Details for: TRBJ1 4

Gene ID: 28632

Symbol: TRBJ1 4

Ensembl ID: ENSG00000281958

Description: T cell receptor beta joining 1-4

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.38
    Marker Score: 492
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.12
    Marker Score: 239
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.05
    Marker Score: 166
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.03
    Marker Score: 1,724
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.02
    Marker Score: 52
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.02
    Marker Score: 15
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 18
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 8
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 22
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 6

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRBJ1.4 is a member of the T cell receptor beta (TRB) family, which is responsible for recognizing and binding to antigens presented by major histocompatibility complex (MHC) molecules. The TRB family is composed of 24 alpha chains and 16 beta chains, which combine to form a TCR complex. TRBJ1.4 is a beta chain that interacts with alpha chains to form a functional TCR. The diversity of TRBJ1.4 is achieved through the random combination of alpha and beta chains during T cell development in the thymus. **Pathways and Functions:** TRBJ1.4 is involved in the adaptive immune response through several key pathways: 1. **TCR signaling**: TRBJ1.4 plays a crucial role in TCR signaling, which is essential for the activation and proliferation of T cells in response to antigen presentation. 2. **MHC binding**: TRBJ1.4 interacts with MHC molecules to facilitate antigen recognition and presentation to T cells. 3. **T cell development**: TRBJ1.4 is involved in the development and maturation of T cells in the thymus, where it helps to select and eliminate T cells with aberrant TCR repertoires. 4. **Immune regulation**: TRBJ1.4 may also contribute to immune regulation by modulating the activity of T cells and other immune cells. **Clinical Significance:** Dysregulation of TRBJ1.4 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: Alterations in TRBJ1.4 expression or function may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: TRBJ1.4 may play a role in the immune evasion of cancer cells, allowing them to evade T cell recognition and destruction. 3. **Infectious diseases**: TRBJ1.4 may be involved in the immune response to infectious diseases, such as HIV and tuberculosis. 4. **Transplantation**: TRBJ1.4 may also be relevant to transplantation medicine, where immune tolerance and rejection of transplanted organs are critical concerns. In conclusion, TRBJ1.4 is a critical component of the adaptive immune response, and its dysregulation may contribute to various immune-related disorders. Further research is needed to fully understand the role of TRBJ1.4 in immune function and to explore its potential as a therapeutic target for immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.