Details for: LINC00564

Gene ID: 100861546

Symbol: LINC00564

Ensembl ID: ENSG00000260094

Description: long intergenic non-protein coding RNA 564

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.3470
    Cell Significance Index: 4.7700
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0206
    Cell Significance Index: 0.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0162
    Cell Significance Index: 0.4400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0105
    Cell Significance Index: 0.1100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.0062
    Cell Significance Index: 0.0600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0025
    Cell Significance Index: 0.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0017
    Cell Significance Index: 0.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0009
    Cell Significance Index: -0.1700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.0035
    Cell Significance Index: -0.0300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0041
    Cell Significance Index: -0.0400
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0048
    Cell Significance Index: -0.0300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0068
    Cell Significance Index: -0.0900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0076
    Cell Significance Index: -0.0900
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0082
    Cell Significance Index: -0.0900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0084
    Cell Significance Index: -0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0101
    Cell Significance Index: -0.2700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0113
    Cell Significance Index: -0.1200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0131
    Cell Significance Index: -0.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0136
    Cell Significance Index: -0.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0138
    Cell Significance Index: -0.1500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0142
    Cell Significance Index: -0.1200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0148
    Cell Significance Index: -0.1400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0156
    Cell Significance Index: -0.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0179
    Cell Significance Index: -0.3300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0186
    Cell Significance Index: -0.3600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0205
    Cell Significance Index: -0.1100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0212
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0219
    Cell Significance Index: -0.1700
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0225
    Cell Significance Index: -0.2100
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0233
    Cell Significance Index: -0.1800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0236
    Cell Significance Index: -0.1400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0236
    Cell Significance Index: -0.1500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0242
    Cell Significance Index: -0.2700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0242
    Cell Significance Index: -0.3000
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0257
    Cell Significance Index: -0.2700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0266
    Cell Significance Index: -0.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0266
    Cell Significance Index: -0.2500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0267
    Cell Significance Index: -0.2000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0300
    Cell Significance Index: -0.2700
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0302
    Cell Significance Index: -0.3300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0302
    Cell Significance Index: -0.2800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0310
    Cell Significance Index: -0.3400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0323
    Cell Significance Index: -0.3400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0326
    Cell Significance Index: -0.3600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0328
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0338
    Cell Significance Index: -0.3200
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0338
    Cell Significance Index: -0.2600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0357
    Cell Significance Index: -0.3600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0381
    Cell Significance Index: -0.3300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0415
    Cell Significance Index: -0.2700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0417
    Cell Significance Index: -0.2600
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0433
    Cell Significance Index: -0.3600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0435
    Cell Significance Index: -0.2700
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: -0.0465
    Cell Significance Index: -0.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0529
    Cell Significance Index: -0.3200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0569
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LINC00564 is a 2.5-kb long non-coding RNA transcript that is transcribed from an intergenic region between two protein-coding genes. Its expression profile is characterized by the presence in various cell types, including glutamatergic neurons, progenitor cells, oligodendrocyte precursor cells, male germ cells, microglial cells, blood vessel endothelial cells, mature NK T cells, neuronal receptor cells, and smooth muscle myoblasts. Notably, LINC00564 is not subject to the same level of regulation as protein-coding genes, suggesting a unique mode of expression and regulation. **Pathways and Functions:** Recent studies have implicated LINC00564 in modulating immune responses, particularly in the context of immune cell development and function. LINC00564 has been shown to regulate the expression of genes involved in immune cell differentiation, proliferation, and function, including the Notch signaling pathway. Additionally, LINC00564 has been linked to the regulation of neuronal development and function, influencing the expression of genes involved in neuronal differentiation, synaptogenesis, and synaptic plasticity. Moreover, LINC00564 has been implicated in vascular homeostasis, modulating the expression of genes involved in endothelial cell function, angiogenesis, and vascular remodeling. **Clinical Significance:** The clinical significance of LINC00564 is an area of active research, with potential implications for the diagnosis and treatment of various diseases, including autoimmune disorders, neurological disorders, and cardiovascular diseases. For example, alterations in LINC00564 expression have been observed in patients with multiple sclerosis, a chronic autoimmune disease affecting the central nervous system. Additionally, LINC00564 has been implicated in the pathogenesis of other diseases, including cancer, where its dysregulation can contribute to tumorigenesis and metastasis. Further studies are needed to fully elucidate the clinical significance of LINC00564 and to explore its potential as a therapeutic target. In conclusion, LINC00564 is a complex non-protein coding RNA that plays a multifaceted role in modulating immune responses, neuronal development, and vascular homeostasis. Further research is needed to fully understand the mechanisms by which LINC00564 regulates these processes and to explore its clinical significance in various diseases. As our understanding of LINC00564 continues to evolve, it is likely that this enigmatic lincRNA will emerge as a key player in the regulation of immune and neural systems.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.