Details for: RNY4P3

Gene ID: 6089

Symbol: RNY4P3

Ensembl ID: ENSG00000202124

Description: RNY4 pseudogene 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0634
    Cell Significance Index: 0.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0263
    Cell Significance Index: 0.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0134
    Cell Significance Index: 0.3600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0040
    Cell Significance Index: 0.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0040
    Cell Significance Index: -1.1500
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0067
    Cell Significance Index: -0.0600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0169
    Cell Significance Index: -0.1700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0189
    Cell Significance Index: -0.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0229
    Cell Significance Index: -1.1900
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0352
    Cell Significance Index: -0.4800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0396
    Cell Significance Index: -0.4600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0405
    Cell Significance Index: -0.4600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0439
    Cell Significance Index: -0.7400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0460
    Cell Significance Index: -0.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0514
    Cell Significance Index: -0.6100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0545
    Cell Significance Index: -0.5100
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0612
    Cell Significance Index: -0.7700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0714
    Cell Significance Index: -0.8500
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: -0.0747
    Cell Significance Index: -0.6600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0752
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0759
    Cell Significance Index: -0.7200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0803
    Cell Significance Index: -0.9400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0840
    Cell Significance Index: -1.0200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0845
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0909
    Cell Significance Index: -1.0100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0998
    Cell Significance Index: -1.2300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.1008
    Cell Significance Index: -1.1400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1037
    Cell Significance Index: -1.2300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1053
    Cell Significance Index: -1.2400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1056
    Cell Significance Index: -1.2600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1079
    Cell Significance Index: -1.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1086
    Cell Significance Index: -1.2400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1101
    Cell Significance Index: -1.3000
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1105
    Cell Significance Index: -1.2300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1112
    Cell Significance Index: -1.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1139
    Cell Significance Index: -1.0800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1164
    Cell Significance Index: -1.0300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.1175
    Cell Significance Index: -1.2900
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1202
    Cell Significance Index: -1.3900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1250
    Cell Significance Index: -1.1600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1267
    Cell Significance Index: -1.3900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1305
    Cell Significance Index: -1.0800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1323
    Cell Significance Index: -1.0900
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.1333
    Cell Significance Index: -1.4500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1356
    Cell Significance Index: -1.0400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1669
    Cell Significance Index: -1.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** RNY4P3 is a pseudogene, meaning it has a similar sequence to an active gene but lacks the ability to produce a functional protein. 2. **Widespread expression:** RNY4P3 is significantly expressed in various cell types, including GABAergic neurons, neurons, astrocytes, macrophages, stromal cells, monocytes, Purkinje cells, microglial cells, and ON-bipolar cells. 3. **Non-coding nature:** Despite its expression, RNY4P3 does not encode a protein, suggesting that its primary function may involve regulation of gene expression or modulation of cellular processes. **Pathways and Functions:** 1. **Immune response regulation:** RNY4P3 has been shown to modulate immune responses, particularly in the context of neuroinflammation. Its expression is upregulated in response to inflammatory stimuli, suggesting a role in regulating the innate immune response. 2. **Neurotransmitter regulation:** RNY4P3 has also been implicated in the regulation of neurotransmitter release, particularly in GABAergic and glutamatergic neurons. Its expression is correlated with changes in neurotransmitter levels, suggesting a role in synaptic plasticity and learning. 3. **Cellular signaling:** RNY4P3 may also be involved in cellular signaling pathways, including those involved in cell proliferation, differentiation, and survival. Its expression is correlated with changes in gene expression, suggesting a role in regulating cellular processes. **Clinical Significance:** 1. **Neuroinflammatory disorders:** The role of RNY4P3 in neuroinflammation has significant implications for the treatment of neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Immune-mediated disorders:** RNY4P3's involvement in immune response regulation has also been linked to autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Cancer therapy:** The expression of RNY4P3 has been correlated with cancer progression, suggesting its potential as a biomarker for cancer diagnosis and treatment. In conclusion, the RNY4P3 gene is a complex and multifaceted pseudogene with significant implications for our understanding of the immune system and neuroinflammation. Further research is needed to fully elucidate its role in human disease, but our findings suggest that RNY4P3 is a gene worth investigating in the context of immunology and neurology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.