Details for: TRAJ10

Gene ID: 28745

Symbol: TRAJ10

Ensembl ID: ENSG00000211879

Description: T cell receptor alpha joining 10

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0537
    Cell Significance Index: 0.6900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0373
    Cell Significance Index: 0.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0238
    Cell Significance Index: 0.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.1000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0007
    Cell Significance Index: -0.1400
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0022
    Cell Significance Index: -0.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0027
    Cell Significance Index: -0.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0029
    Cell Significance Index: -0.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0034
    Cell Significance Index: -0.1300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0035
    Cell Significance Index: -0.0500
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0045
    Cell Significance Index: -0.0400
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0050
    Cell Significance Index: -0.0700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0051
    Cell Significance Index: -0.0400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0078
    Cell Significance Index: -0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0080
    Cell Significance Index: -0.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0082
    Cell Significance Index: -0.1600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0101
    Cell Significance Index: -0.1200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0118
    Cell Significance Index: -0.1400
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0120
    Cell Significance Index: -0.1500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0131
    Cell Significance Index: -0.1200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0134
    Cell Significance Index: -0.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0145
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0146
    Cell Significance Index: -0.1400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0149
    Cell Significance Index: -0.1800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0150
    Cell Significance Index: -0.1400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0151
    Cell Significance Index: -0.1300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0154
    Cell Significance Index: -0.1700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0155
    Cell Significance Index: -0.1800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0156
    Cell Significance Index: -0.1800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0156
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0163
    Cell Significance Index: -0.1700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0167
    Cell Significance Index: -0.1800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0168
    Cell Significance Index: -0.1700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0168
    Cell Significance Index: -0.1700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0170
    Cell Significance Index: -0.1900
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0172
    Cell Significance Index: -0.1900
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0175
    Cell Significance Index: -0.1800
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0176
    Cell Significance Index: -0.1600
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0179
    Cell Significance Index: -0.1600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0181
    Cell Significance Index: -0.1600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0189
    Cell Significance Index: -0.1900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0213
    Cell Significance Index: -0.1800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0217
    Cell Significance Index: -0.1900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0219
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0228
    Cell Significance Index: -0.1900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0234
    Cell Significance Index: -0.1900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0251
    Cell Significance Index: -0.2500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0257
    Cell Significance Index: -0.2000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0290
    Cell Significance Index: -0.2200
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0623
    Cell Significance Index: -0.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** TRAJ10 is expressed in a wide range of immune cells, including B cells, CD8-positive T cells, alpha-beta T cells, retinal rod cells, and innate lymphoid cells. Its expression is also observed in plasma cells, CD8-positive memory T cells, and naive thymus-derived CD4-positive T cells. 2. **Gene Structure:** The TRAJ10 gene consists of 12 exons and 11 introns, spanning a total length of approximately 15 kilobases. 3. **Gene Function:** TRAJ10 is involved in the regulation of immune cell development, function, and signaling. It is also believed to play a role in the modulation of immune responses and the maintenance of immune homeostasis. **Pathways and Functions:** 1. **Cell Signaling:** TRAJ10 is involved in the regulation of cell signaling pathways, including the T cell receptor (TCR) signaling pathway. It is thought to modulate the activation and proliferation of T cells in response to antigen presentation. 2. **Immune Cell Development:** TRAJ10 is essential for the development and maturation of various immune cells, including T cells, B cells, and innate lymphoid cells. It is also involved in the regulation of immune cell trafficking and homing. 3. **Immune Response Modulation:** TRAJ10 is believed to play a role in the modulation of immune responses, including the regulation of cytokine production and the activation of immune cells. **Clinical Significance:** 1. **Autoimmune Diseases:** Alterations in TRAJ10 expression have been implicated in various autoimmune diseases, including multiple sclerosis, type 1 diabetes, and rheumatoid arthritis. Understanding the role of TRAJ10 in these diseases may provide new insights into the development of therapeutic strategies. 2. **Cancer Immunotherapy:** TRAJ10 has been identified as a potential target for cancer immunotherapy. Its expression is altered in various types of cancer, and its dysregulation may contribute to the development of cancer. 3. **Infectious Diseases:** TRAJ10 is also involved in the regulation of immune responses to infections. Its dysregulation may contribute to the development of infectious diseases, such as tuberculosis and HIV. In conclusion, TRAJ10 is a complex gene that plays a critical role in the development, function, and regulation of various immune cells. Further research is needed to fully understand the mechanisms by which TRAJ10 regulates immune responses and to explore its potential as a therapeutic target in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.