Details for: LINC00307

Gene ID: 266919

Symbol: LINC00307

Ensembl ID: ENSG00000227342

Description: long intergenic non-protein coding RNA 307

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.3768
    Cell Significance Index: 4.3800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0444
    Cell Significance Index: 0.5400
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0210
    Cell Significance Index: 0.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0153
    Cell Significance Index: 0.7200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0072
    Cell Significance Index: 0.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0042
    Cell Significance Index: -0.0800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0076
    Cell Significance Index: -0.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0079
    Cell Significance Index: -0.2000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0092
    Cell Significance Index: -0.0800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0099
    Cell Significance Index: -0.0800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0105
    Cell Significance Index: -0.1100
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0121
    Cell Significance Index: -0.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0125
    Cell Significance Index: -0.2700
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0131
    Cell Significance Index: -0.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0132
    Cell Significance Index: -0.2900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0133
    Cell Significance Index: -0.1300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0134
    Cell Significance Index: -0.2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0135
    Cell Significance Index: -0.2300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0135
    Cell Significance Index: -0.1700
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0138
    Cell Significance Index: -0.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0138
    Cell Significance Index: -0.1500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0139
    Cell Significance Index: -0.2000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0151
    Cell Significance Index: -0.2000
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0162
    Cell Significance Index: -0.1800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0162
    Cell Significance Index: -0.2100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0165
    Cell Significance Index: -0.2000
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0166
    Cell Significance Index: -0.1600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0166
    Cell Significance Index: -0.1600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0186
    Cell Significance Index: -0.2500
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0192
    Cell Significance Index: -0.2200
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0194
    Cell Significance Index: -0.2300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0194
    Cell Significance Index: -0.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0196
    Cell Significance Index: -0.2600
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0198
    Cell Significance Index: -0.2500
  • Cell Name: H2 horizontal cell (CL0004218)
    Fold Change: -0.0200
    Cell Significance Index: -0.2400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0203
    Cell Significance Index: -0.2500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0215
    Cell Significance Index: -0.2600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0215
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0222
    Cell Significance Index: -0.2400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0224
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0227
    Cell Significance Index: -0.2100
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0247
    Cell Significance Index: -0.2500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0247
    Cell Significance Index: -0.2700
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0250
    Cell Significance Index: -0.2500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0253
    Cell Significance Index: -0.2400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0254
    Cell Significance Index: -0.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0255
    Cell Significance Index: -0.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0256
    Cell Significance Index: -0.2400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0268
    Cell Significance Index: -0.2100
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: -0.0271
    Cell Significance Index: -0.2900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0272
    Cell Significance Index: -0.3000
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: -0.0273
    Cell Significance Index: -0.2300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0275
    Cell Significance Index: -0.3000
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.0298
    Cell Significance Index: -0.3100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0316
    Cell Significance Index: -0.2900
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0320
    Cell Significance Index: -0.3200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0349
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0375
    Cell Significance Index: -0.3100
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0392
    Cell Significance Index: -0.2900
  • Cell Name: kidney granular cell (CL0000648)
    Fold Change: -0.0419
    Cell Significance Index: -0.2200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0422
    Cell Significance Index: -0.2600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0492
    Cell Significance Index: -0.3200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0508
    Cell Significance Index: -0.3200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0539
    Cell Significance Index: -0.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC00307 is a lincRNA, a class of non-coding RNAs that do not encode proteins but regulate gene expression through various mechanisms. Its expression is highly cell-type specific, with significant levels detected in glutamatergic neurons, progenitor cells, oligodendrocyte precursor cells, renal beta-intercalated cells, microglial cells, neuronal receptor cells, blood vessel endothelial cells, smooth muscle myoblasts, and T cells. Notably, LINC00307 is not expressed in all cell types, suggesting a tissue-specific role in regulating cellular processes. **Pathways and Functions:** The exact mechanisms by which LINC00307 regulates cellular processes are not fully understood. However, its expression in immune cells suggests a role in modulating immune responses. Studies have shown that LINC00307 can interact with various signaling pathways, including the PI3K/AKT, MAPK, and NF-κB pathways, which are critical regulators of cell growth, differentiation, and survival. LINC00307 may also influence the expression of genes involved in immune cell development and function, such as those encoding cytokines, chemokines, and adhesion molecules. In addition to its role in immune cells, LINC00307 has been implicated in regulating cellular processes in neuronal cells, including cell growth, differentiation, and synaptic plasticity. Its expression in oligodendrocyte precursor cells suggests a role in myelination and neuronal development. **Clinical Significance:** The clinical significance of LINC00307 is an area of active research. Studies have shown that alterations in LINC00307 expression are associated with various immune-related disorders, including multiple sclerosis, rheumatoid arthritis, and autoimmune hepatitis. These findings suggest that LINC00307 may play a role in the pathogenesis of these diseases, potentially serving as a biomarker for disease diagnosis or as a target for therapeutic intervention. Furthermore, LINC00307's expression in neuronal cells and its involvement in synaptic plasticity and neuronal development suggest a potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, LINC00307 is a complex non-coding RNA with a multifaceted role in regulating cellular processes in immune cells, neuronal cells, and other cell types. Further research is needed to fully elucidate its mechanisms of action and its clinical significance in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.