Details for: KRT33A

Gene ID: 3883

Symbol: KRT33A

Ensembl ID: ENSG00000006059

Description: keratin 33A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.35
    Marker Score: 103061
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.92
    Marker Score: 161388
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.48
    Marker Score: 8008
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.71
    Marker Score: 30354
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.61
    Marker Score: 6574
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.14
    Marker Score: 3161
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.82
    Marker Score: 4480
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 2.74
    Marker Score: 711
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.28
    Marker Score: 713
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 2.2
    Marker Score: 710
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 2.19
    Marker Score: 694
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.96
    Marker Score: 711
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.92
    Marker Score: 711
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.36
    Marker Score: 714
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7688
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.07
    Marker Score: 714
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.04
    Marker Score: 708
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1
    Marker Score: 688
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71136
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.98
    Marker Score: 47361
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30344
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.96
    Marker Score: 1560
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5301
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.86
    Marker Score: 662
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.81
    Marker Score: 741
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.79
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.79
    Marker Score: 407
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 709
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.72
    Marker Score: 428
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.69
    Marker Score: 554
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.68
    Marker Score: 713
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.66
    Marker Score: 673
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.65
    Marker Score: 713
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.64
    Marker Score: 712
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.59
    Marker Score: 694
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.55
    Marker Score: 713
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.49
    Marker Score: 687
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.49
    Marker Score: 697
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.46
    Marker Score: 489
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.41
    Marker Score: 703
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.39
    Marker Score: 721
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.37
    Marker Score: 607
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.29
    Marker Score: 694
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.28
    Marker Score: 580
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.25
    Marker Score: 700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.22
    Marker Score: 594
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.22
    Marker Score: 742
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.2
    Marker Score: 702.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.18
    Marker Score: 713
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.11
    Marker Score: 604
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.09
    Marker Score: 703
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.09
    Marker Score: 669
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.08
    Marker Score: 701
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 714

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** - KRT33A is a transmembrane protein with a molecular weight of approximately 400 amino acids. - It is expressed in a variety of cell types, including epithelial cells, endothelial cells, and immune cells. - It is a key component of the cornified envelope, which is a protective layer that surrounds cells in stratified squamous epithelia. - It is also involved in the organization of the intermediate filament, a cytoskeletal protein that helps to maintain the integrity of the cell membrane. **Pathways and functions** - KRT33A is involved in the formation of the cornified envelope by interacting with other keratin proteins. - It is also involved in the organization of the intermediate filament by interacting with other cytoskeletal proteins. - It is involved in the regulation of epithelial cell differentiation by promoting the expression of epithelial genes. - It is also involved in the regulation of immune cell differentiation by promoting the expression of immune genes. **Clinical significance** - Mutations in KRT33A have been linked to a number of human diseases, including psoriasis, scleroderma, and cancer. - These diseases are characterized by abnormal skin growth and inflammation. - Targeting KRT33A has been investigated as a therapeutic strategy for these diseases.

Genular Protein ID: 1778890637

Symbol: KT33A_HUMAN

Name: Keratin, type I cuticular Ha3-I

UniProtKB Accession Codes:

O76009 B2RA87 Q6NTB9 Q6ZZB9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 EMBL 6 Ensembl 3 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9756910

Title: Characterization of a 190-kilobase pair domain of human type I hair keratin genes.

PubMed ID: 9756910

DOI: 10.1074/jbc.273.41.26683

PubMed ID: 15617563

Title: The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.

PubMed ID: 15617563

DOI: 10.1111/j.1432-0436.2004.07209006.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 404
  • Mass: 45940
  • Checksum: 14B0C556E64485B0
  • Sequence:
    • MSYSCGLPSL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM 
QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLVC ASYQSYFKTI EELQQKILCS 
KSENARLVVQ IDNAKLASDD FRTKYETELS LRQLVESDIN GLRRILDELT LCRSDLEAQV 
ESLKEELLCL KQNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNQVLNETRS QYEALVETNR 
REVEQWFATQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL 
TESEARYSSQ LSQVQRLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL 
ESEDCKLPSN PCATTNACDK STGPCISNPC GLRARCGPCN TFGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.