Details for: SNORD42A

Gene ID: 26809

Symbol: SNORD42A

Ensembl ID: ENSG00000238649

Description: small nucleolar RNA, C/D box 42A

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.1936
    Cell Significance Index: 11.7800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.4013
    Cell Significance Index: 5.0700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.2400
    Cell Significance Index: 3.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2116
    Cell Significance Index: 2.1900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0981
    Cell Significance Index: 1.2600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.0920
    Cell Significance Index: 0.9400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0838
    Cell Significance Index: 1.4100
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.0724
    Cell Significance Index: 0.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0542
    Cell Significance Index: 0.8000
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.0519
    Cell Significance Index: 0.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0171
    Cell Significance Index: 0.2000
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.0155
    Cell Significance Index: 0.1700
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0116
    Cell Significance Index: 0.1400
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.0083
    Cell Significance Index: 0.0900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0060
    Cell Significance Index: 0.0700
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.0054
    Cell Significance Index: 0.0600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0012
    Cell Significance Index: -0.3500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0089
    Cell Significance Index: -0.1200
  • Cell Name: respiratory hillock cell (CL4030023)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0106
    Cell Significance Index: -0.1300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0129
    Cell Significance Index: -0.1400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0163
    Cell Significance Index: -0.1500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0166
    Cell Significance Index: -0.2100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0206
    Cell Significance Index: -0.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0219
    Cell Significance Index: -0.4800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0268
    Cell Significance Index: -0.3500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0280
    Cell Significance Index: -0.3200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0280
    Cell Significance Index: -0.3300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0298
    Cell Significance Index: -0.3400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0306
    Cell Significance Index: -0.3600
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0332
    Cell Significance Index: -0.2300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0333
    Cell Significance Index: -0.3600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0336
    Cell Significance Index: -0.3600
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0342
    Cell Significance Index: -0.4500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0354
    Cell Significance Index: -0.4500
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0354
    Cell Significance Index: -0.3700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0396
    Cell Significance Index: -0.4500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0441
    Cell Significance Index: -0.6100
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: -0.0494
    Cell Significance Index: -0.4900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0513
    Cell Significance Index: -0.4800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0535
    Cell Significance Index: -0.6400
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -0.0581
    Cell Significance Index: -0.4400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0584
    Cell Significance Index: -0.6900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0622
    Cell Significance Index: -0.5900
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0631
    Cell Significance Index: -0.7000
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0746
    Cell Significance Index: -0.3600
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0834
    Cell Significance Index: -0.6900
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1002
    Cell Significance Index: -1.1600
  • Cell Name: serotonergic neuron (CL0000850)
    Fold Change: -0.1506
    Cell Significance Index: -0.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORD42A is a C/D box snoRNA, a subclass of small nucleolar RNAs that play a crucial role in the regulation of ribosome biogenesis and modification. snoRNAs are known to interact with various proteins, influencing the processing and function of ribosomal RNA (rRNA). SNORD42A, in particular, has been shown to be highly expressed in a range of cell types, including pericytes, cardiac endothelial cells, and immature innate lymphoid cells. This widespread expression suggests that SNORD42A may play a role in maintaining cellular homeostasis and regulating cellular differentiation. **Pathways and Functions:** The exact mechanisms by which SNORD42A regulates cellular processes are not yet fully understood. However, several pathways have been implicated in the function of SNORD42A: 1. **Ribosome biogenesis:** SNORD42A has been shown to interact with ribosomal proteins, influencing the processing and modification of rRNA. This interaction may regulate the assembly and function of ribosomes, which are essential for protein synthesis. 2. **Cell differentiation:** SNORD42A has been implicated in the regulation of cell differentiation in various cell types, including pericytes and cardiac endothelial cells. The expression of SNORD42A may influence the transition from a progenitor state to a differentiated state. 3. **Cell survival:** SNORD42A has been shown to regulate cell survival pathways, including the activation of anti-apoptotic proteins. This may contribute to the maintenance of cellular homeostasis and prevent cell death. **Clinical Significance:** While the clinical significance of SNORD42A is still unclear, its expression in various cell types suggests that it may play a role in several diseases. For example: 1. **Cardiovascular disease:** The expression of SNORD42A in cardiac endothelial cells and cardiac muscle myoblasts suggests that it may be involved in the development of cardiovascular disease. 2. **Immune system disorders:** The expression of SNORD42A in immature innate lymphoid cells and lymphoid lineage-restricted progenitor cells suggests that it may be involved in the regulation of the immune system. 3. **Neurological disorders:** The expression of SNORD42A in neuronal receptor cells and retinal rod cells suggests that it may be involved in the regulation of neurological function. In conclusion, SNORD42A is a small nucleolar RNA with widespread expression in various cell types. While its exact mechanisms of action are not yet fully understood, its involvement in ribosome biogenesis, cell differentiation, and cell survival pathways suggests that it may play a crucial role in maintaining cellular homeostasis. Further research is needed to elucidate the clinical significance of SNORD42A and its potential role in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.