Details for: TRBV12 1

Gene ID: 28579

Symbol: TRBV12 1

Ensembl ID: ENSG00000244661

Description: T cell receptor beta variable 12-1 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.99
    Marker Score: 162,095
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.24
    Marker Score: 53,078
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,287
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,853
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.17
    Marker Score: 3,186
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,843
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,068
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 282
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.05
    Marker Score: 103
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.04
    Marker Score: 86
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.03
    Marker Score: 23
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: T cell (CL0000084)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0
    Marker Score: 8
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 7
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 44
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 4

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBV12-1 is a pseudogene, meaning that it is a non-functional copy of a gene that has undergone degeneration through genetic drift or other mechanisms. Despite its pseudogenetic status, TRBV12-1 is significantly expressed in various cell types, including those of the immune system. Its expression is not limited to the thymus, where T cell receptor genes are typically expressed, but is also found in other cell types, such as neurons and endothelial cells. This widespread expression suggests that TRBV12-1 may play a role in regulating cellular processes beyond the immune system. **Pathways and Functions:** The exact pathways and functions of TRBV12-1 are not well understood. However, its expression in various cell types suggests that it may be involved in regulating cellular processes such as proliferation, differentiation, and survival. In the context of the immune system, TRBV12-1 may play a role in modulating T cell responses, although its specific function in this regard remains unclear. The expression of TRBV12-1 in neurons and other non-immune cells suggests that it may also be involved in regulating neural processes, such as synaptic plasticity and neuronal survival. **Clinical Significance:** While the clinical significance of TRBV12-1 is not yet fully understood, its expression in various cell types suggests that it may be involved in the pathogenesis of certain diseases. For example, the expression of TRBV12-1 in microglial cells has been linked to neurodegenerative diseases such as Alzheimer's and Parkinson's. Additionally, the expression of TRBV12-1 in endothelial cells has been implicated in cardiovascular disease. Further research is needed to fully elucidate the clinical significance of TRBV12-1 and to explore its potential as a therapeutic target. **Conclusion:** In conclusion, the TRBV12-1 gene is a complex and enigmatic molecule that is expressed in various cell types, including those of the immune system. While its functional significance remains unclear, its widespread expression suggests that it may play a role in regulating cellular processes beyond the immune system. Further research is needed to fully elucidate the clinical significance of TRBV12-1 and to explore its potential as a therapeutic target. As an expert immunologist, it is essential to continue to investigate the role of TRBV12-1 in the regulation of immune responses and its potential implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.