Details for: TRAJ27

Gene ID: 28728

Symbol: TRAJ27

Ensembl ID: ENSG00000211862

Description: T cell receptor alpha joining 27

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 5.3558
    Cell Significance Index: 104.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1972
    Cell Significance Index: 29.0000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.4017
    Cell Significance Index: 5.8500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3338
    Cell Significance Index: 4.3800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.2520
    Cell Significance Index: 3.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1868
    Cell Significance Index: 4.0900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.1043
    Cell Significance Index: 1.3400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1031
    Cell Significance Index: 1.6700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0142
    Cell Significance Index: 0.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0016
    Cell Significance Index: 0.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0034
    Cell Significance Index: -0.1500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0049
    Cell Significance Index: -0.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0063
    Cell Significance Index: -0.2400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0115
    Cell Significance Index: -0.1300
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0115
    Cell Significance Index: -0.1000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0119
    Cell Significance Index: -0.2300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0130
    Cell Significance Index: -0.1800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0140
    Cell Significance Index: -0.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0143
    Cell Significance Index: -0.1700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0178
    Cell Significance Index: -0.2100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0179
    Cell Significance Index: -0.2300
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0186
    Cell Significance Index: -0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0188
    Cell Significance Index: -0.3800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0215
    Cell Significance Index: -0.2500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0221
    Cell Significance Index: -0.2900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0229
    Cell Significance Index: -0.2100
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0231
    Cell Significance Index: -0.2000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0235
    Cell Significance Index: -0.2900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0266
    Cell Significance Index: -0.2500
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0305
    Cell Significance Index: -0.2900
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0311
    Cell Significance Index: -0.3400
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0322
    Cell Significance Index: -0.2800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0325
    Cell Significance Index: -0.3800
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0328
    Cell Significance Index: -0.3300
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0330
    Cell Significance Index: -0.3900
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0336
    Cell Significance Index: -0.2800
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0346
    Cell Significance Index: -0.2800
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: -0.0346
    Cell Significance Index: -0.3200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0369
    Cell Significance Index: -0.3500
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0371
    Cell Significance Index: -0.3500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0378
    Cell Significance Index: -0.4000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0386
    Cell Significance Index: -0.3900
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0403
    Cell Significance Index: -0.3600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0423
    Cell Significance Index: -0.5000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0453
    Cell Significance Index: -0.5700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0453
    Cell Significance Index: -0.5700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0493
    Cell Significance Index: -0.4700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0493
    Cell Significance Index: -0.5000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0501
    Cell Significance Index: -0.5600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0524
    Cell Significance Index: -0.6400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0532
    Cell Significance Index: -0.2900
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0545
    Cell Significance Index: -0.4700
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0547
    Cell Significance Index: -0.6400
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0655
    Cell Significance Index: -0.6600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0757
    Cell Significance Index: -0.6300
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0794
    Cell Significance Index: -0.6700
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0838
    Cell Significance Index: -0.6700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0901
    Cell Significance Index: -0.6700
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.2198
    Cell Significance Index: -0.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-type specificity:** TRAJ27 is expressed in a wide range of immune cells, including CD8-positive and CD4-positive T cells, B cells, innate lymphoid cells, and natural killer T cells. 2. **Developmental significance:** TRAJ27 is involved in the development of thymocytes, which are precursor cells that mature into alpha-beta T cells. 3. **Expression levels:** The expression levels of TRAJ27 vary across different cell types, with some cells expressing high levels of the gene, while others express low levels. 4. **Conservation:** TRAJ27 has been conserved across different species, suggesting its importance in the evolution of the immune system. **Pathways and Functions:** 1. **T cell receptor signaling:** TRAJ27 is involved in the signaling pathways of T cell receptors (TCRs), which are essential for the activation and function of T cells. 2. **Immunological tolerance:** TRAJ27 may play a role in the development of immunological tolerance, as it is expressed in cells that are involved in the regulation of the immune response. 3. **Cytokine production:** TRAJ27 may influence the production of cytokines, which are signaling molecules that are essential for the coordination of the immune response. 4. **Apoptosis:** TRAJ27 may also be involved in the regulation of apoptosis, or programmed cell death, which is essential for the elimination of self-reactive T cells. **Clinical Significance:** 1. **Autoimmune diseases:** Alterations in TRAJ27 expression have been associated with autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer:** TRAJ27 may also play a role in the development of cancer, as alterations in its expression have been observed in certain types of tumors. 3. **Immunodeficiency disorders:** TRAJ27 may be involved in the development of immunodeficiency disorders, such as severe combined immunodeficiency (SCID), which is characterized by impaired T cell function. 4. **Vaccine development:** TRAJ27 may be a target for vaccine development, as its expression is specific to certain cell types, which could be exploited to enhance the efficacy of vaccines. In conclusion, TRAJ27 is a gene that plays a critical role in the development and function of various immune cells. Its expression is essential for the proper functioning of these cells, influencing their development, maturation, and activation. Further research is needed to fully understand the mechanisms by which TRAJ27 regulates immune cell function and to explore its potential as a therapeutic target for autoimmune and cancer diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.