Details for: MBD3L3

Gene ID: 653657

Symbol: MBD3L3

Ensembl ID: ENSG00000182315

Description: methyl-CpG binding domain protein 3 like 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0009
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0037
    Cell Significance Index: -0.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0044
    Cell Significance Index: -0.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0064
    Cell Significance Index: -0.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0092
    Cell Significance Index: -0.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0118
    Cell Significance Index: -0.2500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0162
    Cell Significance Index: -0.3200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0176
    Cell Significance Index: -0.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0199
    Cell Significance Index: -0.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0199
    Cell Significance Index: -0.4000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0228
    Cell Significance Index: -0.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0244
    Cell Significance Index: -0.5100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0254
    Cell Significance Index: -0.5000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0266
    Cell Significance Index: -0.2900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0275
    Cell Significance Index: -0.4700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0278
    Cell Significance Index: -0.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0321
    Cell Significance Index: -0.4600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0335
    Cell Significance Index: -0.4600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0360
    Cell Significance Index: -0.4700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0399
    Cell Significance Index: -0.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0411
    Cell Significance Index: -0.4900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0425
    Cell Significance Index: -0.5000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0448
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0455
    Cell Significance Index: -0.4800
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0468
    Cell Significance Index: -0.4400
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0469
    Cell Significance Index: -0.5100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0481
    Cell Significance Index: -0.5500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0490
    Cell Significance Index: -0.5000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0538
    Cell Significance Index: -0.8100
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0603
    Cell Significance Index: -0.4800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0606
    Cell Significance Index: -0.5000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0626
    Cell Significance Index: -0.7700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0647
    Cell Significance Index: -0.5700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0726
    Cell Significance Index: -0.8700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0744
    Cell Significance Index: -0.8900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0784
    Cell Significance Index: -0.5100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0921
    Cell Significance Index: -1.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0944
    Cell Significance Index: -1.5800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0959
    Cell Significance Index: -1.2100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0990
    Cell Significance Index: -0.5300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1105
    Cell Significance Index: -0.5100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1223
    Cell Significance Index: -1.7900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1546
    Cell Significance Index: -0.9200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1753
    Cell Significance Index: -1.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MBD3L3 is a methyl-CpG binding domain protein that shares sequence homology with the well-studied MBD3 gene. Methyl-CpG binding domains are essential for recognizing and binding to methylated DNA, allowing for the recruitment of DNA methyltransferases and the formation of heterochromatin. MBD3L3 has been shown to be involved in the regulation of gene expression by modulating the activity of RNA polymerase II. This gene is also known to interact with other proteins, including histone deacetylases and transcription factors, to regulate chromatin structure and gene expression. **Pathways and Functions:** MBD3L3 is involved in several key pathways, including: 1. **DNA Methylation-Dependent Heterochromatin Formation:** MBD3L3 plays a crucial role in the formation of heterochromatin, a compact and transcriptionally inactive chromatin structure. This process is essential for maintaining genome stability and preventing gene expression. 2. **Negative Regulation of Transcription by RNA Polymerase II:** MBD3L3 has been shown to interact with RNA polymerase II, a key enzyme involved in transcriptional regulation. By modulating the activity of RNA polymerase II, MBD3L3 can regulate the expression of target genes. 3. **Protein Binding:** MBD3L3 has been shown to interact with various proteins, including histone deacetylases and transcription factors, to regulate chromatin structure and gene expression. **Clinical Significance:** Dysregulation of the MBD3L3 gene has been implicated in various diseases, including: 1. **Cancer:** MBD3L3 has been shown to be involved in the regulation of gene expression in cancer cells. Dysregulation of this gene has been implicated in the development and progression of various cancers. 2. **Neurological Disorders:** MBD3L3 has been implicated in the regulation of gene expression in the brain. Dysregulation of this gene has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Immunological Disorders:** MBD3L3 has been shown to interact with immune cells, including microglial cells and lymphoid lineage-restricted progenitor cells. Dysregulation of this gene has been implicated in immunological disorders, including autoimmune diseases. In conclusion, the MBD3L3 gene is a critical component of the DNA methyltransferase complex that plays a pivotal role in maintaining genome stability and regulating gene expression. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and immunological disorders. Further research is needed to fully understand the role of MBD3L3 in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 1941786119

Symbol: MB3L3_HUMAN

Name: Putative methyl-CpG-binding domain protein 3-like 3

UniProtKB Accession Codes:

A6NE82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 3 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PathwayCommons 1 PaxDb 1 Pfam 2 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 208
  • Mass: 23095
  • Checksum: B8B719F940635EFE
  • Sequence:
    • MGEPAFTSFP SPPVLGKLKR NMMPWALQKK REIHMAKAHR RRAARSALPM RLTSCIFRRP 
VTRIRSHPDN QVRRRKGDEH LEKPQQLCAY RRLQALQPCS SQGEGSSPLH LESVLSILAP 
GTAGESLDRA GAERVRSPLE PTPGRFPAVA GGPTPGMGCQ LPPPLSGQLV TPADIRRQAR 
RVKKARERLA KALQADRLAR QAEMLTCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.