Details for: MAGEA9

Gene ID: 4108

Symbol: MAGEA9

Ensembl ID: ENSG00000123584

Description: MAGE family member A9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.6523
    Cell Significance Index: 11.1500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5309
    Cell Significance Index: 6.8700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5192
    Cell Significance Index: 7.1200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.3210
    Cell Significance Index: 3.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0193
    Cell Significance Index: 0.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0062
    Cell Significance Index: 0.0600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0026
    Cell Significance Index: 0.0300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0026
    Cell Significance Index: -0.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0041
    Cell Significance Index: -0.5700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0071
    Cell Significance Index: -0.1800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0091
    Cell Significance Index: -0.1200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0120
    Cell Significance Index: -0.1700
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0158
    Cell Significance Index: -0.1900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0180
    Cell Significance Index: -0.4800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0181
    Cell Significance Index: -0.1700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0189
    Cell Significance Index: -0.3000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0191
    Cell Significance Index: -0.2500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0202
    Cell Significance Index: -0.2600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0244
    Cell Significance Index: -0.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0256
    Cell Significance Index: -0.5100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0260
    Cell Significance Index: -0.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0261
    Cell Significance Index: -0.5500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0269
    Cell Significance Index: -0.3200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0271
    Cell Significance Index: -0.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0271
    Cell Significance Index: -0.5700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0276
    Cell Significance Index: -0.3600
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0277
    Cell Significance Index: -0.3400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0277
    Cell Significance Index: -0.4200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0284
    Cell Significance Index: -0.2900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0295
    Cell Significance Index: -0.3400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0298
    Cell Significance Index: -0.3600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0313
    Cell Significance Index: -0.4300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0322
    Cell Significance Index: -0.6400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0323
    Cell Significance Index: -0.3500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0333
    Cell Significance Index: -0.5400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0334
    Cell Significance Index: -0.4700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0345
    Cell Significance Index: -0.4000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0347
    Cell Significance Index: -0.3600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0348
    Cell Significance Index: -0.3700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0403
    Cell Significance Index: -0.4500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0406
    Cell Significance Index: -0.4800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0425
    Cell Significance Index: -0.3600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0436
    Cell Significance Index: -0.4600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0442
    Cell Significance Index: -0.4800
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0460
    Cell Significance Index: -0.3800
  • Cell Name: H2 horizontal cell (CL0004218)
    Fold Change: -0.0491
    Cell Significance Index: -0.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0499
    Cell Significance Index: -0.7100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0500
    Cell Significance Index: -0.5100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0545
    Cell Significance Index: -0.7100
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.0563
    Cell Significance Index: -0.5400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0599
    Cell Significance Index: -0.5500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0625
    Cell Significance Index: -0.7100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0658
    Cell Significance Index: -0.5800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0755
    Cell Significance Index: -0.5700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0784
    Cell Significance Index: -0.4200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.0875
    Cell Significance Index: -0.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding gene**: MAGEA9 lacks a coding sequence, suggesting its primary function lies in regulating gene expression rather than encoding a protein product. 2. **Histone deacetylase binding**: MAGEA9 interacts with histone deacetylases, enzymes responsible for removing acetyl groups from histones, thereby influencing chromatin structure and gene expression. 3. **Negative regulation of transcription by RNA polymerase II**: MAGEA9 can inhibit the activity of RNA polymerase II, a crucial enzyme in transcriptional initiation, thereby suppressing the expression of target genes. 4. **Cell-type specific expression**: MAGEA9 is expressed in various cell types, including immune cells, progenitor cells, and cells of the nervous system, highlighting its role in tissue-specific regulation. **Pathways and Functions:** MAGEA9's involvement in the regulation of transcriptional control and histone deacetylation has far-reaching implications for various cellular processes: 1. **Immunological regulation**: By modulating the expression of immune-related genes, MAGEA9 contributes to the maintenance of immune homeostasis and the suppression of aberrant immune responses. 2. **Tumor microenvironment**: MAGEA9's expression in cancer cells can influence the tumor microenvironment, promoting immune evasion and tumor growth. 3. **Neurological development**: MAGEA9's role in regulating gene expression in progenitor cells and oligodendrocytes highlights its importance in neurological development and tissue homeostasis. 4. **Cell differentiation**: MAGEA9's interaction with histone deacetylases and RNA polymerase II suggests its involvement in cell differentiation processes, including the regulation of gene expression in response to environmental cues. **Clinical Significance:** The study of MAGEA9's role in the tumor microenvironment and its potential as a therapeutic target has significant implications for cancer immunotherapy: 1. **Immunotherapy**: MAGEA9's involvement in immune evasion mechanisms makes it a potential target for cancer immunotherapy strategies aimed at restoring immune function and promoting anti-tumor responses. 2. **Cancer diagnosis**: The expression of MAGEA9 in various cell types may serve as a biomarker for cancer diagnosis and monitoring, particularly in cases where traditional biomarkers are not available. 3. **Neurological disorders**: MAGEA9's role in neurological development and tissue homeostasis highlights its potential as a therapeutic target for neurological disorders, such as multiple sclerosis and neurodegenerative diseases. In conclusion, the MAGEA9 gene represents a complex and multifaceted player in the regulation of gene expression and immune function, with significant implications for our understanding of tumor immunology and neurological development. Further research is needed to fully elucidate the functional roles of MAGEA9 and its potential applications in cancer therapy and neurological disorders.

Genular Protein ID: 2185066440

Symbol: MAGA9_HUMAN

Name: Melanoma-associated antigen 9

UniProtKB Accession Codes:

P43362 A8K8A7 Q7Z5K4 Q92910

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CTD 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 2 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 2 GeneCards 2 GeneTree 1 GeneWiki 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 5 KEGG 2 MANE-Select 2 MIM 2 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 6 SMART 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7927540

Title: Structure, chromosomal localization, and expression of 12 genes of the MAGE family.

PubMed ID: 7927540

DOI: 10.1007/bf01246677

PubMed ID: 9147653

Title: Molecular and phenotypic variation in patients with severe Hunter syndrome.

PubMed ID: 9147653

DOI: 10.1093/hmg/6.3.479

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20598277

Title: Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.

PubMed ID: 20598277

DOI: 10.1016/j.ajhg.2010.06.008

Sequence Information:

  • Length: 315
  • Mass: 35088
  • Checksum: 7FD2ED10D680D928
  • Sequence:
    • MSLEQRSPHC KPDEDLEAQG EDLGLMGAQE PTGEEEETTS SSDSKEEEVS AAGSSSPPQS 
PQGGASSSIS VYYTLWSQFD EGSSSQEEEE PSSSVDPAQL EFMFQEALKL KVAELVHFLL 
HKYRVKEPVT KAEMLESVIK NYKRYFPVIF GKASEFMQVI FGTDVKEVDP AGHSYILVTA 
LGLSCDSMLG DGHSMPKAAL LIIVLGVILT KDNCAPEEVI WEALSVMGVY VGKEHMFYGE 
PRKLLTQDWV QENYLEYRQV PGSDPAHYEF LWGSKAHAET SYEKVINYLV MLNAREPICY 
PSLYEEVLGE EQEGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.