Details for: TEAD4

Gene ID: 7004

Symbol: TEAD4

Ensembl ID: ENSG00000197905

Description: TEA domain transcription factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.7552
    Cell Significance Index: -12.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.2173
    Cell Significance Index: -12.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 29.0814
    Cell Significance Index: -11.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9274
    Cell Significance Index: -12.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1120
    Cell Significance Index: -12.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.4941
    Cell Significance Index: 64.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.8324
    Cell Significance Index: 44.7100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.7055
    Cell Significance Index: 24.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3522
    Cell Significance Index: 257.3300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.0517
    Cell Significance Index: 16.9700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8452
    Cell Significance Index: 13.5600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.8354
    Cell Significance Index: 6.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7789
    Cell Significance Index: 154.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7774
    Cell Significance Index: 76.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7349
    Cell Significance Index: 44.1200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7311
    Cell Significance Index: 19.9000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.6820
    Cell Significance Index: 7.8600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6522
    Cell Significance Index: 7.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5885
    Cell Significance Index: 531.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5656
    Cell Significance Index: 61.5200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.5086
    Cell Significance Index: 3.8400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4827
    Cell Significance Index: 8.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4544
    Cell Significance Index: 66.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4287
    Cell Significance Index: 11.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4254
    Cell Significance Index: 49.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4120
    Cell Significance Index: 67.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2824
    Cell Significance Index: 19.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2710
    Cell Significance Index: 20.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2590
    Cell Significance Index: 44.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2218
    Cell Significance Index: 1.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2076
    Cell Significance Index: 5.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1640
    Cell Significance Index: 4.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1577
    Cell Significance Index: 12.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1315
    Cell Significance Index: 5.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1286
    Cell Significance Index: 16.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1217
    Cell Significance Index: 1.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0964
    Cell Significance Index: 3.3500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0877
    Cell Significance Index: 0.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0863
    Cell Significance Index: 1.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0850
    Cell Significance Index: 46.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0573
    Cell Significance Index: 11.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0521
    Cell Significance Index: 1.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0356
    Cell Significance Index: 54.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0337
    Cell Significance Index: 62.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0317
    Cell Significance Index: 0.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0248
    Cell Significance Index: 0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0246
    Cell Significance Index: 7.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0222
    Cell Significance Index: 9.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0141
    Cell Significance Index: 1.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0008
    Cell Significance Index: -0.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0029
    Cell Significance Index: -1.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0067
    Cell Significance Index: -9.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0097
    Cell Significance Index: -1.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0139
    Cell Significance Index: -10.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0154
    Cell Significance Index: -11.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0174
    Cell Significance Index: -7.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0174
    Cell Significance Index: -6.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0194
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0201
    Cell Significance Index: -12.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0210
    Cell Significance Index: -11.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0226
    Cell Significance Index: -2.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0303
    Cell Significance Index: -5.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0417
    Cell Significance Index: -5.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0466
    Cell Significance Index: -4.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0549
    Cell Significance Index: -0.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0550
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0601
    Cell Significance Index: -12.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0656
    Cell Significance Index: -3.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0710
    Cell Significance Index: -4.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0806
    Cell Significance Index: -3.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0875
    Cell Significance Index: -10.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0943
    Cell Significance Index: -1.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1102
    Cell Significance Index: -3.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1113
    Cell Significance Index: -2.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1123
    Cell Significance Index: -11.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1191
    Cell Significance Index: -8.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1405
    Cell Significance Index: -11.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1476
    Cell Significance Index: -1.2400
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1640
    Cell Significance Index: -2.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1654
    Cell Significance Index: -8.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1726
    Cell Significance Index: -10.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1789
    Cell Significance Index: -11.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1800
    Cell Significance Index: -9.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1812
    Cell Significance Index: -11.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1979
    Cell Significance Index: -10.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2070
    Cell Significance Index: -3.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2220
    Cell Significance Index: -3.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2383
    Cell Significance Index: -6.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2414
    Cell Significance Index: -8.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2457
    Cell Significance Index: -10.8700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2568
    Cell Significance Index: -2.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2774
    Cell Significance Index: -8.1700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2859
    Cell Significance Index: -1.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2884
    Cell Significance Index: -10.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3027
    Cell Significance Index: -9.9100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3031
    Cell Significance Index: -12.4200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3067
    Cell Significance Index: -6.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3116
    Cell Significance Index: -11.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding transcription activator activity**: TEAD4 exhibits a high degree of sequence specificity, allowing it to interact with RNA polymerase II and regulate gene expression. 2. **TEA domain structure**: The TEA domain is a conserved motif that mediates the interaction between TEAD4 and DNA, enabling it to bind to specific transcriptional enhancer elements. 3. **Widespread expression**: TEAD4 is expressed in various cell types, including pancreatic acinar cells, T-helper 17 cells, and placental villous trophoblasts, indicating its diverse roles in development and disease. 4. **Regulation of stem cell population maintenance**: TEAD4 is involved in the regulation of stem cell populations, suggesting its role in tissue homeostasis and regeneration. **Pathways and Functions:** 1. **Cell fate specification**: TEAD4 plays a crucial role in determining the fate of cells during development, including the specification of embryonic organ development and the formation of axial mesoderm. 2. **Chromatin remodeling**: TEAD4 interacts with chromatin remodeling complexes to facilitate the regulation of gene expression. 3. **Hippo signaling pathway**: TEAD4 is involved in the regulation of the Hippo signaling pathway, which plays a critical role in organ size control and tissue homeostasis. 4. **Transcriptional regulation**: TEAD4 regulates gene expression through the recruitment of RNA polymerase II, influencing various cellular processes, including cell proliferation, differentiation, and survival. **Clinical Significance:** TEAD4's involvement in developmental biology and disease highlights its potential as a therapeutic target for various conditions, including: 1. **Cancer**: TEAD4's role in regulating cell proliferation and differentiation makes it a potential target for cancer therapy. 2. **Developmental disorders**: TEAD4's involvement in embryonic development and tissue formation suggests its potential as a therapeutic target for developmental disorders, such as congenital anomalies. 3. **Stem cell diseases**: TEAD4's role in regulating stem cell populations makes it a potential target for therapies aimed at promoting tissue regeneration and repair. In conclusion, TEAD4 is a multifunctional transcription factor that plays a critical role in various cellular processes, including cell fate specification, development, and disease. Further research is needed to fully elucidate the mechanisms by which TEAD4 regulates gene expression and to explore its potential as a therapeutic target for various conditions.

Genular Protein ID: 4192654971

Symbol: TEAD4_HUMAN

Name: Transcriptional enhancer factor TEF-3

UniProtKB Accession Codes:

Q15561 H0Y308 Q6MZR9 Q8NEV5 Q92883 Q96BK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIRSF 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8921372

Title: Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family.

PubMed ID: 8921372

DOI: 10.1006/geno.1996.0522

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8702974

Title: A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain.

PubMed ID: 8702974

DOI: 10.1074/jbc.271.36.21775

PubMed ID: 18579750

Title: TEAD mediates YAP-dependent gene induction and growth control.

PubMed ID: 18579750

DOI: 10.1101/gad.1664408

PubMed ID: 19324877

Title: TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.

PubMed ID: 19324877

DOI: 10.1074/jbc.m900843200

PubMed ID: 20123908

Title: Structural basis of YAP recognition by TEAD4 in the hippo pathway.

PubMed ID: 20123908

DOI: 10.1101/gad.1865310

Sequence Information:

  • Length: 434
  • Mass: 48329
  • Checksum: 544DDFD86E88D9A8
  • Sequence:
    • MEGTAGTITS NEWSSPTSPE GSTASGGSQA LDKPIDNDAE GVWSPDIEQS FQEALAIYPP 
CGRRKIILSD EGKMYGRNEL IARYIKLRTG KTRTRKQVSS HIQVLARRKA REIQAKLKDQ 
AAKDKALQSM AAMSSAQIIS ATAFHSSMAL ARGPGRPAVS GFWQGALPGQ AGTSHDVKPF 
SQQTYAVQPP LPLPGFESPA GPAPSPSAPP APPWQGRSVA SSKLWMLEFS AFLEQQQDPD 
TYNKHLFVHI GQSSPSYSDP YLEAVDIRQI YDKFPEKKGG LKDLFERGPS NAFFLVKFWA 
DLNTNIEDEG SSFYGVSSQY ESPENMIITC STKVCSFGKQ VVEKVETEYA RYENGHYSYR 
IHRSPLCEYM INFIHKLKHL PEKYMMNSVL ENFTILQVVT NRDTQETLLC IAYVFEVSAS 
EHGAQHHIYR LVKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.