Details for: IGHJ3

Gene ID: 28479

Symbol: IGHJ3

Ensembl ID: ENSG00000242887

Description: immunoglobulin heavy joining 3

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: 1.21
    Marker Score: 1,153
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.17
    Marker Score: 2,961
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,656
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 1
    Marker Score: 5,682
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,336
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1,565
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,732
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,251
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.75
    Marker Score: 512
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 549
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.45
    Marker Score: 507
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.32
    Marker Score: 89
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.28
    Marker Score: 121
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.26
    Marker Score: 808
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.18
    Marker Score: 64
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.11
    Marker Score: 64
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.11
    Marker Score: 82
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.11
    Marker Score: 81
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.09
    Marker Score: 76
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.09
    Marker Score: 75
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.09
    Marker Score: 116
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.08
    Marker Score: 70
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.07
    Marker Score: 76
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.07
    Marker Score: 111
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.07
    Marker Score: 74
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 96
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.06
    Marker Score: 77
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.06
    Marker Score: 74
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.03
    Marker Score: 76
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.03
    Marker Score: 73
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.02
    Marker Score: 68
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.01
    Marker Score: 73
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 82
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 45

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHJ3 is a gene located on chromosome 14, specifically on the long arm (q32.2). It is a member of the immunoglobulin heavy chain gene family and is involved in the joining of VH segments to the CH segments. The gene is characterized by its high expression levels in B cells, which are the primary producers of immunoglobulins. Additionally, IGHJ3 is also expressed in various non-immune cells, including intestinal epithelial cells, stem cells, and dendritic cells. This gene's expression in these cell types is thought to be involved in cell differentiation, proliferation, and survival. **Pathways and Functions:** The IGHJ3 gene is involved in several key pathways, including: 1. **Immunoglobulin Class Switching:** IGHJ3 plays a crucial role in the joining of VH segments to the CH segments, facilitating the assembly of mature immunoglobulins. This process is essential for class switching, which allows B cells to produce different types of immunoglobulins in response to changing antigenic environments. 2. **Cell Signaling:** IGHJ3 is involved in cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. These pathways regulate cell proliferation, differentiation, and survival, and are critical for the development and function of B cells. 3. **Intestinal Homeostasis:** IGHJ3 is expressed in intestinal epithelial cells, where it is thought to play a role in maintaining intestinal homeostasis. This includes regulating the proliferation and differentiation of intestinal epithelial cells, as well as maintaining the integrity of the epithelial barrier. **Clinical Significance:** The IGHJ3 gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Abnormal expression of IGHJ3 has been observed in various autoimmune diseases, including rheumatoid arthritis and lupus. Additionally, IGHJ3 has been found to be overexpressed in certain types of cancer, including lymphoma and leukemia. Furthermore, IGHJ3 has been implicated in the development of immune-related disorders, such as graft-versus-host disease and multiple sclerosis. In conclusion, the IGHJ3 gene is a vital component of the immune system, playing a critical role in immunoglobulin production and class switching. Its expression in non-immune cells suggests a broader functional scope, warranting further investigation into its mechanisms and significance. Further research into the IGHJ3 gene and its role in disease will provide valuable insights into the development of novel therapeutic strategies for autoimmune diseases and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.