Details for: IFNA14

Gene ID: 3448

Symbol: IFNA14

Ensembl ID: ENSG00000228083

Description: interferon alpha 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.1641
    Cell Significance Index: 1.9600
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.0659
    Cell Significance Index: 0.6500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0425
    Cell Significance Index: 0.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0162
    Cell Significance Index: 0.2300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0096
    Cell Significance Index: 0.0900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.0060
    Cell Significance Index: 0.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0041
    Cell Significance Index: 0.0800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.0033
    Cell Significance Index: 0.0300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.0032
    Cell Significance Index: 0.0200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0027
    Cell Significance Index: 0.0400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0031
    Cell Significance Index: -0.6300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0031
    Cell Significance Index: -0.0300
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0207
    Cell Significance Index: -0.4000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0211
    Cell Significance Index: -0.2300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0213
    Cell Significance Index: -0.5400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0227
    Cell Significance Index: -0.2600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0234
    Cell Significance Index: -0.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0252
    Cell Significance Index: -0.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0266
    Cell Significance Index: -0.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0311
    Cell Significance Index: -0.6200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0339
    Cell Significance Index: -0.5800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0350
    Cell Significance Index: -0.4200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0356
    Cell Significance Index: -0.4700
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0358
    Cell Significance Index: -0.4100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0375
    Cell Significance Index: -0.4400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0382
    Cell Significance Index: -0.6200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0401
    Cell Significance Index: -0.4300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0435
    Cell Significance Index: -0.5000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0437
    Cell Significance Index: -0.5900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0479
    Cell Significance Index: -0.6600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0488
    Cell Significance Index: -0.6000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0499
    Cell Significance Index: -0.6300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0514
    Cell Significance Index: -0.6500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0566
    Cell Significance Index: -0.5800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0566
    Cell Significance Index: -0.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0596
    Cell Significance Index: -0.8600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0597
    Cell Significance Index: -0.7400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0612
    Cell Significance Index: -0.5800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0631
    Cell Significance Index: -0.8400
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0668
    Cell Significance Index: -0.7700
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0682
    Cell Significance Index: -0.5200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0713
    Cell Significance Index: -0.8400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0751
    Cell Significance Index: -0.9700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1096
    Cell Significance Index: -0.9700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1139
    Cell Significance Index: -1.0000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1153
    Cell Significance Index: -1.5100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1238
    Cell Significance Index: -1.3300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1293
    Cell Significance Index: -0.6900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1454
    Cell Significance Index: -1.3800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1465
    Cell Significance Index: -0.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFNA14 is a type I interferon, which is characterized by its ability to induce antiviral and immunomodulatory responses. It is produced by various cell types, including pericytes, immature innate lymphoid cells, cardiac endothelial cells, and plasmacytoid dendritic cells. IFNA14 has a specific receptor, IFNAR1, which binds to the interferon-alpha/beta (IFN-α/β) family of receptors, triggering a signaling cascade that activates the JAK/STAT pathway. **Pathways and Functions:** IFNA14 is involved in various signaling pathways, including: 1. **Adaptive Immune Response**: IFNA14 plays a role in the regulation of B cell differentiation and proliferation, which is essential for the adaptive immune response against viral infections. 2. **Cytokine-Mediated Signaling Pathway**: IFNA14 interacts with other cytokines, such as TNF-α and IL-6, to modulate the immune response. 3. **Interferon Alpha/Beta Signaling**: IFNA14 is part of the IFN-α/β signaling pathway, which is essential for the induction of antiviral and immunomodulatory responses. 4. **Natural Killer Cell Activation**: IFNA14 is involved in the activation of natural killer cells, which are crucial for the elimination of infected cells. **Clinical Significance:** IFNA14 has been implicated in various diseases, including: 1. **Respiratory Syncytial Virus (RSV) Infection**: IFNA14 has been shown to play a role in the pathogenesis of RSV infection, which is a major cause of respiratory illness in infants and young children. 2. **SARS-CoV-2 Infection**: IFNA14 has been implicated in the modulation of innate and adaptive immune responses against SARS-CoV-2, which is the causative agent of COVID-19. 3. **Infectious Diseases**: IFNA14 has been shown to play a role in the immune response against various infectious diseases, including HIV, herpes simplex virus, and influenza. In conclusion, IFNA14 is a crucial component of the innate immune response against viral infections. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the complex interactions between IFNA14 and other cytokines and immune cells. Further research is needed to fully elucidate the mechanisms of IFNA14 in the immune response and to develop novel therapeutic strategies for the treatment of infectious diseases.

Genular Protein ID: 204301350

Symbol: IFN14_HUMAN

Name: Interferon alpha-14

UniProtKB Accession Codes:

P01570 Q5VZ56 Q7M4S1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6163083

Title: The structure of eight distinct cloned human leukocyte interferon cDNAs.

PubMed ID: 6163083

DOI: 10.1038/290020a0

PubMed ID: 6165082

Title: DNA sequence of two closely linked human leukocyte interferon genes.

PubMed ID: 6165082

DOI: 10.1126/science.6165082

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1634550

Title: Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.

PubMed ID: 1634550

DOI: 10.1016/s0021-9258(18)42167-9

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 7765487

Title: Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes.

PubMed ID: 7765487

DOI: 10.1271/bbb.58.1714

PubMed ID: 8910771

Title: Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population.

PubMed ID: 8910771

DOI: 10.1089/jir.1996.16.853

Sequence Information:

  • Length: 189
  • Mass: 22063
  • Checksum: B6B71E2F0D644FE7
  • Sequence:
    • MALPFALMMA LVVLSCKSSC SLGCNLSQTH SLNNRRTLML MAQMRRISPF SCLKDRHDFE 
FPQEEFDGNQ FQKAQAISVL HEMMQQTFNL FSTKNSSAAW DETLLEKFYI ELFQQMNDLE 
ACVIQEVGVE ETPLMNEDSI LAVKKYFQRI TLYLMEKKYS PCAWEVVRAE IMRSLSFSTN 
LQKRLRRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.