Details for: TRBV12 1

Gene ID: 28579

Symbol: TRBV12 1

Ensembl ID: ENSG00000244661

Description: T cell receptor beta variable 12-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0441
    Cell Significance Index: 0.4800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0006
    Cell Significance Index: -0.1200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0023
    Cell Significance Index: -0.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0029
    Cell Significance Index: -0.1100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0051
    Cell Significance Index: -0.0600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0051
    Cell Significance Index: -0.0500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0052
    Cell Significance Index: -0.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0057
    Cell Significance Index: -0.0800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0059
    Cell Significance Index: -0.0500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0068
    Cell Significance Index: -0.0700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0068
    Cell Significance Index: -0.0800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0069
    Cell Significance Index: -0.0900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0075
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0079
    Cell Significance Index: -0.0800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0081
    Cell Significance Index: -0.0900
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0082
    Cell Significance Index: -0.0700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0082
    Cell Significance Index: -0.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0083
    Cell Significance Index: -0.1000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0087
    Cell Significance Index: -0.0800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0092
    Cell Significance Index: -0.0800
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0095
    Cell Significance Index: -0.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0099
    Cell Significance Index: -0.1000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0100
    Cell Significance Index: -0.1000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0104
    Cell Significance Index: -0.1100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0106
    Cell Significance Index: -0.1300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0109
    Cell Significance Index: -0.1200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0113
    Cell Significance Index: -0.2200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0115
    Cell Significance Index: -0.1000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0117
    Cell Significance Index: -0.0900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0117
    Cell Significance Index: -0.1300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0118
    Cell Significance Index: -0.1200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0119
    Cell Significance Index: -0.1200
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0119
    Cell Significance Index: -0.1100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0120
    Cell Significance Index: -0.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0125
    Cell Significance Index: -0.1200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0125
    Cell Significance Index: -0.1000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0127
    Cell Significance Index: -0.1500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0127
    Cell Significance Index: -0.1100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0128
    Cell Significance Index: -0.1300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0128
    Cell Significance Index: -0.1200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0130
    Cell Significance Index: -0.1500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0135
    Cell Significance Index: -0.1600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0135
    Cell Significance Index: -0.0800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0137
    Cell Significance Index: -0.1200
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0138
    Cell Significance Index: -0.0900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0142
    Cell Significance Index: -0.1200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0142
    Cell Significance Index: -0.1500
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0145
    Cell Significance Index: -0.1000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0147
    Cell Significance Index: -0.0800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0147
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0148
    Cell Significance Index: -0.1200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0157
    Cell Significance Index: -0.1400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0167
    Cell Significance Index: -0.1300
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0176
    Cell Significance Index: -0.1500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0192
    Cell Significance Index: -0.1200
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0202
    Cell Significance Index: -0.1500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0212
    Cell Significance Index: -0.2200
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0217
    Cell Significance Index: -0.2200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0299
    Cell Significance Index: -0.1600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0492
    Cell Significance Index: -0.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV12-1 is a pseudogene, meaning that it is a non-functional copy of a gene that has undergone degeneration through genetic drift or other mechanisms. Despite its pseudogenetic status, TRBV12-1 is significantly expressed in various cell types, including those of the immune system. Its expression is not limited to the thymus, where T cell receptor genes are typically expressed, but is also found in other cell types, such as neurons and endothelial cells. This widespread expression suggests that TRBV12-1 may play a role in regulating cellular processes beyond the immune system. **Pathways and Functions:** The exact pathways and functions of TRBV12-1 are not well understood. However, its expression in various cell types suggests that it may be involved in regulating cellular processes such as proliferation, differentiation, and survival. In the context of the immune system, TRBV12-1 may play a role in modulating T cell responses, although its specific function in this regard remains unclear. The expression of TRBV12-1 in neurons and other non-immune cells suggests that it may also be involved in regulating neural processes, such as synaptic plasticity and neuronal survival. **Clinical Significance:** While the clinical significance of TRBV12-1 is not yet fully understood, its expression in various cell types suggests that it may be involved in the pathogenesis of certain diseases. For example, the expression of TRBV12-1 in microglial cells has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. Additionally, the expression of TRBV12-1 in endothelial cells has been implicated in cardiovascular disease. Further research is needed to fully elucidate the clinical significance of TRBV12-1 and to explore its potential as a therapeutic target. **Conclusion:** In conclusion, the TRBV12-1 gene is a complex and enigmatic molecule that is expressed in various cell types, including those of the immune system. While its functional significance remains unclear, its widespread expression suggests that it may play a role in regulating cellular processes beyond the immune system. Further research is needed to fully elucidate the clinical significance of TRBV12-1 and to explore its potential as a therapeutic target. As an expert immunologist, it is essential to continue to investigate the role of TRBV12-1 in the regulation of immune responses and its potential implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.