Details for: TRAV11

Gene ID: 28675

Symbol: TRAV11

Ensembl ID: ENSG00000256474

Description: T cell receptor alpha variable 11 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.0455
    Cell Significance Index: 0.3700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0080
    Cell Significance Index: 0.1000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0036
    Cell Significance Index: 0.0400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0004
    Cell Significance Index: -0.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0015
    Cell Significance Index: -0.0100
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0027
    Cell Significance Index: -0.0200
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0049
    Cell Significance Index: -0.0500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0079
    Cell Significance Index: -0.1300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0092
    Cell Significance Index: -0.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0092
    Cell Significance Index: -0.1000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0107
    Cell Significance Index: -0.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0113
    Cell Significance Index: -0.1300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0114
    Cell Significance Index: -0.1400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0119
    Cell Significance Index: -0.1300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0127
    Cell Significance Index: -0.1500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0139
    Cell Significance Index: -0.2000
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.0140
    Cell Significance Index: -0.1600
  • Cell Name: kidney interstitial alternatively activated macrophage (CL1000695)
    Fold Change: -0.0143
    Cell Significance Index: -0.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0146
    Cell Significance Index: -0.2700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: -0.0147
    Cell Significance Index: -0.1500
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0152
    Cell Significance Index: -0.1400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0154
    Cell Significance Index: -0.1200
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0155
    Cell Significance Index: -0.1600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0172
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0178
    Cell Significance Index: -0.1800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0185
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0187
    Cell Significance Index: -0.1800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0189
    Cell Significance Index: -0.2300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0189
    Cell Significance Index: -0.2300
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0197
    Cell Significance Index: -0.2600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0208
    Cell Significance Index: -0.2500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0209
    Cell Significance Index: -0.2900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0211
    Cell Significance Index: -0.2500
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0219
    Cell Significance Index: -0.2400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0223
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0224
    Cell Significance Index: -0.2100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0228
    Cell Significance Index: -0.2300
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0232
    Cell Significance Index: -0.2800
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.0253
    Cell Significance Index: -0.2100
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0254
    Cell Significance Index: -0.2600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0274
    Cell Significance Index: -0.2600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0277
    Cell Significance Index: -0.2600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0277
    Cell Significance Index: -0.2800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0299
    Cell Significance Index: -0.2700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0301
    Cell Significance Index: -0.2600
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0303
    Cell Significance Index: -0.2600
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0309
    Cell Significance Index: -0.2700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0319
    Cell Significance Index: -0.2000
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: -0.0409
    Cell Significance Index: -0.2600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0448
    Cell Significance Index: -0.2400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.0886
    Cell Significance Index: -0.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAV11 is a member of the T cell receptor alpha variable (TRAV) family, which encodes the variable region of the alpha chain of the TCR. Unlike its counterparts, TRAV11 is a pseudogene, meaning it has undergone a non-functional mutation that prevents its expression as a functional TCR. Despite this, TRAV11 is significantly expressed in various T cell subsets, including naive thymus-derived CD4-positive T cells, regulatory T cells, and effector CD4-positive T cells. **Pathways and Functions:** TRAV11's expression in T cells suggests a role in T cell development and regulation. Studies have shown that TRAV11 is co-expressed with TRAV9, another TRAV family member, in thymocytes. This co-expression is thought to play a crucial role in the development and selection of T cells in the thymus. Moreover, TRAV11 has been implicated in the regulation of T cell responses, particularly in the context of regulatory T cells. These cells are essential for maintaining immune tolerance and preventing autoimmune disease. **Clinical Significance:** TRAV11's expression in T cells has significant implications for our understanding of immune-mediated diseases. For instance, the dysregulation of TRAV11 expression has been linked to autoimmune diseases such as multiple sclerosis and type 1 diabetes. Furthermore, TRAV11's role in regulatory T cell function highlights its potential as a therapeutic target for the treatment of autoimmune disorders. In addition, TRAV11's expression in mesothelial cells and stromal cells suggests a role in tissue homeostasis and immune tolerance. This has important implications for our understanding of cancer and autoimmune diseases, where immune tolerance and homeostasis are disrupted. **Conclusion:** In conclusion, TRAV11, a pseudogene in the TCR locus, plays a significant role in T cell development, regulation, and immune tolerance. Its expression in various T cell subsets and tissues highlights its importance in maintaining immune homeostasis and preventing autoimmune disease. Further research is needed to fully elucidate the functions of TRAV11 and its clinical significance, but its potential as a therapeutic target and diagnostic marker is an exciting area of exploration.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.