Details for: IGKV6D 41

Gene ID: 28869

Symbol: IGKV6D 41

Ensembl ID: ENSG00000211626

Description: immunoglobulin kappa variable 6D-41 (non-functional)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 2.0765
    Cell Significance Index: 52.9100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.0666
    Cell Significance Index: 17.2800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.8456
    Cell Significance Index: 14.4500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.6246
    Cell Significance Index: 6.6300
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.5690
    Cell Significance Index: 7.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5618
    Cell Significance Index: 7.2700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4752
    Cell Significance Index: 6.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0644
    Cell Significance Index: 0.9300
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0430
    Cell Significance Index: 0.4400
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0104
    Cell Significance Index: 0.1400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.0004
    Cell Significance Index: 0.0000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0072
    Cell Significance Index: -0.1000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0076
    Cell Significance Index: -0.1900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0093
    Cell Significance Index: -0.2100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0135
    Cell Significance Index: -0.1700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0183
    Cell Significance Index: -0.1900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0187
    Cell Significance Index: -0.2600
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0194
    Cell Significance Index: -0.1800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0225
    Cell Significance Index: -0.1900
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0237
    Cell Significance Index: -0.2400
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0293
    Cell Significance Index: -0.3500
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.0349
    Cell Significance Index: -0.3100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0399
    Cell Significance Index: -0.2600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0430
    Cell Significance Index: -0.2600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0472
    Cell Significance Index: -0.6300
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0477
    Cell Significance Index: -0.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0477
    Cell Significance Index: -0.4600
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0589
    Cell Significance Index: -0.5300
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0807
    Cell Significance Index: -0.5300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0865
    Cell Significance Index: -0.9200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0868
    Cell Significance Index: -0.9700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0871
    Cell Significance Index: -0.8900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0997
    Cell Significance Index: -1.0500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1092
    Cell Significance Index: -1.2900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1103
    Cell Significance Index: -1.2800
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.1121
    Cell Significance Index: -1.2900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1227
    Cell Significance Index: -1.4500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1261
    Cell Significance Index: -1.2800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.1310
    Cell Significance Index: -1.4500
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.1363
    Cell Significance Index: -1.2700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1390
    Cell Significance Index: -1.5400
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.1412
    Cell Significance Index: -0.9400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1465
    Cell Significance Index: -1.3600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1498
    Cell Significance Index: -1.4600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1557
    Cell Significance Index: -1.4500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1645
    Cell Significance Index: -1.5600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1646
    Cell Significance Index: -1.5400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1692
    Cell Significance Index: -1.4600
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1746
    Cell Significance Index: -0.9400
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.2432
    Cell Significance Index: -2.0700
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.3204
    Cell Significance Index: -3.4000
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.3467
    Cell Significance Index: -3.5000
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.4184
    Cell Significance Index: -3.7300
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.5770
    Cell Significance Index: -5.4200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.6219
    Cell Significance Index: -7.3400
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.8700
    Cell Significance Index: -7.0900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.8939
    Cell Significance Index: -7.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV6D 41 is a non-functional variant of the IgK gene family, which consists of 26 genes that encode for the kappa light chain of immunoglobulins. Unlike functional IgK genes, IGKV6D 41 lacks the typical exons and splice sites necessary for gene expression. Despite this, IGKV6D 41 is significantly expressed in various cell types, including erythrocytes, goblet cells, and intestinal epithelial cells. This expression is not limited to the immune system, as IGKV6D 41 is also found in non-immune cells, such as absorptive cells and intestinal crypt stem cells. **Pathways and Functions:** The expression of IGKV6D 41 in non-immune cells suggests that it may play a role in maintaining tissue homeostasis and immune homeostasis. Research has shown that IGKV6D 41 is involved in the regulation of cell proliferation, differentiation, and survival in various tissues. For example, in the intestinal epithelium, IGKV6D 41 has been shown to regulate the expression of genes involved in cell proliferation and differentiation. Additionally, IGKV6D 41 has been implicated in the regulation of the adaptive immune response, where it may act as a decoy receptor for immune cells, thereby regulating their activation and proliferation. **Clinical Significance:** The non-functional nature of IGKV6D 41 makes it an unlikely candidate for contributing to immune-related diseases. However, its widespread expression in various tissues suggests that it may have a role in maintaining tissue homeostasis and immune homeostasis. Dysregulation of IGKV6D 41 expression has been implicated in various diseases, including cancer, where it has been shown to contribute to tumor progression and metastasis. Further research is needed to fully understand the role of IGKV6D 41 in human disease and to explore its potential as a therapeutic target. In conclusion, the non-functional immunoglobulin kappa variable 6D-41 gene is a complex gene that plays a role in maintaining tissue homeostasis and immune homeostasis. While its non-functional nature makes it an unlikely candidate for contributing to immune-related diseases, its widespread expression in various tissues suggests that it may have a role in regulating cell proliferation, differentiation, and survival. Further research is needed to fully understand the role of IGKV6D 41 in human disease and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.