Details for: LCE1D

Gene ID: 353134

Symbol: LCE1D

Ensembl ID: ENSG00000172155

Description: late cornified envelope 1D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.2766
    Cell Significance Index: 3.6400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1821
    Cell Significance Index: 2.3800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.1047
    Cell Significance Index: 1.1400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.0292
    Cell Significance Index: 0.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0074
    Cell Significance Index: -1.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0096
    Cell Significance Index: -1.9200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0126
    Cell Significance Index: -0.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0291
    Cell Significance Index: -0.3400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0322
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0394
    Cell Significance Index: -0.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0656
    Cell Significance Index: -1.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0683
    Cell Significance Index: -1.7400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0725
    Cell Significance Index: -0.9700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0772
    Cell Significance Index: -0.9100
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0794
    Cell Significance Index: -1.0900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0865
    Cell Significance Index: -0.9900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0884
    Cell Significance Index: -1.1200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0925
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0986
    Cell Significance Index: -1.0400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1045
    Cell Significance Index: -1.5900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1224
    Cell Significance Index: -1.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1291
    Cell Significance Index: -1.1900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1425
    Cell Significance Index: -1.7100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1447
    Cell Significance Index: -1.7300
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.1490
    Cell Significance Index: -1.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1582
    Cell Significance Index: -2.1700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1584
    Cell Significance Index: -1.9800
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1595
    Cell Significance Index: -1.9400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.1639
    Cell Significance Index: -1.9000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1698
    Cell Significance Index: -1.7300
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1716
    Cell Significance Index: -1.9800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1717
    Cell Significance Index: -2.1100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.1752
    Cell Significance Index: -1.8600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1753
    Cell Significance Index: -1.0400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1755
    Cell Significance Index: -2.0900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1819
    Cell Significance Index: -1.9900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1847
    Cell Significance Index: -1.1600
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1894
    Cell Significance Index: -2.0600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1909
    Cell Significance Index: -1.7800
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.1910
    Cell Significance Index: -2.0800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2046
    Cell Significance Index: -2.0900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2049
    Cell Significance Index: -2.0300
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.2108
    Cell Significance Index: -2.3100
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.2183
    Cell Significance Index: -2.0500
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2333
    Cell Significance Index: -1.7000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2422
    Cell Significance Index: -1.8600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.2614
    Cell Significance Index: -1.4000
  • Cell Name: reticular cell (CL0000432)
    Fold Change: -0.3166
    Cell Significance Index: -2.0200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: -0.7556
    Cell Significance Index: -2.2500
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -1.0006
    Cell Significance Index: -2.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LCE1D is a member of the late cornified envelope family of proteins, which are primarily associated with the formation and maintenance of the cornified envelope, a key component of the skin's outermost layer. The protein is characterized by its unique structure and interactions with other cellular components. Notably, LCE1D exhibits identical protein binding capabilities, suggesting its potential role in protein-protein interactions and signaling pathways. **Pathways and Functions:** LCE1D is involved in several cellular processes, including: 1. **Cellular response to calcium ion**: LCE1D interacts with calcium ions, which play a crucial role in various cellular signaling pathways, including cell differentiation, proliferation, and apoptosis. 2. **Cognition and developmental biology**: LCE1D is expressed in the brain and other tissues, suggesting its involvement in neural development, synaptic plasticity, and cognitive functions. 3. **Formation of the cornified envelope**: As a member of the late cornified envelope family, LCE1D contributes to the formation and maintenance of the cornified envelope, a critical component of the skin's barrier function. 4. **Keratinization**: LCE1D is also involved in the process of keratinization, which is essential for the development and maintenance of stratified epithelia. **Clinical Significance:** The LCE1D gene has been identified in various diseases, including: 1. **Skin disorders**: Mutations in LCE1D have been associated with skin disorders, such as epidermolysis bullosa simplex, a condition characterized by blistering and skin fragility. 2. **Neurological disorders**: LCE1D has been implicated in neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease, suggesting its potential role in synaptic plasticity and cognitive functions. 3. **Cancer**: LCE1D expression has been altered in various types of cancer, including breast, lung, and colon cancer, highlighting its potential as a biomarker or therapeutic target. In conclusion, the LCE1D gene plays a multifaceted role in various cellular processes, from development and tissue homeostasis to disease pathogenesis. Further research is necessary to fully elucidate the mechanisms underlying LCE1D's functions and to explore its therapeutic potential in various diseases.

Genular Protein ID: 828603018

Symbol: LCE1D_HUMAN

Name: Late cornified envelope protein 1D

UniProtKB Accession Codes:

Q5T752

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15854049

Title: Late cornified envelope family in differentiating epithelia -- response to calcium and ultraviolet irradiation.

PubMed ID: 15854049

DOI: 10.1111/j.0022-202x.2005.23699.x

PubMed ID: 36804407

Title: CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with Late Cornified Envelope Proteins.

PubMed ID: 36804407

DOI: 10.1016/j.jid.2023.01.022

Sequence Information:

  • Length: 114
  • Mass: 11230
  • Checksum: 809EE3813C377446
  • Sequence:
    • MSCQQSQQQC QPPPKCTPKC TPKCPAPKCP PKCPPVSSCC SVSSGGCCGS SSGGGCGSNS 
GGCCSSGGGG CCLSHHRRHR SHRRRPQSSD CCSQPSGGSS CCGGGSSQHS GGCC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.