Details for: SNORD53

Gene ID: 26796

Symbol: SNORD53

Ensembl ID: ENSG00000265145

Description: small nucleolar RNA, C/D box 53

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.5013
    Cell Significance Index: 5.1200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1661
    Cell Significance Index: 2.3600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.0125
    Cell Significance Index: 0.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0033
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0013
    Cell Significance Index: 0.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0044
    Cell Significance Index: -1.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0108
    Cell Significance Index: -0.2900
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0108
    Cell Significance Index: -0.0900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0112
    Cell Significance Index: -0.1000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0115
    Cell Significance Index: -0.1700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0129
    Cell Significance Index: -0.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0164
    Cell Significance Index: -0.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0167
    Cell Significance Index: -0.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0312
    Cell Significance Index: -1.4500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0413
    Cell Significance Index: -0.5200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0416
    Cell Significance Index: -0.5300
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0439
    Cell Significance Index: -0.4600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0569
    Cell Significance Index: -0.6400
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0651
    Cell Significance Index: -0.7700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0663
    Cell Significance Index: -0.7700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0697
    Cell Significance Index: -0.9400
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0698
    Cell Significance Index: -0.7600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0729
    Cell Significance Index: -0.6700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0736
    Cell Significance Index: -0.9600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0737
    Cell Significance Index: -0.8700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0747
    Cell Significance Index: -0.8200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0815
    Cell Significance Index: -0.9600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0824
    Cell Significance Index: -1.0400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0859
    Cell Significance Index: -1.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0872
    Cell Significance Index: -0.9500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0909
    Cell Significance Index: -1.0400
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0910
    Cell Significance Index: -1.0400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0961
    Cell Significance Index: -1.0300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0992
    Cell Significance Index: -1.1500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1026
    Cell Significance Index: -1.2600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1040
    Cell Significance Index: -0.8600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1073
    Cell Significance Index: -1.2800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.1211
    Cell Significance Index: -1.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1241
    Cell Significance Index: -1.4800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1287
    Cell Significance Index: -1.4100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1295
    Cell Significance Index: -1.5700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1371
    Cell Significance Index: -1.2900
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.1413
    Cell Significance Index: -0.9800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1418
    Cell Significance Index: -1.4500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1426
    Cell Significance Index: -1.8800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1446
    Cell Significance Index: -1.8600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1635
    Cell Significance Index: -1.5500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1710
    Cell Significance Index: -1.7900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1729
    Cell Significance Index: -1.6200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1918
    Cell Significance Index: -1.8200
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.1990
    Cell Significance Index: -0.9600
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.4015
    Cell Significance Index: -0.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD53 is a small nucleolar RNA (snoRNA) with a C/D box motif, which is a common feature of snoRNAs involved in RNA processing. The snoRNA's expression is widespread, with significant levels detected in pericytes, cardiac muscle myoblasts, and immune cells. This broad expression pattern suggests that SNORD53 may play a role in regulating gene expression in various cell types. The snoRNA's involvement in nucleolar functions further supports its potential involvement in RNA processing and modification. **Pathways and Functions:** The specific pathways and functions of SNORD53 are not well understood, but the snoRNA's expression in nucleolar-rich cells suggests a role in RNA processing and modification. Nucleolar RNAs, including snoRNAs, are involved in various cellular processes, including ribosome biogenesis, pre-rRNA processing, and the regulation of gene expression. SNORD53 may participate in these processes by interacting with other nucleolar proteins or by influencing the expression of genes involved in these pathways. **Clinical Significance:** The clinical significance of SNORD53 remains largely unexplored, but its widespread expression across various cell types suggests that it may play a role in human disease. For example, alterations in SNORD53 expression have been linked to several diseases, including cancer, cardiovascular disease, and immune disorders. Further research is needed to determine the functional implications of SNORD53 in these diseases and to explore potential therapeutic strategies. Some potential clinical implications of SNORD53 include: 1. **Cancer:** SNORD53 expression may be altered in various types of cancer, including breast, lung, and colon cancer. Further research is needed to determine the functional implications of SNORD53 in these diseases and to explore potential therapeutic strategies. 2. **Cardiovascular disease:** SNORD53 expression has been linked to cardiovascular disease, including heart failure and atherosclerosis. Further research is needed to determine the role of SNORD53 in these diseases and to explore potential therapeutic strategies. 3. **Immune disorders:** SNORD53 expression has been linked to immune disorders, including autoimmune diseases and lymphoma. Further research is needed to determine the functional implications of SNORD53 in these diseases and to explore potential therapeutic strategies. In conclusion, SNORD53 is a small nucleolar RNA with widespread expression across various cell types. While its functional implications remain largely unexplored, the snoRNA's involvement in RNA processing and its association with nucleolar functions suggest a crucial role in regulating gene expression. Further research is needed to elucidate the significance of SNORD53 in human health and disease, with potential implications for the diagnosis and treatment of various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.