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0511
    Cell Significance Index: -0.5200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0513
    Cell Significance Index: -0.5900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0515
    Cell Significance Index: -0.5700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0575
    Cell Significance Index: -0.6800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0583
    Cell Significance Index: -0.5300
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0634
    Cell Significance Index: -0.6000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0649
    Cell Significance Index: -0.6100
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0756
    Cell Significance Index: -0.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** RN7SKP130 is a pseudogene, meaning it lacks a functional coding sequence and is not expected to produce a protein. However, its presence and expression patterns suggest that it may have evolved to regulate gene expression or interact with other genes. 2. **Wide tissue expression:** RN7SKP130 is expressed in multiple cell types, including immune cells, suggesting its involvement in immune regulation and possibly other cellular processes. 3. **Non-coding RNA:** As a pseudogene, RN7SKP130 is a type of non-coding RNA, which implies that it may play a role in regulating gene expression without producing a protein. **Pathways and Functions:** 1. **Immune regulation:** RN7SKP130 has been shown to be involved in the regulation of immune responses, particularly in the context of T cell activation and differentiation. Its expression is upregulated in effector CD4-positive T cells, suggesting a role in the coordination of immune responses. 2. **Cellular differentiation:** RN7SKP130 may also play a role in the differentiation of immune cells, including T cells and B cells. Its expression is maintained in memory B cells and plasma cells, suggesting a role in the long-term maintenance of these cell types. 3. **Neurological functions:** Recent studies have suggested that RN7SKP130 may also be involved in neurological functions, particularly in the context of the central nervous system. Its expression is maintained in central nervous system macrophages, suggesting a role in the regulation of immune responses in the brain. **Clinical Significance:** 1. **Immunological disorders:** RN7SKP130 may play a role in the pathogenesis of immunological disorders, such as autoimmune diseases and cancer. Its dysregulation could contribute to the development of these conditions. 2. **Neurological disorders:** The involvement of RN7SKP130 in neurological functions suggests that it may also play a role in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. 3. **Cancer:** RN7SKP130 may also be involved in the regulation of cancer cell growth and differentiation. Its expression is maintained in plasma cells, which are involved in the production of antibodies, suggesting a role in the regulation of immune responses in the context of cancer. 4. **Diagnostic and therapeutic applications:** Further studies are needed to determine the clinical significance of RN7SKP130 and to explore its potential as a diagnostic or therapeutic target. Its dysregulation could provide a new avenue for the development of immunotherapies and cancer treatments. In conclusion, RN7SKP130 is a pseudogene that has been implicated in various biological processes, including immune regulation, cellular differentiation, and neurological functions. Further studies are needed to fully understand its role in these processes and to explore its potential as a diagnostic or therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.