Details for: IFNA8

Gene ID: 3445

Symbol: IFNA8

Ensembl ID: ENSG00000120242

Description: interferon alpha 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.7570
    Cell Significance Index: 7.1900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1690
    Cell Significance Index: 2.7400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.1169
    Cell Significance Index: 1.4000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0900
    Cell Significance Index: 0.5300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0272
    Cell Significance Index: 0.2700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0150
    Cell Significance Index: 0.2000
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.0080
    Cell Significance Index: 0.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0017
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0038
    Cell Significance Index: -0.7600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0080
    Cell Significance Index: -0.1100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0084
    Cell Significance Index: -0.1000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0086
    Cell Significance Index: -0.0900
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0091
    Cell Significance Index: -0.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0101
    Cell Significance Index: -0.1400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0102
    Cell Significance Index: -0.2000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0160
    Cell Significance Index: -0.1100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0224
    Cell Significance Index: -0.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0233
    Cell Significance Index: -0.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0233
    Cell Significance Index: -0.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0245
    Cell Significance Index: -0.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0254
    Cell Significance Index: -0.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0282
    Cell Significance Index: -0.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0341
    Cell Significance Index: -0.8500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0341
    Cell Significance Index: -0.3900
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.0347
    Cell Significance Index: -0.3400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0388
    Cell Significance Index: -0.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0389
    Cell Significance Index: -0.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0405
    Cell Significance Index: -0.8600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0416
    Cell Significance Index: -0.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0433
    Cell Significance Index: -0.8700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0451
    Cell Significance Index: -0.8900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0492
    Cell Significance Index: -0.6600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0535
    Cell Significance Index: -0.7000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0623
    Cell Significance Index: -0.7500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0639
    Cell Significance Index: -0.6900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0649
    Cell Significance Index: -0.8900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0686
    Cell Significance Index: -0.7200
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0711
    Cell Significance Index: -0.7500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0734
    Cell Significance Index: -0.8300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0744
    Cell Significance Index: -0.8500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0760
    Cell Significance Index: -0.9000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0761
    Cell Significance Index: -1.0000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0784
    Cell Significance Index: -0.9700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0799
    Cell Significance Index: -0.8700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0829
    Cell Significance Index: -0.9800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0833
    Cell Significance Index: -0.8500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0833
    Cell Significance Index: -1.0200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0837
    Cell Significance Index: -0.8900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0862
    Cell Significance Index: -0.8200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0865
    Cell Significance Index: -0.8200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0882
    Cell Significance Index: -0.9800
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1166
    Cell Significance Index: -1.0300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1503
    Cell Significance Index: -0.8000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2110
    Cell Significance Index: -1.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFNA8 is a type I interferon, which is a key player in the innate immune response against viral infections. It is produced by various cells, including goblet cells, neoplastic cells, and intestinal epithelial cells, and is involved in the regulation of immune cell activation, cytokine signaling, and viral replication. IFNA8 is structurally similar to other interferons, with a conserved alpha-helix region that is essential for its biological activity. **Pathways and Functions:** IFNA8 is involved in several key pathways, including the adaptive immune response, B cell differentiation, and cellular response to virus. It acts through the interferon alpha/beta receptor, which triggers a signaling cascade that leads to the activation of transcription factors, such as interferon regulatory factor 7 (IRF7) and interferon-stimulated gene factor 3 (ISGF3). This results in the expression of interferon-stimulated genes (ISGs), which are involved in the regulation of viral replication and immune cell activation. IFNA8 also plays a role in the regulation of cytokine signaling, including the activation of natural killer cells and the regulation of T cell activation. Additionally, IFNA8 is involved in the modulation of viral replication, including the regulation of respiratory syncytial virus (RSV) and SARS-CoV-2 infections. **Clinical Significance:** IFNA8 has significant clinical implications in the context of viral infections and immune-related diseases. Its dysregulation has been implicated in various diseases, including respiratory syncytial virus (RSV) and SARS-CoV-2 infections, as well as autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. Furthermore, IFNA8 has been explored as a potential therapeutic agent in the treatment of viral infections, including RSV and SARS-CoV-2 infections. Its ability to modulate immune cell activation and regulate viral replication makes it an attractive candidate for the development of novel antiviral therapies. In conclusion, IFNA8 is a critical component of the innate immune response, playing a pivotal role in the defense against viral infections. Its dysregulation has significant clinical implications, and its potential as a therapeutic agent makes it an area of active research. Further studies are needed to fully elucidate the functions and pathways of IFNA8, as well as its clinical significance in the context of viral infections and immune-related diseases. **References:** 1. [Insert references to relevant studies and reviews on IFNA8] 2. [Insert references to relevant reviews on interferon alpha/beta signaling and immune-related diseases] Note: The references provided are hypothetical and should be replaced with actual references to relevant studies and reviews on IFNA8 and interferon alpha/beta signaling.

Genular Protein ID: 761921728

Symbol: IFNA8_HUMAN

Name: Interferon alpha-8

UniProtKB Accession Codes:

P32881 P01565 P09236 Q5VWV7 Q5VYQ3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 2 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 6325303

Title: Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes.

PubMed ID: 6325303

DOI: 10.1016/0378-1119(84)90241-5

PubMed ID: 6164048

Title: Bacterial synthesis of a novel human leukocyte interferon.

PubMed ID: 6164048

DOI: 10.1093/nar/9.3.731

PubMed ID: 6163083

Title: The structure of eight distinct cloned human leukocyte interferon cDNAs.

PubMed ID: 6163083

DOI: 10.1038/290020a0

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 8836918

Title: Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population.

PubMed ID: 8836918

DOI: 10.1089/jir.1996.16.523

Sequence Information:

  • Length: 189
  • Mass: 21989
  • Checksum: 83128DA2B6DBB2C1
  • Sequence:
    • MALTFYLLVA LVVLSYKSFS SLGCDLPQTH SLGNRRALIL LAQMRRISPF SCLKDRHDFE 
FPQEEFDDKQ FQKAQAISVL HEMIQQTFNL FSTKDSSAAL DETLLDEFYI ELDQQLNDLE 
SCVMQEVGVI ESPLMYEDSI LAVRKYFQRI TLYLTEKKYS SCAWEVVRAE IMRSFSLSIN 
LQKRLKSKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.