Details for: TRBJ1 3

Gene ID: 28633

Symbol: TRBJ1 3

Ensembl ID: ENSG00000282133

Description: T cell receptor beta joining 1-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 6.8971
    Cell Significance Index: 134.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1502
    Cell Significance Index: 27.8600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4281
    Cell Significance Index: 6.2400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3677
    Cell Significance Index: 4.8300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0495
    Cell Significance Index: 0.2700
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.0072
    Cell Significance Index: 0.0800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0012
    Cell Significance Index: -0.2400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0025
    Cell Significance Index: -0.0400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0071
    Cell Significance Index: -0.0900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0130
    Cell Significance Index: -0.2100
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0144
    Cell Significance Index: -0.1700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0167
    Cell Significance Index: -0.2900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0168
    Cell Significance Index: -0.3100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0169
    Cell Significance Index: -0.2000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0181
    Cell Significance Index: -0.2000
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0216
    Cell Significance Index: -0.2300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0237
    Cell Significance Index: -0.2600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0246
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0247
    Cell Significance Index: -0.2300
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0256
    Cell Significance Index: -0.2100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0261
    Cell Significance Index: -0.2200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0267
    Cell Significance Index: -0.2800
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0273
    Cell Significance Index: -0.2800
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0275
    Cell Significance Index: -0.3100
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0277
    Cell Significance Index: -0.3100
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0286
    Cell Significance Index: -0.2900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0291
    Cell Significance Index: -0.3900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0306
    Cell Significance Index: -0.3100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0321
    Cell Significance Index: -0.3000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0326
    Cell Significance Index: -0.3100
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0335
    Cell Significance Index: -0.3100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0337
    Cell Significance Index: -0.3400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0337
    Cell Significance Index: -0.3000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0354
    Cell Significance Index: -0.3100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0363
    Cell Significance Index: -0.3700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0367
    Cell Significance Index: -0.2900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0388
    Cell Significance Index: -0.4100
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0431
    Cell Significance Index: -0.5000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0433
    Cell Significance Index: -0.3700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0445
    Cell Significance Index: -0.3400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0452
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0465
    Cell Significance Index: -0.4700
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0475
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0531
    Cell Significance Index: -0.5100
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0545
    Cell Significance Index: -0.4700
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0563
    Cell Significance Index: -0.5200
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0592
    Cell Significance Index: -0.5000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0611
    Cell Significance Index: -0.6100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0642
    Cell Significance Index: -0.5200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0668
    Cell Significance Index: -0.5200
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0669
    Cell Significance Index: -0.7700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0699
    Cell Significance Index: -0.5200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0730
    Cell Significance Index: -0.3900
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.0909
    Cell Significance Index: -0.7600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1134
    Cell Significance Index: -0.7800
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2707
    Cell Significance Index: -0.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** TRBJ1 is a small peptide that joins the TCR alpha chain to form a functional TCR heterodimer. 2. **Expression:** TRBJ1 is significantly expressed in CD8-positive, alpha-beta T cells, natural killer cells, and B cells, among other immune cells. 3. **Function:** TRBJ1 participates in the formation and function of TCR complexes, enabling T cells to recognize and respond to specific antigens. 4. **Variation:** The TRBJ1 gene exhibits polymorphism, resulting in the generation of multiple TCR sequences, which can influence the specificity and affinity of T cell responses. **Pathways and Functions:** The TRBJ1 gene is involved in the adaptive immune response through the following pathways and functions: 1. **T Cell Receptor Complex Formation:** TRBJ1 joins the TCR alpha chain to form a functional TCR heterodimer, enabling T cells to recognize and respond to specific antigens. 2. **Antigen Recognition:** The TRBJ1-TCR complex recognizes and binds to specific antigens, triggering T cell activation and proliferation. 3. **T Cell Activation:** The TRBJ1-TCR complex interacts with major histocompatibility complex (MHC) molecules, activating T cells and initiating an immune response. 4. **Immune Regulation:** TRBJ1 may also play a role in regulating T cell responses, including the modulation of T cell activation, proliferation, and apoptosis. **Clinical Significance:** The TRBJ1 gene has significant clinical implications in the following areas: 1. **Immunotherapy:** Understanding the function and specificity of TRBJ1-TCR complexes can inform the development of targeted immunotherapies, such as cancer vaccines and adoptive T cell therapies. 2. **Autoimmune Diseases:** Polymorphisms in the TRBJ1 gene may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes, by influencing T cell responses and immune regulation. 3. **Transplantation:** TRBJ1 may also play a role in graft rejection and immune tolerance in transplantation, highlighting the importance of understanding T cell responses and immune regulation in this context. In conclusion, the TRBJ1 gene is a crucial component of the adaptive immune response, participating in the formation and function of TCR complexes and influencing T cell recognition and response to specific antigens. Further research on TRBJ1 and its clinical significance is warranted to elucidate its role in immune regulation and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.