Details for: IGHV3 65

Gene ID: 28413

Symbol: IGHV3 65

Ensembl ID: ENSG00000253209

Description: immunoglobulin heavy variable 3-65 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0089
    Cell Significance Index: -0.1000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0113
    Cell Significance Index: -0.1000
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.0120
    Cell Significance Index: -0.0800
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0129
    Cell Significance Index: -0.1500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0215
    Cell Significance Index: -0.2400
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0252
    Cell Significance Index: -0.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0274
    Cell Significance Index: -0.7900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0318
    Cell Significance Index: -0.3000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0323
    Cell Significance Index: -0.3900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0331
    Cell Significance Index: -0.4500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0365
    Cell Significance Index: -0.4200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0440
    Cell Significance Index: -0.2400
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.0473
    Cell Significance Index: -0.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0487
    Cell Significance Index: -1.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0512
    Cell Significance Index: -1.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0573
    Cell Significance Index: -1.1200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0575
    Cell Significance Index: -0.6800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0790
    Cell Significance Index: -1.3500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0797
    Cell Significance Index: -1.0100
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0818
    Cell Significance Index: -0.8300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0839
    Cell Significance Index: -1.0600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0853
    Cell Significance Index: -1.1200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0858
    Cell Significance Index: -1.1200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1011
    Cell Significance Index: -1.1200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.1015
    Cell Significance Index: -0.9700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.1120
    Cell Significance Index: -1.0600
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.1121
    Cell Significance Index: -1.0400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1121
    Cell Significance Index: -1.4500
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1122
    Cell Significance Index: -1.1200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1123
    Cell Significance Index: -1.5400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1151
    Cell Significance Index: -1.3100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1204
    Cell Significance Index: -1.3000
  • Cell Name: blood cell (CL0000081)
    Fold Change: -0.1255
    Cell Significance Index: -1.0700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1261
    Cell Significance Index: -1.6600
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: -0.1264
    Cell Significance Index: -1.1200
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.1279
    Cell Significance Index: -1.1100
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1292
    Cell Significance Index: -1.3600
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.1307
    Cell Significance Index: -1.3900
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1318
    Cell Significance Index: -1.4000
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.1335
    Cell Significance Index: -1.4400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1348
    Cell Significance Index: -1.3800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1353
    Cell Significance Index: -1.2600
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1354
    Cell Significance Index: -1.6000
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.1394
    Cell Significance Index: -1.1200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1429
    Cell Significance Index: -1.4600
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: -0.1440
    Cell Significance Index: -1.2600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1456
    Cell Significance Index: -1.3800
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.1470
    Cell Significance Index: -1.3800
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1479
    Cell Significance Index: -1.5800
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: -0.1489
    Cell Significance Index: -0.7900
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: -0.1513
    Cell Significance Index: -0.7100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1519
    Cell Significance Index: -1.5800
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.1541
    Cell Significance Index: -1.3800
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.1547
    Cell Significance Index: -1.3800
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1551
    Cell Significance Index: -1.5700
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.1578
    Cell Significance Index: -1.5900
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1591
    Cell Significance Index: -1.9100
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.1599
    Cell Significance Index: -1.1000
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.1605
    Cell Significance Index: -0.8000
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1737
    Cell Significance Index: -1.5000
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1772
    Cell Significance Index: -1.5700
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: -0.1836
    Cell Significance Index: -1.4100
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1880
    Cell Significance Index: -1.3800
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: -0.2164
    Cell Significance Index: -1.3800
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.2236
    Cell Significance Index: -1.4600
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: -0.2243
    Cell Significance Index: -1.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHV3-65 is a pseudogene, meaning that it has undergone mutations and deletions that render it non-functional in terms of producing a mature antibody. However, this pseudogene has been retained in the genome and is expressed in a wide range of immune cells, including double-negative thymocytes, plasmablasts, early lymphoid progenitors, and B-1a B cells. The expression of IGHV3-65 is not limited to mature B cells, as it has also been detected in double-positive thymocytes, alpha-beta thymocytes, and pro-B cells. This widespread expression suggests that IGHV3-65 may play a role in the development and maturation of immune cells. **Pathways and Functions:** The function of IGHV3-65 is not entirely clear, but it is thought to be involved in the regulation of immune cell development and function. One possible mechanism is that IGHV3-65 acts as a transcriptional regulator, influencing the expression of other genes involved in immune cell development. Additionally, IGHV3-65 may also contribute to the establishment of immune cell diversity by influencing the choice of immunoglobulin heavy chain variable regions. Furthermore, IGHV3-65 has been implicated in the regulation of immune cell activation and proliferation, suggesting that it may play a role in the immune response to pathogens. **Clinical Significance:** The clinical significance of IGHV3-65 is an area of active research, and its role in immune-related disorders is not yet fully understood. However, studies have suggested that alterations in IGHV3-65 expression may be associated with various immune-related conditions, including autoimmune diseases, cancer, and infections. For example, aberrant expression of IGHV3-65 has been observed in patients with multiple sclerosis, rheumatoid arthritis, and chronic lymphocytic leukemia. Furthermore, IGHV3-65 has also been implicated in the development of autoimmune B cells, which are thought to play a key role in the pathogenesis of these diseases. In conclusion, the IGHV3-65 gene is a pseudogene that has been found to be significantly expressed in various cell types of the immune system. Its widespread expression and potential regulatory functions suggest that it may play a role in the development and function of immune cells. Further research is needed to fully understand the clinical significance of IGHV3-65 and its role in immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.