Details for: TRBJ1 3

Gene ID: 28633

Symbol: TRBJ1 3

Ensembl ID: ENSG00000282133

Description: T cell receptor beta joining 1-3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.93
    Marker Score: 3,141
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.66
    Marker Score: 862
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.05
    Marker Score: 172
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.04
    Marker Score: 76
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.03
    Marker Score: 1,745
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.01
    Marker Score: 41
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.01
    Marker Score: 12
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.01
    Marker Score: 5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.01
    Marker Score: 3
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.01
    Marker Score: 6
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0
    Marker Score: 6
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 23
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 3

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** TRBJ1 is a small peptide that joins the TCR alpha chain to form a functional TCR heterodimer. 2. **Expression:** TRBJ1 is significantly expressed in CD8-positive, alpha-beta T cells, natural killer cells, and B cells, among other immune cells. 3. **Function:** TRBJ1 participates in the formation and function of TCR complexes, enabling T cells to recognize and respond to specific antigens. 4. **Variation:** The TRBJ1 gene exhibits polymorphism, resulting in the generation of multiple TCR sequences, which can influence the specificity and affinity of T cell responses. **Pathways and Functions:** The TRBJ1 gene is involved in the adaptive immune response through the following pathways and functions: 1. **T Cell Receptor Complex Formation:** TRBJ1 joins the TCR alpha chain to form a functional TCR heterodimer, enabling T cells to recognize and respond to specific antigens. 2. **Antigen Recognition:** The TRBJ1-TCR complex recognizes and binds to specific antigens, triggering T cell activation and proliferation. 3. **T Cell Activation:** The TRBJ1-TCR complex interacts with major histocompatibility complex (MHC) molecules, activating T cells and initiating an immune response. 4. **Immune Regulation:** TRBJ1 may also play a role in regulating T cell responses, including the modulation of T cell activation, proliferation, and apoptosis. **Clinical Significance:** The TRBJ1 gene has significant clinical implications in the following areas: 1. **Immunotherapy:** Understanding the function and specificity of TRBJ1-TCR complexes can inform the development of targeted immunotherapies, such as cancer vaccines and adoptive T cell therapies. 2. **Autoimmune Diseases:** Polymorphisms in the TRBJ1 gene may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes, by influencing T cell responses and immune regulation. 3. **Transplantation:** TRBJ1 may also play a role in graft rejection and immune tolerance in transplantation, highlighting the importance of understanding T cell responses and immune regulation in this context. In conclusion, the TRBJ1 gene is a crucial component of the adaptive immune response, participating in the formation and function of TCR complexes and influencing T cell recognition and response to specific antigens. Further research on TRBJ1 and its clinical significance is warranted to elucidate its role in immune regulation and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.