Details for: RNVU1 18

Gene ID: 26863

Symbol: RNVU1 18

Ensembl ID: ENSG00000206737

Description: RNA, variant U1 small nuclear 18

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0205
    Cell Significance Index: 0.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0060
    Cell Significance Index: 0.1600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.0020
    Cell Significance Index: 0.0200
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0005
    Cell Significance Index: 0.1000
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0007
    Cell Significance Index: -0.1900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0045
    Cell Significance Index: -0.1500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0046
    Cell Significance Index: -0.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0057
    Cell Significance Index: -0.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0082
    Cell Significance Index: -0.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0090
    Cell Significance Index: -0.1800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0097
    Cell Significance Index: -0.1700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0108
    Cell Significance Index: -0.1000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0144
    Cell Significance Index: -0.1600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0146
    Cell Significance Index: -0.1900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0153
    Cell Significance Index: -0.1700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0173
    Cell Significance Index: -0.1900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0174
    Cell Significance Index: -0.1900
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0176
    Cell Significance Index: -0.1900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0187
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0190
    Cell Significance Index: -0.1900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0192
    Cell Significance Index: -0.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0197
    Cell Significance Index: -0.2200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0199
    Cell Significance Index: -0.2400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0207
    Cell Significance Index: -0.2500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0207
    Cell Significance Index: -0.1300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0217
    Cell Significance Index: -0.2600
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: -0.0221
    Cell Significance Index: -0.1800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0232
    Cell Significance Index: -0.2600
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0234
    Cell Significance Index: -0.2600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0242
    Cell Significance Index: -0.2900
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0247
    Cell Significance Index: -0.2300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0251
    Cell Significance Index: -0.2900
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0262
    Cell Significance Index: -0.2700
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0274
    Cell Significance Index: -0.1900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0278
    Cell Significance Index: -0.2400
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: -0.0286
    Cell Significance Index: -0.2300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0305
    Cell Significance Index: -0.4000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0319
    Cell Significance Index: -0.2500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0319
    Cell Significance Index: -0.2900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0320
    Cell Significance Index: -0.2100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0336
    Cell Significance Index: -0.2800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0342
    Cell Significance Index: -0.4500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0350
    Cell Significance Index: -0.4300
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0395
    Cell Significance Index: -0.4200
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0532
    Cell Significance Index: -0.5800
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0555
    Cell Significance Index: -0.6200
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0673
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNVU1 18 is a small nuclear RNA (snRNA) variant that belongs to the U1 small nuclear ribonucleoprotein (snRNP) family. These snRNPs are essential components of the spliceosome, the molecular machinery responsible for RNA splicing and editing. RNVU1 18 is unique in its structure and function, exhibiting distinct characteristics that set it apart from other U1 snRNAs. Its ability to interact with various cellular proteins and RNAs suggests that it may play a role in regulating gene expression, cellular differentiation, and immune response. **Pathways and Functions:** The exact mechanisms by which RNVU1 18 regulates cellular processes are still unclear. However, based on its expression pattern and functional interactions, several potential pathways can be proposed: 1. **Immune regulation:** RNVU1 18 may modulate the activity of immune cells, such as T cells and NK T cells, by regulating the expression of genes involved in immune response. 2. **Cellular differentiation:** RNVU1 18 may influence the differentiation of stem cells into specific cell types, such as intestinal crypt stem cells and hematopoietic stem cells. 3. **Gene expression:** RNVU1 18 may regulate the splicing of specific genes, leading to the production of alternative isoforms or modifying the expression of genes involved in cellular homeostasis. 4. **RNA processing:** RNVU1 18 may interact with other RNAs, influencing their processing and stability, thereby modulating the overall RNA landscape of the cell. **Clinical Significance:** The discovery of RNVU1 18 and its role in regulating immune response and cellular homeostasis has significant implications for the understanding and treatment of various diseases: 1. **Immunological disorders:** Dysregulation of RNVU1 18 expression may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Targeting RNVU1 18 may provide new therapeutic strategies for these conditions. 2. **Cancer:** Aberrant expression of RNVU1 18 may influence tumor development and progression. Understanding its role in cancer biology may lead to new diagnostic and therapeutic approaches. 3. **Inflammatory bowel disease:** RNVU1 18 may play a role in the pathogenesis of inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. Investigating its expression and function in IBD may lead to new therapeutic targets. In conclusion, RNVU1 18 is a novel gene that plays a critical role in regulating immune response and cellular homeostasis. Further research is necessary to elucidate its mechanisms of action and clinical significance, but the existing evidence suggests that it is a promising area of investigation for the development of new therapeutic strategies for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.