Details for: TRAJ33

Gene ID: 28722

Symbol: TRAJ33

Ensembl ID: ENSG00000211856

Description: T cell receptor alpha joining 33

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0151
    Cell Significance Index: 0.1900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0096
    Cell Significance Index: 0.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0022
    Cell Significance Index: 0.1100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0020
    Cell Significance Index: 0.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0050
    Cell Significance Index: -0.2200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0064
    Cell Significance Index: -0.0900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0070
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0080
    Cell Significance Index: -0.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0085
    Cell Significance Index: -0.3200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0089
    Cell Significance Index: -0.1000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0098
    Cell Significance Index: -0.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0124
    Cell Significance Index: -0.1400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0133
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0146
    Cell Significance Index: -0.1400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0153
    Cell Significance Index: -0.1500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0169
    Cell Significance Index: -0.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0174
    Cell Significance Index: -0.3200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0176
    Cell Significance Index: -0.2200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0189
    Cell Significance Index: -0.2000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0190
    Cell Significance Index: -0.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0202
    Cell Significance Index: -0.1100
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0214
    Cell Significance Index: -0.2700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0223
    Cell Significance Index: -0.2700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0228
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0232
    Cell Significance Index: -0.2200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0235
    Cell Significance Index: -0.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0237
    Cell Significance Index: -0.2800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0242
    Cell Significance Index: -0.2600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0243
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0253
    Cell Significance Index: -0.2700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0256
    Cell Significance Index: -0.2600
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0256
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0257
    Cell Significance Index: -0.2400
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0267
    Cell Significance Index: -0.3100
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0273
    Cell Significance Index: -0.2900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0284
    Cell Significance Index: -0.3300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0286
    Cell Significance Index: -0.2700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0298
    Cell Significance Index: -0.3200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0309
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0317
    Cell Significance Index: -0.3200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0318
    Cell Significance Index: -0.2800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0329
    Cell Significance Index: -0.3400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0330
    Cell Significance Index: -0.2900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0332
    Cell Significance Index: -0.3500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0337
    Cell Significance Index: -0.3400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0339
    Cell Significance Index: -0.2800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0345
    Cell Significance Index: -0.2900
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0348
    Cell Significance Index: -0.3100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0365
    Cell Significance Index: -0.3000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0366
    Cell Significance Index: -0.3200
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0373
    Cell Significance Index: -0.3400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0377
    Cell Significance Index: -0.2900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0385
    Cell Significance Index: -0.3200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0437
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The TRAJ33 gene is a non-coding RNA, specifically a microRNA (miRNA), which plays a crucial role in the post-transcriptional regulation of gene expression. Its expression is widespread, with significant levels detected in various immune cells, including B cells, T cells, and natural killer T cells. The TRAJ33 miRNA is known to target specific mRNAs, modulating the expression of genes involved in immune cell development, function, and survival. Notably, TRAJ33 is highly expressed in alpha-beta T cells, a subset of T cells that plays a central role in adaptive immunity. **Pathways and Functions:** The TRAJ33 gene is involved in multiple signaling pathways, including the Notch, T cell receptor (TCR), and interleukin-2 (IL-2) signaling pathways. These pathways are critical for the development, differentiation, and survival of immune cells. TRAJ33 modulates the expression of genes involved in these pathways, influencing the function of immune cells. Specifically, TRAJ33 has been shown to: * Regulate the expression of Notch ligands, influencing T cell development and differentiation. * Modulate the expression of TCR components, affecting T cell receptor signaling and function. * Inhibit the expression of IL-2, a cytokine essential for T cell proliferation and differentiation. **Clinical Significance:** The TRAJ33 gene has significant implications for the understanding and treatment of immune-related disorders. Dysregulation of TRAJ33 expression has been implicated in various autoimmune and inflammatory diseases, including: * Multiple sclerosis: TRAJ33 expression is altered in patients with multiple sclerosis, suggesting a potential role in disease pathogenesis. * Rheumatoid arthritis: TRAJ33 expression is also altered in patients with rheumatoid arthritis, highlighting its potential as a biomarker for disease diagnosis and progression. * Cancer: TRAJ33 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential as a therapeutic target. In conclusion, the TRAJ33 gene is a complex and multifaceted component of the immune system, playing a critical role in the development and function of various immune cells. Further research is needed to fully elucidate the mechanisms by which TRAJ33 regulates immune responses and to explore its therapeutic potential in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.