Details for: MIR219A1

Gene ID: 407002

Symbol: MIR219A1

Ensembl ID: ENSG00000199036

Description: microRNA 219a-1

Associated with

  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of neuron projection development
    (GO:0010977)
  • Negative regulation of peptidyl-serine phosphorylation
    (GO:0033137)
  • Negative regulation of tau-protein kinase activity
    (GO:1902948)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2658
    Cell Significance Index: 3.7800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1107
    Cell Significance Index: 1.1700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0921
    Cell Significance Index: 1.4600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0574
    Cell Significance Index: 0.8000
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0521
    Cell Significance Index: 0.6200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0458
    Cell Significance Index: 0.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0269
    Cell Significance Index: 0.7800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.0185
    Cell Significance Index: 0.2000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0128
    Cell Significance Index: 0.1200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0105
    Cell Significance Index: 0.1800
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0042
    Cell Significance Index: 0.0500
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0003
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0030
    Cell Significance Index: -0.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0048
    Cell Significance Index: -0.9600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0058
    Cell Significance Index: -0.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0079
    Cell Significance Index: -0.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0086
    Cell Significance Index: -0.1900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0111
    Cell Significance Index: -0.1200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0147
    Cell Significance Index: -0.1500
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0152
    Cell Significance Index: -0.1300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0159
    Cell Significance Index: -0.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0200
    Cell Significance Index: -0.5400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0243
    Cell Significance Index: -0.2400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0284
    Cell Significance Index: -0.2500
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0289
    Cell Significance Index: -0.3200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0293
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0331
    Cell Significance Index: -0.3100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0355
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0364
    Cell Significance Index: -0.3700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0370
    Cell Significance Index: -0.4300
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0428
    Cell Significance Index: -0.3900
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0448
    Cell Significance Index: -0.5000
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0453
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0456
    Cell Significance Index: -0.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0467
    Cell Significance Index: -0.9400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0470
    Cell Significance Index: -0.4800
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0473
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0475
    Cell Significance Index: -0.4500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0485
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0488
    Cell Significance Index: -0.4700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0517
    Cell Significance Index: -0.8900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0526
    Cell Significance Index: -0.4900
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0555
    Cell Significance Index: -0.5100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0765
    Cell Significance Index: -0.5000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0771
    Cell Significance Index: -0.9100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0812
    Cell Significance Index: -0.7700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1162
    Cell Significance Index: -0.7300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1247
    Cell Significance Index: -0.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR219A1 is a microRNA, a class of small non-coding RNAs that regulate gene expression by binding to messenger RNA (mRNA) targets, leading to their degradation or suppression of translation. This microRNA is part of the RISC complex, a key regulatory machinery for microRNA-mediated post-transcriptional gene silencing. MIR219A1 is specifically expressed in neuronal receptor cells, smooth muscle myoblasts, and immune cells, suggesting its involvement in the development and function of these cell types. **Pathways and Functions:** MIR219A1 has been implicated in several cellular processes, including: 1. **Negative regulation of neuron projection development**: MIR219A1 has been shown to inhibit the expression of genes involved in axon guidance and neuronal projection development, highlighting its role in regulating neuronal development and function. 2. **Negative regulation of peptidyl-serine phosphorylation**: MIR219A1 has been shown to inhibit the expression of enzymes involved in peptidyl-serine phosphorylation, a process critical for protein function and signaling. 3. **Negative regulation of tau-protein kinase activity**: MIR219A1 has been implicated in regulating tau-protein kinase activity, a process involved in neuronal development and function. 4. **Immune responses**: MIR219A1 has been shown to regulate immune responses by modulating the expression of genes involved in immune cell development and function. **Clinical Significance:** The dysregulation of MIR219A1 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Altered expression of MIR219A1 has been linked to neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. 2. **Immune-related disorders**: MIR219A1 has been implicated in immune-related disorders, including autoimmune diseases and cancer. 3. **Cancer**: MIR219A1 has been shown to regulate gene expression in cancer cells, highlighting its potential as a therapeutic target. In conclusion, MIR219A1 is a critical regulator of gene expression in various cell types, including neuronal receptor cells, smooth muscle myoblasts, and immune cells. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of MIR219A1 and its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.