Details for: OR5AC2

Gene ID: 81050

Symbol: OR5AC2

Ensembl ID: ENSG00000196578

Description: olfactory receptor family 5 subfamily AC member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0965
    Cell Significance Index: 1.0500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0924
    Cell Significance Index: 1.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0706
    Cell Significance Index: 4.4500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0590
    Cell Significance Index: 0.7100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0379
    Cell Significance Index: 0.2900
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0015
    Cell Significance Index: -0.0100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0055
    Cell Significance Index: -1.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0057
    Cell Significance Index: -0.0800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0085
    Cell Significance Index: -0.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0109
    Cell Significance Index: -0.1300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0115
    Cell Significance Index: -0.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0140
    Cell Significance Index: -0.7800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0143
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0157
    Cell Significance Index: -0.1600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0204
    Cell Significance Index: -0.2100
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0211
    Cell Significance Index: -0.1300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0218
    Cell Significance Index: -0.1400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0244
    Cell Significance Index: -0.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0247
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0286
    Cell Significance Index: -0.5600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0352
    Cell Significance Index: -0.4100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0360
    Cell Significance Index: -0.4300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0371
    Cell Significance Index: -0.9400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0379
    Cell Significance Index: -0.3200
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.0419
    Cell Significance Index: -0.5200
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0442
    Cell Significance Index: -0.5500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0445
    Cell Significance Index: -0.5600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0467
    Cell Significance Index: -0.8000
  • Cell Name: diffuse bipolar 3b cell (CL4033030)
    Fold Change: -0.0473
    Cell Significance Index: -0.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0514
    Cell Significance Index: -0.8300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0524
    Cell Significance Index: -0.5800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0528
    Cell Significance Index: -0.6400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0541
    Cell Significance Index: -0.5700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0542
    Cell Significance Index: -0.6400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0552
    Cell Significance Index: -0.6000
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0574
    Cell Significance Index: -0.7100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0593
    Cell Significance Index: -0.3500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0605
    Cell Significance Index: -0.5400
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0607
    Cell Significance Index: -0.7600
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0619
    Cell Significance Index: -0.7400
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0629
    Cell Significance Index: -0.7800
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: -0.0690
    Cell Significance Index: -0.8300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0696
    Cell Significance Index: -0.9500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0697
    Cell Significance Index: -0.6900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0718
    Cell Significance Index: -0.6700
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0722
    Cell Significance Index: -0.7400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0741
    Cell Significance Index: -0.5700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0744
    Cell Significance Index: -0.7600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0782
    Cell Significance Index: -0.8100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0836
    Cell Significance Index: -0.8900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0863
    Cell Significance Index: -0.7600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0875
    Cell Significance Index: -0.7400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0876
    Cell Significance Index: -0.8300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0917
    Cell Significance Index: -0.5700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0942
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0948
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0950
    Cell Significance Index: -0.7500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0973
    Cell Significance Index: -1.0300
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.1036
    Cell Significance Index: -0.9100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1886
    Cell Significance Index: -1.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory Receptor Family:** OR5AC2 is part of the olfactory receptor family, which comprises genes that encode for receptors responsible for detecting odorant molecules in the air we breathe. These receptors are essential for our sense of smell and play a critical role in recognizing and distinguishing between different odors. 2. **G Protein-Coupled Receptor (GPCR):** OR5AC2 is a GPCR, a large family of receptors that respond to a variety of stimuli, including odorants, light, and hormones. GPCRs are the largest family of membrane receptors and are involved in numerous physiological processes, including sensory perception, immune response, and cardiovascular regulation. 3. **Wide Tissue Expression:** OR5AC2 is expressed in various cell types, including neuronal receptor cells, smooth muscle cells, endothelial cells, and megakaryocytes. This widespread expression suggests that OR5AC2 may play a role in multiple physiological processes beyond olfaction. **Pathways and Functions:** 1. **Detection of Chemical Stimuli:** OR5AC2 is involved in detecting chemical stimuli involved in sensory perception of smell. When an odorant molecule binds to the receptor, it triggers a signaling cascade that ultimately leads to the perception of a specific smell. 2. **Olfactory Signaling Pathway:** OR5AC2 is part of the olfactory signaling pathway, which is responsible for transmitting signals from the olfactory receptor to the brain. This pathway involves a series of molecular interactions, including the activation of G proteins and the production of second messengers. 3. **G Protein-Coupled Receptor Signaling Pathway:** OR5AC2 is also involved in the G protein-coupled receptor signaling pathway, which is a complex signaling cascade that involves multiple G proteins and downstream effectors. This pathway is involved in various physiological processes, including immune response, cardiovascular regulation, and cellular proliferation. **Clinical Significance:** 1. **Olfactory Disorders:** OR5AC2 has been implicated in various olfactory disorders, including anosmia (loss of smell) and hyposmia (reduced sense of smell). Mutations in the OR5AC2 gene may contribute to these disorders, highlighting the importance of this receptor in maintaining normal olfactory function. 2. **Cancer and Metastasis:** OR5AC2 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer. This overexpression may contribute to cancer progression and metastasis, suggesting that OR5AC2 may serve as a potential biomarker for cancer diagnosis and treatment. 3. **Neurological Disorders:** OR5AC2 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. The receptor's role in sensory perception and cognitive function may contribute to the development of these disorders, highlighting the importance of OR5AC2 in maintaining normal brain function. In conclusion, the OR5AC2 gene is a complex receptor that plays a crucial role in sensory perception of smell and multiple physiological processes beyond olfaction. Further research is needed to fully understand the mechanisms of OR5AC2 and its implications in human health and disease.

Genular Protein ID: 2510932136

Symbol: O5AC2_HUMAN

Name: Olfactory receptor 5AC2

UniProtKB Accession Codes:

Q9NZP5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 10706615

Title: The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates.

PubMed ID: 10706615

DOI: 10.1073/pnas.040580197

Sequence Information:

  • Length: 309
  • Mass: 35304
  • Checksum: BB9FD5CD01F0C5A9
  • Sequence:
    • MDISEGNKTL VTEFVLTGLT DRPWLHVLFF VVFLVVYLIT MVGNLGLIVL IWNDPHLHMP 
MYLFLGGLAF SDACTSTSIT PRMLVNFLDK TAMISLAECI TQFYFFASSA TTECFLLVMM 
AYDRYVAICN PLLYPVMMSN KLSAQLLSIS YVIGFLHPLV HVSLLLRLTF CRFNIIHYFY 
CEILQLFKIS CNGPSINALM IFIFGAFIQI PTLMTIIISY TRVLFDILKK KSEKGRSKAF 
STCGAHLLSV SLYYGTLIFM YVRPASGLAE DQDKVYSLFY TIIIPLLNPF IYSLRNKKVM 
HALRRVIRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.