Details for: IGHJ3

Gene ID: 28479

Symbol: IGHJ3

Ensembl ID: ENSG00000242887

Description: immunoglobulin heavy joining 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.2060
    Cell Significance Index: 53.4400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6309
    Cell Significance Index: 9.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0086
    Cell Significance Index: -0.4000
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0124
    Cell Significance Index: -0.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0143
    Cell Significance Index: -0.2800
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0145
    Cell Significance Index: -0.1200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0245
    Cell Significance Index: -0.3200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0251
    Cell Significance Index: -0.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0269
    Cell Significance Index: -0.6900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0363
    Cell Significance Index: -0.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0363
    Cell Significance Index: -0.6700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0421
    Cell Significance Index: -0.5600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0426
    Cell Significance Index: -0.6900
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0483
    Cell Significance Index: -0.4900
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0488
    Cell Significance Index: -0.5500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0516
    Cell Significance Index: -0.6100
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0526
    Cell Significance Index: -0.6900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0545
    Cell Significance Index: -0.6400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0556
    Cell Significance Index: -0.5900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0567
    Cell Significance Index: -0.6600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0570
    Cell Significance Index: -0.6100
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0587
    Cell Significance Index: -0.6800
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0601
    Cell Significance Index: -0.7100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0605
    Cell Significance Index: -0.6700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0623
    Cell Significance Index: -0.5700
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0630
    Cell Significance Index: -0.6700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0631
    Cell Significance Index: -0.6400
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0632
    Cell Significance Index: -0.6700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0634
    Cell Significance Index: -0.6500
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0638
    Cell Significance Index: -0.4300
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0647
    Cell Significance Index: -0.6000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0647
    Cell Significance Index: -0.7800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0648
    Cell Significance Index: -0.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0666
    Cell Significance Index: -0.6400
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0671
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0674
    Cell Significance Index: -0.7100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0676
    Cell Significance Index: -0.5800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0687
    Cell Significance Index: -0.6500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0691
    Cell Significance Index: -0.6600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0692
    Cell Significance Index: -0.6600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0720
    Cell Significance Index: -0.6700
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0740
    Cell Significance Index: -0.6600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0756
    Cell Significance Index: -0.9600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.0775
    Cell Significance Index: -0.6900
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0779
    Cell Significance Index: -0.6400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0788
    Cell Significance Index: -0.6800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0795
    Cell Significance Index: -0.7100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0800
    Cell Significance Index: -0.6800
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.0886
    Cell Significance Index: -0.6800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0890
    Cell Significance Index: -0.8200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0891
    Cell Significance Index: -0.9600
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0891
    Cell Significance Index: -0.9700
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0914
    Cell Significance Index: -0.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0915
    Cell Significance Index: -1.1800
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0976
    Cell Significance Index: -0.6400
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.1011
    Cell Significance Index: -1.0000
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1037
    Cell Significance Index: -0.5600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1155
    Cell Significance Index: -0.6300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1475
    Cell Significance Index: -1.0600
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1576
    Cell Significance Index: -1.6400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1664
    Cell Significance Index: -1.7800
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2859
    Cell Significance Index: -1.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHJ3 is a gene located on chromosome 14, specifically on the long arm (q32.2). It is a member of the immunoglobulin heavy chain gene family and is involved in the joining of VH segments to the CH segments. The gene is characterized by its high expression levels in B cells, which are the primary producers of immunoglobulins. Additionally, IGHJ3 is also expressed in various non-immune cells, including intestinal epithelial cells, stem cells, and dendritic cells. This gene's expression in these cell types is thought to be involved in cell differentiation, proliferation, and survival. **Pathways and Functions:** The IGHJ3 gene is involved in several key pathways, including: 1. **Immunoglobulin Class Switching:** IGHJ3 plays a crucial role in the joining of VH segments to the CH segments, facilitating the assembly of mature immunoglobulins. This process is essential for class switching, which allows B cells to produce different types of immunoglobulins in response to changing antigenic environments. 2. **Cell Signaling:** IGHJ3 is involved in cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. These pathways regulate cell proliferation, differentiation, and survival, and are critical for the development and function of B cells. 3. **Intestinal Homeostasis:** IGHJ3 is expressed in intestinal epithelial cells, where it is thought to play a role in maintaining intestinal homeostasis. This includes regulating the proliferation and differentiation of intestinal epithelial cells, as well as maintaining the integrity of the epithelial barrier. **Clinical Significance:** The IGHJ3 gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Abnormal expression of IGHJ3 has been observed in various autoimmune diseases, including rheumatoid arthritis and lupus. Additionally, IGHJ3 has been found to be overexpressed in certain types of cancer, including lymphoma and leukemia. Furthermore, IGHJ3 has been implicated in the development of immune-related disorders, such as graft-versus-host disease and multiple sclerosis. In conclusion, the IGHJ3 gene is a vital component of the immune system, playing a critical role in immunoglobulin production and class switching. Its expression in non-immune cells suggests a broader functional scope, warranting further investigation into its mechanisms and significance. Further research into the IGHJ3 gene and its role in disease will provide valuable insights into the development of novel therapeutic strategies for autoimmune diseases and cancer.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.