Details for: TRAJ9

Gene ID: 28746

Symbol: TRAJ9

Ensembl ID: ENSG00000211880

Description: T cell receptor alpha joining 9

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1024
    Cell Significance Index: 26.7000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3744
    Cell Significance Index: 5.4600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1849
    Cell Significance Index: 3.0000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.0046
    Cell Significance Index: 0.0600
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: 0.0035
    Cell Significance Index: 0.0300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0003
    Cell Significance Index: 0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0008
    Cell Significance Index: -0.1600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0048
    Cell Significance Index: -0.1800
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0069
    Cell Significance Index: -0.0900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0076
    Cell Significance Index: -0.0900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0079
    Cell Significance Index: -0.0700
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0085
    Cell Significance Index: -0.0800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0086
    Cell Significance Index: -0.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0089
    Cell Significance Index: -0.1000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0090
    Cell Significance Index: -0.1800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0095
    Cell Significance Index: -0.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0110
    Cell Significance Index: -0.1400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0113
    Cell Significance Index: -0.0900
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0119
    Cell Significance Index: -0.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0159
    Cell Significance Index: -0.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0179
    Cell Significance Index: -0.3300
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0189
    Cell Significance Index: -0.2000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0197
    Cell Significance Index: -0.2100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.0207
    Cell Significance Index: -0.1800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0214
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0235
    Cell Significance Index: -0.2200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0235
    Cell Significance Index: -0.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0246
    Cell Significance Index: -0.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0254
    Cell Significance Index: -0.3000
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0271
    Cell Significance Index: -0.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0287
    Cell Significance Index: -0.3300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0330
    Cell Significance Index: -0.3400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0330
    Cell Significance Index: -0.1800
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0377
    Cell Significance Index: -0.3300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0387
    Cell Significance Index: -0.3900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0396
    Cell Significance Index: -0.4000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0429
    Cell Significance Index: -0.3700
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: -0.0454
    Cell Significance Index: -0.4600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0474
    Cell Significance Index: -0.5500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0487
    Cell Significance Index: -0.5600
  • Cell Name: platelet (CL0000233)
    Fold Change: -0.0505
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0520
    Cell Significance Index: -0.5000
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0538
    Cell Significance Index: -0.4000
  • Cell Name: naive T cell (CL0000898)
    Fold Change: -0.0583
    Cell Significance Index: -0.5300
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0601
    Cell Significance Index: -0.5600
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0640
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0692
    Cell Significance Index: -0.5600
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1805
    Cell Significance Index: -0.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ9 is a member of the T cell receptor (TCR) family, which is essential for recognizing and responding to antigens. The TRAJ9 gene is located on chromosome 1q21.1 and consists of 11 exons that encode a protein with 345 amino acids. The TRAJ9 protein shares structural homology with other TCR-associated proteins, such as TCR alpha chains, and is thought to play a role in the assembly and stabilization of the TCR complex. The expression of TRAJ9 is characterized by its widespread presence in various immune cells, including CD8+ and CD4+ T cells, B cells, and innate lymphoid cells. **Pathways and Functions:** The TRAJ9 protein is involved in several key signaling pathways that regulate immune cell development, activation, and function. These pathways include: 1. **TCR signaling pathway**: TRAJ9 is thought to play a role in the assembly and stabilization of the TCR complex, which is essential for recognizing and responding to antigens. 2. **Notch signaling pathway**: TRAJ9 has been shown to interact with the Notch signaling pathway, which is crucial for the development and differentiation of T cells. 3. **JAK/STAT signaling pathway**: TRAJ9 may also be involved in the JAK/STAT signaling pathway, which is essential for the regulation of immune cell proliferation and survival. 4. **Cytokine signaling pathway**: TRAJ9 may play a role in the regulation of cytokine signaling, which is critical for the coordination of immune responses. **Clinical Significance:** The TRAJ9 gene has been implicated in several immune-related disorders, including: 1. **Autoimmune diseases**: Dysregulation of TRAJ9 expression has been linked to autoimmune diseases such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer**: TRAJ9 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma. 3. **Infectious diseases**: TRAJ9 may play a role in the regulation of immune responses to infectious diseases, such as tuberculosis and HIV. 4. **Immunodeficiency disorders**: TRAJ9 has been implicated in immunodeficiency disorders, such as severe combined immunodeficiency (SCID), which is characterized by impaired T cell development and function. In conclusion, the TRAJ9 gene is a critical component of the immune system, and its dysregulation has been linked to various immune-related disorders. Further research is needed to fully elucidate the mechanisms by which TRAJ9 regulates immune cell development, activation, and function, and to explore its potential as a therapeutic target for the treatment of immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.