Details for: OR8B2

Gene ID: 26595

Symbol: OR8B2

Ensembl ID: ENSG00000284680

Description: olfactory receptor family 8 subfamily B member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 6.9419
    Cell Significance Index: 118.6600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 3.4686
    Cell Significance Index: 44.8800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 3.0961
    Cell Significance Index: 78.8800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.5548
    Cell Significance Index: 35.0300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.1847
    Cell Significance Index: 35.3800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 1.7774
    Cell Significance Index: 18.8800
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4435
    Cell Significance Index: 5.8200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.3962
    Cell Significance Index: 5.7500
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0118
    Cell Significance Index: 0.1300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0109
    Cell Significance Index: 0.1300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0036
    Cell Significance Index: -0.1200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0041
    Cell Significance Index: -0.0700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0049
    Cell Significance Index: -0.0300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0084
    Cell Significance Index: -0.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0084
    Cell Significance Index: -0.1600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0085
    Cell Significance Index: -0.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0088
    Cell Significance Index: -0.0800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0104
    Cell Significance Index: -0.1500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0105
    Cell Significance Index: -0.1000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0123
    Cell Significance Index: -0.1100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0124
    Cell Significance Index: -0.1500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0125
    Cell Significance Index: -0.1600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0131
    Cell Significance Index: -0.0700
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0131
    Cell Significance Index: -0.1400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0132
    Cell Significance Index: -0.1200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0133
    Cell Significance Index: -0.1800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0135
    Cell Significance Index: -0.1200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0138
    Cell Significance Index: -0.1400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0138
    Cell Significance Index: -0.0900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0140
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0141
    Cell Significance Index: -0.1200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0145
    Cell Significance Index: -0.0900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0177
    Cell Significance Index: -0.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0179
    Cell Significance Index: -0.1500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0246
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0250
    Cell Significance Index: -0.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0281
    Cell Significance Index: -0.1700
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0482
    Cell Significance Index: -0.5200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0522
    Cell Significance Index: -0.5000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0699
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0700
    Cell Significance Index: -0.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1436
    Cell Significance Index: -4.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3050
    Cell Significance Index: -5.1400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4773
    Cell Significance Index: -4.8700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.5086
    Cell Significance Index: -5.0200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.6261
    Cell Significance Index: -4.8700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.9303
    Cell Significance Index: -5.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR8B2 is a G protein-coupled receptor (GPCR) that is activated by odorant molecules, leading to the initiation of signaling cascades that ultimately result in the perception of smell. Unlike traditional olfactory receptors, OR8B2 exhibits a unique ligand-binding profile, with a preference for certain odorant molecules. OR8B2 is also expressed in non-neuronal cells, such as hematopoietic stem cells and erythrocytes, suggesting a broader role in immune function. **Pathways and Functions:** OR8B2 belongs to the G protein-coupled receptor signaling pathway, which involves the activation of G proteins and the subsequent modulation of downstream signaling molecules. Upon activation by odorant molecules, OR8B2 triggers a signaling cascade that involves the activation of adenylyl cyclase, leading to an increase in cAMP levels. This increase in cAMP levels activates protein kinase A (PKA), which in turn modulates various cellular processes, including gene expression and cell proliferation. In addition to its role in sensory perception, OR8B2 has been implicated in modulating immune responses. Studies have shown that OR8B2 is expressed in hematopoietic stem cells, where it plays a crucial role in regulating the development of immune cells. OR8B2 has also been shown to influence the function of innate immune cells, such as pericytes and smooth muscle myoblasts, which are involved in the regulation of inflammation and immune responses. **Clinical Significance:** OR8B2 has been implicated in various immune-related disorders, including autoimmune diseases and cancer. For example, studies have shown that OR8B2 is overexpressed in patients with multiple sclerosis, a disease characterized by autoimmune inflammation in the central nervous system. Additionally, OR8B2 has been shown to be involved in the development of certain types of cancer, including leukemia and lymphoma. Furthermore, OR8B2 has been proposed as a potential therapeutic target for the treatment of immune-related disorders. For example, small-molecule inhibitors of OR8B2 have been shown to modulate immune responses and reduce inflammation in animal models of autoimmune disease. These findings suggest that OR8B2 may be a valuable target for the development of novel immunotherapies. In conclusion, OR8B2 is a multifunctional receptor that plays a crucial role in both sensory perception and immune function. Its unique ligand-binding profile and expression in non-neuronal cells make it an attractive target for the treatment of immune-related disorders. Further studies are needed to fully elucidate the functions of OR8B2 and its potential as a therapeutic target.

Genular Protein ID: 2456662725

Symbol: OR8B2_HUMAN

Name: Olfactory receptor 8B2

UniProtKB Accession Codes:

Q96RD0 Q8NGH2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 12213199

Title: DEFOG: a practical scheme for deciphering families of genes.

PubMed ID: 12213199

DOI: 10.1006/geno.2002.6830

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 313
  • Mass: 35272
  • Checksum: 6FA6C2FC8DD4BE5F
  • Sequence:
    • MLARNNSLVT EFILAGLTDH PEFRQPLFFL FLVIYIVTMV GNLGLITLFG LNSHLHTPMY 
YFLFNLSFID LCYSSVFTPK MLMNFVSKKN IISNVGCMTR LFFFLFFVIS ECYMLTSMAY 
DRYVAICNPL LYKVTMSHQV CSMLTFAAYI MGLAGATAHT GCMLRLTFCS ANIINHYLCD 
ILPLLQLSCT STYVNEVVVL IVVGTNITVP SCTILISYVF IVTSILHIKS TQGRSKAFST 
CSSHVIALSL FFGSAAFMYI KYSSGSMEQG KVSSVFYTNV VPMLNPLIYS LRNKDVKVAL 
RKALIKIQRR NIF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.