Details for: TRAJ6

Gene ID: 28749

Symbol: TRAJ6

Ensembl ID: ENSG00000211883

Description: T cell receptor alpha joining 6

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.7320
    Cell Significance Index: 21.8800
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.1479
    Cell Significance Index: 1.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0310
    Cell Significance Index: 0.6800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0210
    Cell Significance Index: 0.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0014
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0030
    Cell Significance Index: -0.0500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0075
    Cell Significance Index: -0.1300
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0081
    Cell Significance Index: -0.1100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0092
    Cell Significance Index: -0.0500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0132
    Cell Significance Index: -0.1400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0136
    Cell Significance Index: -0.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0143
    Cell Significance Index: -0.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0160
    Cell Significance Index: -0.1800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0166
    Cell Significance Index: -0.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0174
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0179
    Cell Significance Index: -0.1700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0187
    Cell Significance Index: -0.2500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0192
    Cell Significance Index: -0.1800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0198
    Cell Significance Index: -0.2500
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0199
    Cell Significance Index: -0.2000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0201
    Cell Significance Index: -0.2400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0206
    Cell Significance Index: -0.2400
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0216
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0216
    Cell Significance Index: -0.2700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0217
    Cell Significance Index: -0.2300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0222
    Cell Significance Index: -0.2900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0222
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0230
    Cell Significance Index: -0.2200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0232
    Cell Significance Index: -0.2000
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0233
    Cell Significance Index: -0.2100
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0234
    Cell Significance Index: -0.2100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0237
    Cell Significance Index: -0.2000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0242
    Cell Significance Index: -0.2800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0243
    Cell Significance Index: -0.2800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0247
    Cell Significance Index: -0.2500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0249
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0257
    Cell Significance Index: -0.2600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0262
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0269
    Cell Significance Index: -0.2700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0270
    Cell Significance Index: -0.2100
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0274
    Cell Significance Index: -0.2900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0280
    Cell Significance Index: -0.2300
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0280
    Cell Significance Index: -0.2900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0284
    Cell Significance Index: -0.2800
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0285
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0285
    Cell Significance Index: -0.2600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0286
    Cell Significance Index: -0.2500
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0296
    Cell Significance Index: -0.2900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0320
    Cell Significance Index: -0.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0328
    Cell Significance Index: -0.3600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0329
    Cell Significance Index: -0.2800
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0344
    Cell Significance Index: -0.2900
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0363
    Cell Significance Index: -0.2500
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0390
    Cell Significance Index: -0.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ6 is a gene that encodes a protein with a unique structure, consisting of a central domain and two N-terminal domains. The central domain is responsible for interacting with the T cell receptor (TCR) complex, while the N-terminal domains are involved in protein-protein interactions. TRAJ6 is highly conserved across different species, suggesting its essential role in T cell development and function. The gene is significantly expressed in various T cell subsets, including CD8-positive and CD4-positive T cells, and is also found in other immune cells, such as NK T cells and thymocytes. **Pathways and Functions:** TRAJ6 plays a crucial role in T cell development and function by interacting with the TCR complex. The central domain of TRAJ6 binds to the TCR, facilitating the assembly and activation of the TCR complex. This interaction is essential for the proper functioning of T cells, as it allows them to recognize and respond to antigens. TRAJ6 also participates in the regulation of T cell activation and proliferation, influencing the development of immune responses. Additionally, TRAJ6 has been implicated in the regulation of T cell homeostasis, ensuring the proper balance between T cell activation and tolerance. **Clinical Significance:** Dysregulation of TRAJ6 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. T cell dysfunction and dysregulation are common features of these diseases, and TRAJ6 plays a crucial role in maintaining T cell homeostasis and function. For example, mutations in TRAJ6 have been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where T cell dysfunction and dysregulation contribute to disease pathogenesis. Furthermore, TRAJ6 has been implicated in the development of cancer, where T cell dysfunction and dysregulation can contribute to tumor progression and immune evasion. Understanding the functions and significance of TRAJ6 is essential for developing novel therapeutic strategies to target T cell dysfunction and dysregulation in these diseases. In conclusion, TRAJ6 is a gene that plays a crucial role in T cell development and function, and its dysregulation has been implicated in various immune-related disorders. Further research is needed to fully elucidate the functions and significance of TRAJ6, but its importance in maintaining T cell homeostasis and function cannot be overstated.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.