Details for: TRAJ48

Gene ID: 28707

Symbol: TRAJ48

Ensembl ID: ENSG00000211841

Description: T cell receptor alpha joining 48

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.4746
    Cell Significance Index: 6.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0239
    Cell Significance Index: 0.5200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0195
    Cell Significance Index: 0.2200
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.0126
    Cell Significance Index: 0.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.0024
    Cell Significance Index: 0.0500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0016
    Cell Significance Index: -0.0300
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0059
    Cell Significance Index: -0.0700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0081
    Cell Significance Index: -0.1100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0083
    Cell Significance Index: -0.1700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0107
    Cell Significance Index: -0.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0122
    Cell Significance Index: -0.1500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0122
    Cell Significance Index: -0.1000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0126
    Cell Significance Index: -0.1700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0134
    Cell Significance Index: -0.1600
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0150
    Cell Significance Index: -0.1600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0164
    Cell Significance Index: -0.1600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0167
    Cell Significance Index: -0.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0173
    Cell Significance Index: -0.3200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0175
    Cell Significance Index: -0.2200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0176
    Cell Significance Index: -0.2200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0185
    Cell Significance Index: -0.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0209
    Cell Significance Index: -0.2000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0213
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0214
    Cell Significance Index: -0.2000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0220
    Cell Significance Index: -0.2600
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0224
    Cell Significance Index: -0.2800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0228
    Cell Significance Index: -0.2100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0230
    Cell Significance Index: -0.2900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0237
    Cell Significance Index: -0.2700
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0262
    Cell Significance Index: -0.2900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0263
    Cell Significance Index: -0.2500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0274
    Cell Significance Index: -0.2600
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0289
    Cell Significance Index: -0.3400
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0310
    Cell Significance Index: -0.3300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0314
    Cell Significance Index: -0.2400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0325
    Cell Significance Index: -0.3300
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0328
    Cell Significance Index: -0.3300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0330
    Cell Significance Index: -0.2700
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0337
    Cell Significance Index: -0.3400
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0371
    Cell Significance Index: -0.3200
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0377
    Cell Significance Index: -0.3300
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: -0.0378
    Cell Significance Index: -0.3100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0379
    Cell Significance Index: -0.3200
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0379
    Cell Significance Index: -0.2000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0407
    Cell Significance Index: -0.4100
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0420
    Cell Significance Index: -0.3400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0422
    Cell Significance Index: -0.2300
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0424
    Cell Significance Index: -0.3300
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: -0.0444
    Cell Significance Index: -0.3300
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.0458
    Cell Significance Index: -0.3200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.0543
    Cell Significance Index: -0.4300
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: -0.1116
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRAJ48 is a gene with a relatively short coding sequence, which is expressed in multiple cell types, including alpha-beta T cells, B cells, and natural killer T cells. It is also expressed in retinal rod cells, suggesting a potential role in non-immune tissues. The gene is highly conserved across species, indicating its essential function in immune cell development and function. Notably, TRAJ48 is co-expressed with other TCR components, suggesting its involvement in TCR assembly and function. **Pathways and Functions:** The TCR complex, including TRAJ48, plays a central role in recognizing and responding to antigens. The TCR is composed of two chains: alpha (α) and beta (β), which are joined by a disulfide bond. TRAJ48, along with other TCR components, is involved in the assembly and function of the TCR complex. The TCR complex interacts with major histocompatibility complex (MHC) molecules on antigen-presenting cells, allowing for the recognition of specific antigens. This interaction triggers a signaling cascade that ultimately leads to T cell activation, proliferation, and differentiation. TRAJ48 may play a role in modulating this signaling cascade, influencing T cell function and immune responses. **Clinical Significance:** Dysregulation of the TCR complex, including TRAJ48, has been implicated in various autoimmune and immunodeficiency disorders. For example, alterations in the TCR complex have been associated with multiple sclerosis, rheumatoid arthritis, and type 1 diabetes. Additionally, mutations in TRAJ48 have been linked to autoimmune diseases, such as lupus and rheumatoid arthritis. Furthermore, TRAJ48 may play a role in cancer immunity, as alterations in the TCR complex have been observed in various types of cancer. Understanding the specific role of TRAJ48 in immune regulation and its clinical significance may provide valuable insights into the development of novel therapeutic strategies for immune-related disorders. In conclusion, TRAJ48 is a gene with a complex and multifaceted role in immune cell function and disease. Further research is needed to elucidate the specific mechanisms by which TRAJ48 influences T cell function and immune responses. The clinical significance of TRAJ48 highlights the importance of understanding the molecular mechanisms underlying immune regulation and the development of novel therapeutic strategies for immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.