Details for: IGLV3 22

Gene ID: 28795

Symbol: IGLV3 22

Ensembl ID: ENSG00000211661

Description: immunoglobulin lambda variable 3-22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0116
    Cell Significance Index: -0.1600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0224
    Cell Significance Index: -0.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0357
    Cell Significance Index: -0.9100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0437
    Cell Significance Index: -0.8600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0513
    Cell Significance Index: -0.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0525
    Cell Significance Index: -0.9700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0529
    Cell Significance Index: -0.5400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0541
    Cell Significance Index: -0.3600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0596
    Cell Significance Index: -0.7400
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0626
    Cell Significance Index: -0.6400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0641
    Cell Significance Index: -0.6000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0646
    Cell Significance Index: -0.7200
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0648
    Cell Significance Index: -0.7200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0674
    Cell Significance Index: -0.8800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0675
    Cell Significance Index: -0.6600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0713
    Cell Significance Index: -0.8200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0719
    Cell Significance Index: -0.9300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0733
    Cell Significance Index: -0.7800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0759
    Cell Significance Index: -0.7100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0760
    Cell Significance Index: -0.8000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0771
    Cell Significance Index: -0.9100
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0774
    Cell Significance Index: -0.6900
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0777
    Cell Significance Index: -0.7400
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0781
    Cell Significance Index: -0.8800
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0782
    Cell Significance Index: -0.7200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0784
    Cell Significance Index: -0.8000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.0804
    Cell Significance Index: -0.6900
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0809
    Cell Significance Index: -0.6500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0815
    Cell Significance Index: -0.8600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0823
    Cell Significance Index: -0.7400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0834
    Cell Significance Index: -0.7800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0840
    Cell Significance Index: -0.7400
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0910
    Cell Significance Index: -0.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0916
    Cell Significance Index: -0.8800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0923
    Cell Significance Index: -0.8800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0924
    Cell Significance Index: -0.8600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0961
    Cell Significance Index: -1.2600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0962
    Cell Significance Index: -1.3200
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0977
    Cell Significance Index: -0.8700
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.0986
    Cell Significance Index: -0.8600
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1018
    Cell Significance Index: -0.7000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1035
    Cell Significance Index: -1.1300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1044
    Cell Significance Index: -1.3400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1045
    Cell Significance Index: -1.2400
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1048
    Cell Significance Index: -1.0900
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1061
    Cell Significance Index: -0.9000
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.1066
    Cell Significance Index: -0.8800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1090
    Cell Significance Index: -1.1000
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.1093
    Cell Significance Index: -1.1600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1119
    Cell Significance Index: -1.3800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1157
    Cell Significance Index: -0.7200
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1195
    Cell Significance Index: -0.9600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1200
    Cell Significance Index: -1.4600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1231
    Cell Significance Index: -1.4500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1315
    Cell Significance Index: -1.3900
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: -0.1459
    Cell Significance Index: -0.7300
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1507
    Cell Significance Index: -1.0600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1677
    Cell Significance Index: -1.8000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1710
    Cell Significance Index: -1.4400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1724
    Cell Significance Index: -2.0700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2074
    Cell Significance Index: -2.7600
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.2187
    Cell Significance Index: -1.3800
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.2432
    Cell Significance Index: -1.1200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.3787
    Cell Significance Index: -2.0300
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.7914
    Cell Significance Index: -3.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLV3-22 is a member of the immunoglobulin lambda (λ) gene family, which encodes for the light chains of antibodies. The λ light chains are distinct from the kappa (κ) and mu (μ) light chains, which are found in IgG and IgM antibodies, respectively. IGLV3-22 is characterized by its unique structure and sequence, which allows it to interact with the heavy chain of antibodies and contribute to the overall function of antibodies. **Pathways and Functions:** IGLV3-22 is involved in several key pathways and functions, including: 1. **Adaptive Immune Response:** IGLV3-22 is essential for the production of lambda light chains, which are critical for the formation of antibodies that recognize and neutralize pathogens. 2. **Immunoglobulin Complex Formation:** IGLV3-22 interacts with the heavy chain of antibodies to form immunoglobulin complexes, which are essential for the elimination of pathogens from the body. 3. **Plasma Membrane Expression:** IGLV3-22 is expressed on the plasma membrane of immune cells, including B cells and plasma cells, where it contributes to the regulation of immune responses. 4. **Cell Signaling:** IGLV3-22 may also participate in cell signaling pathways, influencing the activation and differentiation of immune cells. **Clinical Significance:** The dysregulation of IGLV3-22 has been implicated in various immune-related disorders, including: 1. **Immunodeficiency Disorders:** Mutations in IGLV3-22 can lead to impaired antibody production, increasing the risk of infections and autoimmune diseases. 2. **Cancer:** Abnormal expression of IGLV3-22 has been observed in certain types of cancer, suggesting its potential role in tumor development and progression. 3. **Autoimmune Diseases:** IGLV3-22 may contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, by promoting the production of autoantibodies. In conclusion, IGLV3-22 is a critical gene involved in the adaptive immune response, and its dysregulation can have significant clinical implications. Further research is needed to fully elucidate the role of IGLV3-22 in immune function and disease, and to explore its potential as a therapeutic target for the treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.