Details for: TRBJ1 4

Gene ID: 28632

Symbol: TRBJ1 4

Ensembl ID: ENSG00000281958

Description: T cell receptor beta joining 1-4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 8.8718
    Cell Significance Index: 173.4600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.7319
    Cell Significance Index: 41.9500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6765
    Cell Significance Index: 9.8600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3829
    Cell Significance Index: 5.0300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.1119
    Cell Significance Index: 0.6100
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0532
    Cell Significance Index: 0.5700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0213
    Cell Significance Index: 0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0021
    Cell Significance Index: -0.4200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0052
    Cell Significance Index: -0.0900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0069
    Cell Significance Index: -0.0900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0125
    Cell Significance Index: -0.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0179
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0185
    Cell Significance Index: -0.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0189
    Cell Significance Index: -0.3500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0195
    Cell Significance Index: -0.2300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0199
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0221
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0235
    Cell Significance Index: -0.2200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0271
    Cell Significance Index: -0.3200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0271
    Cell Significance Index: -0.3000
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0291
    Cell Significance Index: -0.3400
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0329
    Cell Significance Index: -0.2700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0360
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0375
    Cell Significance Index: -0.3600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0383
    Cell Significance Index: -0.4200
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0415
    Cell Significance Index: -0.3600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0421
    Cell Significance Index: -0.3600
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0448
    Cell Significance Index: -0.4100
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0478
    Cell Significance Index: -0.5500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0492
    Cell Significance Index: -0.4600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0511
    Cell Significance Index: -0.5700
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0514
    Cell Significance Index: -0.4800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0518
    Cell Significance Index: -0.4400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0535
    Cell Significance Index: -0.4800
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0542
    Cell Significance Index: -0.5000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0546
    Cell Significance Index: -0.5700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0567
    Cell Significance Index: -0.5800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0574
    Cell Significance Index: -0.6600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0583
    Cell Significance Index: -0.6200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0596
    Cell Significance Index: -0.5000
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0599
    Cell Significance Index: -0.5600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0602
    Cell Significance Index: -0.5000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0610
    Cell Significance Index: -0.6200
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0635
    Cell Significance Index: -0.6400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0650
    Cell Significance Index: -0.6600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0673
    Cell Significance Index: -0.6800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0695
    Cell Significance Index: -0.8000
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0703
    Cell Significance Index: -0.5700
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0718
    Cell Significance Index: -0.4900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0753
    Cell Significance Index: -0.6500
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0793
    Cell Significance Index: -0.9200
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0827
    Cell Significance Index: -0.6700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0874
    Cell Significance Index: -0.6800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0903
    Cell Significance Index: -0.7900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0942
    Cell Significance Index: -0.9400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0981
    Cell Significance Index: -0.7300
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1067
    Cell Significance Index: -0.5700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2953
    Cell Significance Index: -0.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBJ1.4 is a member of the T cell receptor beta (TRB) family, which is responsible for recognizing and binding to antigens presented by major histocompatibility complex (MHC) molecules. The TRB family is composed of 24 alpha chains and 16 beta chains, which combine to form a TCR complex. TRBJ1.4 is a beta chain that interacts with alpha chains to form a functional TCR. The diversity of TRBJ1.4 is achieved through the random combination of alpha and beta chains during T cell development in the thymus. **Pathways and Functions:** TRBJ1.4 is involved in the adaptive immune response through several key pathways: 1. **TCR signaling**: TRBJ1.4 plays a crucial role in TCR signaling, which is essential for the activation and proliferation of T cells in response to antigen presentation. 2. **MHC binding**: TRBJ1.4 interacts with MHC molecules to facilitate antigen recognition and presentation to T cells. 3. **T cell development**: TRBJ1.4 is involved in the development and maturation of T cells in the thymus, where it helps to select and eliminate T cells with aberrant TCR repertoires. 4. **Immune regulation**: TRBJ1.4 may also contribute to immune regulation by modulating the activity of T cells and other immune cells. **Clinical Significance:** Dysregulation of TRBJ1.4 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: Alterations in TRBJ1.4 expression or function may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: TRBJ1.4 may play a role in the immune evasion of cancer cells, allowing them to evade T cell recognition and destruction. 3. **Infectious diseases**: TRBJ1.4 may be involved in the immune response to infectious diseases, such as HIV and tuberculosis. 4. **Transplantation**: TRBJ1.4 may also be relevant to transplantation medicine, where immune tolerance and rejection of transplanted organs are critical concerns. In conclusion, TRBJ1.4 is a critical component of the adaptive immune response, and its dysregulation may contribute to various immune-related disorders. Further research is needed to fully understand the role of TRBJ1.4 in immune function and to explore its potential as a therapeutic target for immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.