Details for: RNU5E 9P

Gene ID: 100873840

Symbol: RNU5E 9P

Ensembl ID: ENSG00000223096

Description: RNA, U5E small nuclear 9, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1963
    Cell Significance Index: 1.6200
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1314
    Cell Significance Index: 1.5800
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.0378
    Cell Significance Index: 0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0008
    Cell Significance Index: 0.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0005
    Cell Significance Index: -0.1300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0033
    Cell Significance Index: -0.0800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0039
    Cell Significance Index: -0.1300
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0044
    Cell Significance Index: -0.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0048
    Cell Significance Index: -0.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0052
    Cell Significance Index: -0.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0056
    Cell Significance Index: -0.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0060
    Cell Significance Index: -0.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0061
    Cell Significance Index: -0.1300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0073
    Cell Significance Index: -0.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0084
    Cell Significance Index: -0.1000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0095
    Cell Significance Index: -0.1200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0096
    Cell Significance Index: -0.1400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0100
    Cell Significance Index: -0.1300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0108
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0114
    Cell Significance Index: -0.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0115
    Cell Significance Index: -0.1400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0116
    Cell Significance Index: -0.1100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0118
    Cell Significance Index: -0.1400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0122
    Cell Significance Index: -0.1600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0125
    Cell Significance Index: -0.1400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0126
    Cell Significance Index: -0.1400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0129
    Cell Significance Index: -0.1200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0137
    Cell Significance Index: -0.1500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0139
    Cell Significance Index: -0.1300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0143
    Cell Significance Index: -0.1300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0145
    Cell Significance Index: -0.0800
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0148
    Cell Significance Index: -0.1300
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0154
    Cell Significance Index: -0.1600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0158
    Cell Significance Index: -0.1800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0172
    Cell Significance Index: -0.1500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0175
    Cell Significance Index: -0.2100
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0187
    Cell Significance Index: -0.1300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0200
    Cell Significance Index: -0.1300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0219
    Cell Significance Index: -0.1300
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0269
    Cell Significance Index: -0.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU5E 9P is a pseudogene, which means it lacks the ability to encode a functional protein. Despite its non-coding nature, RNU5E 9P is significantly expressed in various cell types, including those involved in immune responses, neuronal development, and epithelial homeostasis. The expression of RNU5E 9P is not limited to specific tissues; it is also detected in abnormal and neoplastic cells, suggesting a potential role in cancer development or progression. **Pathways and Functions:** The functional mechanisms of RNU5E 9P are not fully understood, but several pathways have been implicated in its regulation. These include: 1. **RNA processing and splicing**: RNU5E 9P may influence RNA processing and splicing, potentially affecting the expression of nearby genes. 2. **Epigenetic regulation**: RNU5E 9P may interact with epigenetic regulators, such as histone-modifying enzymes, to modulate gene expression. 3. **Non-coding RNA-mediated regulation**: RNU5E 9P may interact with other non-coding RNAs, such as microRNAs or long non-coding RNAs, to regulate gene expression. While the exact functions of RNU5E 9P are unclear, its widespread expression suggests that it may play a role in maintaining cellular homeostasis, particularly in epithelial tissues. **Clinical Significance:** RNU5E 9P has been detected in various types of cancer, including colorectal, lung, and breast cancer. Its expression in neoplastic cells raises questions about its potential role in cancer development or progression. Furthermore, RNU5E 9P is also expressed in abnormal and stem cells, suggesting a potential link to cancer stem cell maintenance. In addition to its potential role in cancer, RNU5E 9P may also be involved in other diseases, such as: 1. **Neurological disorders**: RNU5E 9P is expressed in oligodendrocyte precursor cells, which are involved in the development of the central nervous system. 2. **Gastrointestinal disorders**: RNU5E 9P is expressed in intestinal enteroendocrine cells, which are involved in regulating gastrointestinal function. In conclusion, RNU5E 9P is a complex pseudogene that exhibits widespread expression across various cell types. While its functional mechanisms are not fully understood, its potential role in cancer development, neurological disorders, and gastrointestinal disorders makes it an intriguing area of research. Further studies are necessary to elucidate the biological significance of RNU5E 9P and its potential applications in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.