Details for: SNORD42B

Gene ID: 26808

Symbol: SNORD42B

Ensembl ID: ENSG00000238423

Description: small nucleolar RNA, C/D box 42B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.4633
    Cell Significance Index: 5.3800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.1233
    Cell Significance Index: 1.2200
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0277
    Cell Significance Index: 0.3300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0196
    Cell Significance Index: 0.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0141
    Cell Significance Index: 0.7300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0075
    Cell Significance Index: -0.0800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0104
    Cell Significance Index: -0.1800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0117
    Cell Significance Index: -0.1300
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0134
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0141
    Cell Significance Index: -0.1300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0159
    Cell Significance Index: -0.1500
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0209
    Cell Significance Index: -0.1600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0442
    Cell Significance Index: -0.4500
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0482
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0874
    Cell Significance Index: -0.9200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0899
    Cell Significance Index: -0.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1003
    Cell Significance Index: -5.2300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1631
    Cell Significance Index: -4.3700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1635
    Cell Significance Index: -1.9300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1983
    Cell Significance Index: -1.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2599
    Cell Significance Index: -5.6900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2937
    Cell Significance Index: -4.9400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3425
    Cell Significance Index: -4.7500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.3520
    Cell Significance Index: -4.1600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.4388
    Cell Significance Index: -4.1600
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4396
    Cell Significance Index: -5.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4401
    Cell Significance Index: -4.8000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.4591
    Cell Significance Index: -5.7500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4604
    Cell Significance Index: -5.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4647
    Cell Significance Index: -5.5400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.4659
    Cell Significance Index: -5.5600
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4662
    Cell Significance Index: -5.8200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.4836
    Cell Significance Index: -4.9300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.4967
    Cell Significance Index: -5.8400
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.5107
    Cell Significance Index: -5.6800
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.5130
    Cell Significance Index: -5.6200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.5134
    Cell Significance Index: -5.0700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.5220
    Cell Significance Index: -6.5500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.5241
    Cell Significance Index: -7.0700
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.5285
    Cell Significance Index: -5.9700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.5338
    Cell Significance Index: -6.4700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.5353
    Cell Significance Index: -6.5800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.5487
    Cell Significance Index: -6.5800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.5819
    Cell Significance Index: -7.6000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.5901
    Cell Significance Index: -5.4200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.6075
    Cell Significance Index: -5.0300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.6573
    Cell Significance Index: -5.7900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6610
    Cell Significance Index: -7.5700
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.6649
    Cell Significance Index: -7.6000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.7070
    Cell Significance Index: -7.5800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7935
    Cell Significance Index: -6.5500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.8013
    Cell Significance Index: -6.1700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -1.0907
    Cell Significance Index: -7.5700
  • Cell Name: basket cell (CL0000118)
    Fold Change: -1.6729
    Cell Significance Index: -8.0700
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -2.4424
    Cell Significance Index: -5.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD42B is a small nucleolar RNA, approximately 72 nucleotides in length, belonging to the C/D box family of snoRNAs. These snoRNAs play a crucial role in RNA processing, particularly in the modification of ribosomal RNA (rRNA) and other small RNAs. SNORD42B is specifically localized to the nucleolus, a region within the nucleus responsible for ribosome biogenesis and rRNA processing. **Pathways and Functions:** The exact mechanisms by which SNORD42B regulates RNA processing and cellular differentiation are not yet fully elucidated. However, several key pathways and functions have been identified: 1. **Ribosome biogenesis:** SNORD42B is thought to participate in the regulation of ribosome biogenesis, influencing the production of rRNA and, subsequently, the assembly of ribosomes. 2. **RNA processing:** SNORD42B may also be involved in the processing of other small RNAs, such as microRNAs (miRNAs) and small interfering RNAs (siRNAs), which play critical roles in regulating gene expression. 3. **Cellular differentiation:** SNORD42B expression has been linked to the differentiation of various cell types, including pericytes, cardiac endothelial cells, and immune cells. This suggests that SNORD42B may play a role in regulating cellular fate and promoting specific cell types. **Clinical Significance:** While the functional significance of SNORD42B is still unclear, its expression in various cell types and tissues raises several potential clinical implications: 1. **Cancer:** Alterations in SNORD42B expression have been observed in certain types of cancer, suggesting that this snoRNA may serve as a biomarker for cancer diagnosis or a target for therapeutic intervention. 2. **Cardiovascular disease:** SNORD42B expression in cardiac cells suggests that this snoRNA may play a role in the development or progression of cardiovascular disease. 3. **Neurological disorders:** The expression of SNORD42B in neuronal cells raises the possibility that this snoRNA may be involved in neurological disorders, such as Alzheimer's disease or Parkinson's disease. In conclusion, SNORD42B is a small nucleolar RNA with significant expression in various cell types and tissues. While the exact mechanisms by which this snoRNA regulates RNA processing and cellular differentiation are still unclear, its clinical implications are promising. Further research is necessary to fully elucidate the role of SNORD42B in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.