Gene IFNA14 - ENSG00000228083 | NCBI Gene ID: 3448

Details for: IFNA14

Gene ID: 3448

Symbol: IFNA14

Ensembl ID: ENSG00000228083

Description: interferon alpha 14

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Disease
(R-HSA-1643685)
Evasion by rsv of host interferon responses
(R-HSA-9833109)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon signaling
(R-HSA-913531)
Regulation of ifna/ifnb signaling
(R-HSA-912694)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rsv-host interactions
(R-HSA-9833110)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Traf6 mediated irf7 activation
(R-HSA-933541)
Viral infection pathways
(R-HSA-9824446)
Adaptive immune response
(GO:0002250)
B cell differentiation
(GO:0030183)
B cell proliferation
(GO:0042100)
Cellular response to virus
(GO:0098586)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Cytokine receptor binding
(GO:0005126)
Defense response to virus
(GO:0051607)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Humoral immune response
(GO:0006959)
Natural killer cell activation involved in immune response
(GO:0002323)
Positive regulation of peptidyl-serine phosphorylation of stat protein
(GO:0033141)
Protein binding
(GO:0005515)
Response to exogenous dsrna
(GO:0043330)
T cell activation involved in immune response
(GO:0002286)
Type i interferon-mediated signaling pathway
(GO:0060337)
Type i interferon receptor binding
(GO:0005132)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pericyte (CL0000669)
Fold Change: 0.72
Marker Score: 420
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.59
Marker Score: 1195
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.49
Marker Score: 929
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.34
Marker Score: 204
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3
Marker Score: 4749
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.26
Marker Score: 1547
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.15
Marker Score: 71
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.09
Marker Score: 39
Cell Name: plasmacytoid dendritic cell, human (CL0001058)
Fold Change: 0.04
Marker Score: 11
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.04
Marker Score: 80
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.03
Marker Score: 8
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.03
Marker Score: 32
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.02
Marker Score: 7
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.02
Marker Score: 5.5
Cell Name: neutrophil (CL0000775)
Fold Change: 0.01
Marker Score: 9
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.01
Marker Score: 8
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.01
Marker Score: 34
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.01
Marker Score: 18
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.01
Marker Score: 9
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.01
Marker Score: 6
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.01
Marker Score: 5.5
Cell Name: mast cell (CL0000097)
Fold Change: 0.01
Marker Score: 6
Cell Name: stromal cell (CL0000499)
Fold Change: 0.01
Marker Score: 12
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.01
Marker Score: 26
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.01
Marker Score: 6
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.01
Marker Score: 9
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.01
Marker Score: 18
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.01
Marker Score: 5
Cell Name: monocyte (CL0000576)
Fold Change: 0.01
Marker Score: 9
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.01
Marker Score: 7
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.01
Marker Score: 6
Cell Name: secretory cell (CL0000151)
Fold Change: 0.01
Marker Score: 12
Cell Name: macrophage (CL0000235)
Fold Change: 0.01
Marker Score: 7
Cell Name: fibroblast (CL0000057)
Fold Change: 0.01
Marker Score: 5
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0
Marker Score: 9
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0
Marker Score: 9
Cell Name: neuron (CL0000540)
Fold Change: 0
Marker Score: 8
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0
Marker Score: 6
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0
Marker Score: 9
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0
Marker Score: 6

Hover over a box to see details here...

**Key characteristics:** * IFNA14 is a protein of the interferon alpha family. * It is expressed in high levels in the blood of patients with viral infections. * It plays a role in the regulation of immune responses to viral infection. **Pathways and functions:** * IFNA14 is a key regulator of innate immune responses. * It is involved in the induction of type I interferons, which are cytokines that activate macrophages and other immune cells. * It also plays a role in the regulation of adaptive immune responses, including the activation of antigen-presenting cells and the generation of cytotoxic T cells. * IFNA14 is also involved in the regulation of inflammation. **Clinical significance:** * Mutations in IFNA14 have been linked to the development of several autoimmune diseases, including systemic sclerosis, lupus, and rheumatoid arthritis. * IFNA14 is also a potential therapeutic target for cancer. **Additional notes:** * IFNA14 is a highly conserved protein that is found in all vertebrates. * It is a secreted protein that is produced by cells in the blood, lungs, and other tissues. * It is a potent activator of the innate immune system.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interferon alpha-14

Genular Protein ID: 204301350

Symbol: IFN14_HUMAN

Name: Interferon alpha-14

UniProtKB Accession Codes:

P01570 Q5VZ56 Q7M4S1

Database IDs:

Citations:

PubMed ID: 6163083

Title: The structure of eight distinct cloned human leukocyte interferon cDNAs.

PubMed ID: 6163083

DOI: 10.1038/290020a0

PubMed ID: 6165082

Title: DNA sequence of two closely linked human leukocyte interferon genes.

PubMed ID: 6165082

DOI: 10.1126/science.6165082

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1634550

Title: Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.

PubMed ID: 1634550

DOI: 10.1016/s0021-9258(18)42167-9

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 7765487

Title: Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes.

PubMed ID: 7765487

DOI: 10.1271/bbb.58.1714

PubMed ID: 8910771

Title: Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population.

PubMed ID: 8910771

DOI: 10.1089/jir.1996.16.853

Sequence Information:

Length: 189
Mass: 22063
Checksum: B6B71E2F0D644FE7
Sequence:

MALPFALMMA LVVLSCKSSC SLGCNLSQTH SLNNRRTLML MAQMRRISPF SCLKDRHDFE 
FPQEEFDGNQ FQKAQAISVL HEMMQQTFNL FSTKNSSAAW DETLLEKFYI ELFQQMNDLE 
ACVIQEVGVE ETPLMNEDSI LAVKKYFQRI TLYLMEKKYS PCAWEVVRAE IMRSLSFSTN 
LQKRLRRKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IFNA14

Associated with

Cells (max top 100)

Other Information

The structure of eight distinct cloned human leukocyte interferon cDNAs. PubMed ID: 6163083

DNA sequence of two closely linked human leukocyte interferon genes. PubMed ID: 6165082

Structural relationship of human interferon alpha genes and pseudogenes. PubMed ID: 4057246

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and characterization of multiple components of human lymphoblastoid interferon-alpha. PubMed ID: 1634550

Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes. PubMed ID: 9425112

Identification of glycosylated subtypes of interferon-alpha produced by human leukocytes. PubMed ID: 7765487

Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population. PubMed ID: 8910771