Details for: IGHV3 75

Gene ID: 28407

Symbol: IGHV3 75

Ensembl ID: ENSG00000254176

Description: immunoglobulin heavy variable 3-75 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1495
    Cell Significance Index: 1.6900
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0119
    Cell Significance Index: 0.1200
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0015
    Cell Significance Index: 0.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0028
    Cell Significance Index: -0.1500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0063
    Cell Significance Index: -0.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0094
    Cell Significance Index: -0.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0198
    Cell Significance Index: -0.2000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0210
    Cell Significance Index: -0.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0231
    Cell Significance Index: -0.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0310
    Cell Significance Index: -0.5700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0355
    Cell Significance Index: -0.4500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0388
    Cell Significance Index: -0.5000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0391
    Cell Significance Index: -0.4000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0425
    Cell Significance Index: -0.4100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0464
    Cell Significance Index: -0.5600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0475
    Cell Significance Index: -0.5400
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0480
    Cell Significance Index: -0.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0493
    Cell Significance Index: -0.7300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0497
    Cell Significance Index: -0.5500
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0512
    Cell Significance Index: -0.5400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0515
    Cell Significance Index: -0.7400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0519
    Cell Significance Index: -0.5300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0526
    Cell Significance Index: -0.6800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0534
    Cell Significance Index: -0.6500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0541
    Cell Significance Index: -0.5900
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0546
    Cell Significance Index: -0.6500
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0551
    Cell Significance Index: -0.5800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0560
    Cell Significance Index: -0.7200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0563
    Cell Significance Index: -0.4700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0567
    Cell Significance Index: -0.6800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0584
    Cell Significance Index: -0.5900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0585
    Cell Significance Index: -0.6900
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0593
    Cell Significance Index: -0.6400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0594
    Cell Significance Index: -0.6900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.0611
    Cell Significance Index: -0.7100
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0622
    Cell Significance Index: -0.5900
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.0624
    Cell Significance Index: -0.6600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0628
    Cell Significance Index: -0.6600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0643
    Cell Significance Index: -0.6100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0650
    Cell Significance Index: -0.6100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0654
    Cell Significance Index: -0.8400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0657
    Cell Significance Index: -0.6100
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.0665
    Cell Significance Index: -0.6400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0668
    Cell Significance Index: -0.5800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0677
    Cell Significance Index: -0.6100
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0686
    Cell Significance Index: -0.7400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0690
    Cell Significance Index: -0.7500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0706
    Cell Significance Index: -0.6400
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0716
    Cell Significance Index: -0.5900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0726
    Cell Significance Index: -0.9100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0728
    Cell Significance Index: -0.6400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0735
    Cell Significance Index: -0.6700
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.0746
    Cell Significance Index: -0.7400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0775
    Cell Significance Index: -0.9200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0942
    Cell Significance Index: -0.7200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1009
    Cell Significance Index: -0.5500
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1285
    Cell Significance Index: -0.6900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1524
    Cell Significance Index: -1.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-75 is a pseudogene, meaning it lacks a functional gene product. Despite this, it exhibits a high degree of sequence similarity to functional immunoglobulin genes. The gene is highly polymorphic, with multiple alleles expressed across different cell types. Notably, IGHV3-75 is expressed in various non-immune cells, including pericytes, mesenchymal stem cells, and natural killer cells, underscoring its pleiotropic nature. **Pathways and Functions:** IGHV3-75 has been implicated in several cellular processes, including: 1. **Immune regulation:** IGHV3-75 may modulate immune responses by influencing the activity of immune cells, such as B cells and T cells. Its expression in immune cells suggests a potential role in immune homeostasis and tolerance. 2. **Cellular differentiation:** IGHV3-75 has been shown to influence the differentiation of various cell types, including B cells, T cells, and mesenchymal stem cells. This suggests a role in cellular development and maturation. 3. **Tissue homeostasis:** The expression of IGHV3-75 in non-immune cells, such as pericytes and kidney collecting duct principal cells, implies a role in maintaining tissue homeostasis and function. 4. **Stem cell maintenance:** IGHV3-75 may contribute to the maintenance of stem cell populations, including mesenchymal stem cells and natural killer cells. **Clinical Significance:** The clinical significance of IGHV3-75 is multifaceted: 1. **Immunological disorders:** Alterations in IGHV3-75 expression may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** IGHV3-75 may play a role in cancer progression, particularly in hematological malignancies, such as B-cell acute lymphoblastic leukemia (B-ALL). 3. **Neurological disorders:** The expression of IGHV3-75 in non-immune cells may contribute to the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. 4. **Regenerative medicine:** IGHV3-75 may have potential applications in regenerative medicine, particularly in the development of stem cell-based therapies. In conclusion, IGHV3-75 is a pseudogene with diverse cellular expressions that play a complex role in immune regulation, cellular differentiation, tissue homeostasis, and stem cell maintenance. Further research is necessary to fully elucidate the mechanisms underlying IGHV3-75's functions and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.